In:
Journal of Ophthalmology, Hindawi Limited, Vol. 2019 ( 2019-06-12), p. 1-10
Abstract:
Posterior capsule opacification (PCO) is a common complication after cataract surgery attributed to the proliferation and migration of postoperative residual lens epithelial cells (LECs). The long noncoding RNA (lncRNA) FEZ family zinc finger 1 antisense RNA 1 (FEZF1-AS1) promotes the proliferation and migration of multiple types of cancer cells. Here, we discovered that FEZF1-AS1 is markedly upregulated in TGF- β 2-treated SRA01/04 cells. In addition, the proliferation and migration of SRA01/04 cells were enhanced following TGF- β 2 treatment. FEZF1-AS1 knockdown inhibited the TGF- β 2-induced proliferation and migration of SRA01/04 cells. Accordingly, FEZF1-AS1 overexpression promoted the TGF- β 2-induced proliferation and migration of SRA01/04 cells. Finally, FEZF1-AS1 upregulated TGF- β 2-induced SRA01/04 cell proliferation and migration via boosting FEZF1 protein levels. Our findings indicate that the dysregulation of FEZF1-AS1 participates in the TGF- β 2-induced proliferation and migration of human lens epithelial cells (HLECs), which might be achieved, at least in part, through the induction of FEZF1 expression.
Type of Medium:
Online Resource
ISSN:
2090-004X
,
2090-0058
DOI:
10.1155/2019/4736203
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2019
detail.hit.zdb_id:
2546525-9
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