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  • 1
    Online Resource
    Online Resource
    Experimental Study on Flow Characteristics of Aeolian Sand in Fractures
    Hindawi Limited ; 2021
    In:  Advances in Civil Engineering Vol. 2021 ( 2021-2-14), p. 1-12
    Details
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2021 ( 2021-2-14), p. 1-12
    Abstract: It is one of the important safety problems in the process of mining shallow coal seams in western China that the rock mass affected by mining stress breaks and forms a penetrating fracture, leading to a sand burst in the working face. The self-developed test system is used to carry out the experimental study on the flow characteristics of Aeolian sand in fractures. The research work is focused on the influence of several parameters, such as the thickness of the Aeolian sand layer, the fracture opening, and the fracture dip angle on the velocity of sand particles in fractures. The results show the following: (1) The influence of fracture opening and fracture angle on sand burst rate is much greater than that of sand thickness. No matter what the fracture angle and fracture opening value are, the influence weight of sand thickness on sand burst rate is almost zero. (2) When other conditions are unchanged, with the increase of fracture dip angle, the sand burst rate increases significantly, and the relationship between the sand burst rate and the fracture dip angle is exponential. (3) The influence weight of fracture opening is the largest. With the increase of fracture opening, the sand burst rate increases logarithmically. Finally, according to the test results, the relation equation which can simultaneously describe the influence of fracture opening and fracture inclination on the rate of the sand burst is fitted. This study can provide a theoretical basis and scientific guidance for the prevention and control of coal mine sand inrush disasters caused by roof cracking in western coal mines.
    Type of Medium: Online Resource
    ISSN: 1687-8094 , 1687-8086
    URL: Article
    DOI: 10.1155/2021/6665589
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2449760-5
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  • 2
    Online Resource
    Online Resource
    Mineral and bone disorder in Chinese dialysis patients: a multicenter study
    Springer Science and Business Media LLC ; 2012
    In:  BMC Nephrology Vol. 13, No. 1 ( 2012-12)
    Details
    In: BMC Nephrology, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2012-12)
    Abstract: Mineral and bone disorder (MBD) in patients with chronic kidney disease is associated with increased morbidity and mortality. Studies regarding the status of MBD treatment in developing countries, especially in Chinese dialysis patients are extremely limited. Methods A cross-sectional study of 1711 haemodialysis (HD) patients and 363 peritoneal dialysis (PD) patients were enrolled. Parameters related to MBD, including serum phosphorus (P), calcium (Ca), intact parathyroid hormone (iPTH) were analyzed. The achievement of MBD targets was compared with the results from the Dialysis Outcomes and Practice Study (DOPPS) 3 and DOPPS 4. Factors associated with hyperphosphatemia were examined. Results Total 2074 dialysis patients from 28 hospitals were involved in this study. Only 38.5%, 39.6% and 26.6% of them met the Kidney Disease Outcomes Quality Initiative (K/DOQI) defined targets for serum P, Ca and iPTH levels. Serum P and Ca levels were statistically higher (P  〈  0.05) in the HD patients compared with those of PD patients, which was (6.3 ± 2.1) mg/dL vs (5.7 ± 2.0) mg/dL and (9.3 ± 1.1) mg/dL vs (9.2 ± 1.1) mg/dL, respectively. Serum iPTH level were statistically higher in the PD patients compared with those of HD patients (P = 0.03). The percentage of patients reached the K/DOQI targets for P (37.6% vs 49.8% vs 54.5%, P  〈  0.01), Ca (38.6% vs 50.4% vs 56.0%, P  〈  0.01) and iPTH (26.5% vs 31.4% vs 32.1%, P  〈  0.01) were lower among HD patients, compared with the data from DOPPS 3 and DOPPS 4. The percentage of patients with serum phosphorus level above 5.5 mg/dL was 57.4% in HD patients and 47.4% in PD patients. Age, dialysis patterns and region of residency were independently associated with hyperphosphatemia. Conclusions Status of MBD is sub-optimal among Chinese patients receiving dialysis. The issue of hyperphosphatemia is prominent and needs further attention.
    Type of Medium: Online Resource
    ISSN: 1471-2369
    URL: Article
    DOI: 10.1186/1471-2369-13-116
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2012
    detail.hit.zdb_id: 2041348-8
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  • 3
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    Online Resource
    Classification for Transient Overvoltages in Offshore Wind Farms Based on Sparse Decomposition
    Institute of Electrical and Electronics Engineers (IEEE) ; 2022
    In:  IEEE Transactions on Power Delivery Vol. 37, No. 3 ( 2022-6), p. 1974-1985
    Details
    In: IEEE Transactions on Power Delivery, Institute of Electrical and Electronics Engineers (IEEE), Vol. 37, No. 3 ( 2022-6), p. 1974-1985
    Type of Medium: Online Resource
    ISSN: 0885-8977 , 1937-4208
    URL: Article
    DOI: 10.1109/TPWRD.2021.3102147
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2022
    detail.hit.zdb_id: 2027539-0
    detail.hit.zdb_id: 165807-4
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  • 4
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    Comparison of complete and minimal mediastinal lymph node dissection for non‐small cell lung cancer: Results of a prospective randomized trial
    Wiley ; 2013
    In:  Thoracic Cancer Vol. 4, No. 4 ( 2013-11), p. 416-421
    Details
    In: Thoracic Cancer, Wiley, Vol. 4, No. 4 ( 2013-11), p. 416-421
    Abstract: To compare surgical results, pathological staging, and survival between complete and minimal mediastinal lymph node dissection for non‐small cell lung cancer ( NSCLC ). Methods A randomized controlled trial was carried out in 202 patients who were assigned to undergo either skeletonized complete mediastinal lymph node dissection ( CLD ) or minimal mediastinal lymph node dissection ( MLD ). Clinical and pathological characteristics, surgical results, postoperative staging, and five‐year survival were recorded for statistical analysis. Results Significantly more stations of lymph nodes were harvested through CLD, than MLD (8.9 vs. 6.2, P 〈 0.001). There was no difference in major complications ( CLD 14.7% vs. MLD 14.0%, P = 0.884) or postoperative death ( CLD 2.1% vs. MLD 1.9%, P = 0.904). No significant difference was detected in pathological staging between the two groups. The p N 2 rates (27.1% vs. 24.2%), skip‐mediastinal metastasis (9.3% vs. 7.4%), and multi‐stational mediastinal involvement (15.0% vs. 16.8%) were similar between MLD and CLD . However, CLD had significantly better five‐year survival than MLD (55.7% vs. 37.7%, P = 0.005), especially in patients with a tumor size 〉 3 cm, pleural invasion, pN1‐N2 , stage II ‐ III , adenocarcinoma, and low‐differentiation carcinoma. Upon multivariate analysis, CLD, along with stage I and high‐differentiation, were independent prognostic factors for better overall survival. Conclusions Complete and minimal mediastinal dissections have similar surgical risks and mediastinal staging effect in patients with NSCLC . Minimal dissection is enough for early stage high‐differentiation tumors. For patients with stage II‐III or low‐differentiation carcinoma, skeletonized complete mediastinal dissection may improve survival compared with minimal dissection.
    Type of Medium: Online Resource
    ISSN: 1759-7706 , 1759-7714
    URL: Issue
    URL: Article
    DOI: 10.1111/tca.2013.4.issue-4
    DOI: 10.1111/1759-7714.12040
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2559245-2
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  • 5
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    Online Resource
    Comparison of perioperative outcomes between open and minimally invasive esophagectomy for esophageal cancer
    Wiley ; 2015
    In:  Thoracic Cancer Vol. 6, No. 3 ( 2015-05), p. 303-306
    Details
    In: Thoracic Cancer, Wiley, Vol. 6, No. 3 ( 2015-05), p. 303-306
    Abstract: To compare surgical outcomes of thoracoscopic and laparoscopic esophagectomy with open esophagectomy in order to study the learning curve of minimally invasive surgery for esophageal cancers. Methods Among 109 esophageal cancer patients retrospectively studied, 59 patients underwent minimally invasive esophagectomy ( MIE ) and 50 underwent open surgery ( OE ). In the MIE group, the first 30 patients received hybrid procedures, including 16 thoracoscopic esophagectomies and 14 laparoscopic maneuvers. The later 29 patients received thoraco‐laparoscopic esophagectomy ( TLE ). Results The overall morbidity of MIE and OE was 42.4% (25/59) and 44.0% (22/50), respectively, with no statistical difference. However, the MIE group had a significantly lower incidence of functional complication (1.79%, 1/59) than the OE group (32.0%, 16/50, P 〈 0.01). The technical complication rate was not significantly different between the two groups (14/59, 23.7% vs. 6/50, 12.0%, P = NS ), nor was the overall complication rate between the 30 early period cases and the 29 later cases ( P = NS ); although the later cases had TLE and there was no recurrent laryngeal nerve injury. Conclusion Minimally invasive approaches may help to decrease the risk of functional complication but not technical problems, after esophagectomy. For esophageal cancer patients to benefit from this minimally invasive surgery, an extended learning curve is necessary to avoid technical problems, such as anastomotic leakage and recurrent laryngeal nerve palsy.
    Type of Medium: Online Resource
    ISSN: 1759-7706 , 1759-7714
    URL: Issue
    URL: Article
    DOI: 10.1111/tca.2015.6.issue-3
    DOI: 10.1111/1759-7714.12184
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2559245-2
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  • 6
    Online Resource
    Online Resource
    Research on Failure Characteristics and Zoning Control Technology of Thick-Soft Surrounding Rock for Deep Gob-Side Entry Retaining
    Hindawi Limited ; 2020
    In:  Shock and Vibration Vol. 2020 ( 2020-11-23), p. 1-14
    Details
    In: Shock and Vibration, Hindawi Limited, Vol. 2020 ( 2020-11-23), p. 1-14
    Abstract: Controlling the large deformation caused by bed separation failure of thick and soft surrounding rock in gob-side entry retaining is difficult. The deformation and failure modes of thick and soft surrounding rock are summarized and classified based on field research, theoretical analysis, laboratory tests, and actual measurements. Systematic research is conducted on the lithologic characteristics, failure characteristics, and control methods of the surrounding rock. The research findings are as follows: (1) The low strength, softening, and water swelling of thick mudstone, as well as its cataclasis, dilatancy, and long-term creep under strong mining and high stress are the objective reasons for large deformation of the surrounding rock. (2) Due to the weak stability of the surrounding rock-support structure and low collaborative roof side bearing capacity, no complete supporting structure is formed with the supporting system, causing the support body in each area to be crushed one by one, which is the subjective reason for the deformation and failure of the surrounding rock. (3) The deformation and failure characteristics of thick and soft surrounding rock in gob-side entry retaining are primarily divided into eight types: roof bending and sinking type, roof cutting along filling body, rib spalling type, roof fall type, filling body rotation type, filling body crushing type, roof step type, and roof cutting along the coal side. The initial points and key points for a chain reaction of each failure type are determined. (4) The surrounding rock is divided into 10 support zones at four levels, and control technology for “zonal support and overall reinforcement” is put forward. The mechanical effect of the support body in each zone and its role in maintaining the stability of surrounding rock are analyzed. This technology can ensure the integrity of the surrounding rock structure and improve the roof side collaborative bearing capacity.
    Type of Medium: Online Resource
    ISSN: 1875-9203 , 1070-9622
    URL: Article
    DOI: 10.1155/2020/6613514
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2070162-7
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  • 7
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    Online Resource
    Emerging mechanisms progress of colorectal cancer liver metastasis
    Frontiers Media SA ; 2022
    In:  Frontiers in Endocrinology Vol. 13 ( 2022-12-8)
    Details
    In: Frontiers in Endocrinology, Frontiers Media SA, Vol. 13 ( 2022-12-8)
    Abstract: Colorectal cancer (CRC) is the third most common malignancy and the second most common cause of cancer-related mortality worldwide. A total of 20% of CRC patients present with distant metastasis. The hepatic portal venous system, responsible for collecting most intestinal blood, makes the liver the most common site of CRC metastasis. The formation of liver metastases from colorectal cancer is a long and complex process. It involves the maintenance of primary tumors, vasculature invasion, distant colonization, and metastasis formation. In this review, we serve on how the CRC cells acquire stemness, invade the vascular, and colonize the liver. In addition, we highlight how the resident cells of the liver and immune cells interact with CRC cells. We also discuss the current immunotherapy approaches and challenges we face, and finally, we look forward to finding new therapeutic targets based on novel sequencing technologies.
    Type of Medium: Online Resource
    ISSN: 1664-2392
    URL: Article
    DOI: 10.3389/fendo.2022.1081585
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2592084-4
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  • 8
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    Online Resource
    Propagation of hydrogen–oxygen flames in Hele-Shaw cells
    Elsevier BV ; 2021
    In:  International Journal of Hydrogen Energy Vol. 46, No. 21 ( 2021-03), p. 12009-12015
    Details
    In: International Journal of Hydrogen Energy, Elsevier BV, Vol. 46, No. 21 ( 2021-03), p. 12009-12015
    Type of Medium: Online Resource
    ISSN: 0360-3199
    URL: Article
    DOI: 10.1016/j.ijhydene.2021.01.071
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 1484487-4
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  • 9
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    Online Resource
    Orosomucoid 1 promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing macrophage M2 polarization
    Springer Science and Business Media LLC ; 2023
    In:  Scientific Reports Vol. 13, No. 1 ( 2023-08-28)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-08-28)
    Abstract: Approximately 25–30% of those affected by colorectal cancer (CRC), the most prevalent gastrointestinal malignancy, develop metastases. The survival rate of patients with liver metastasis of CRC (CRLM) remains low owing to its unpredictability and a lack of biomarkers that can be applied to distinguish groups at higher risk for CRLM among patients with CRC. Therefore, our study aimed to find biomarkers that can predict the risk of CRLM. Screening of the Gene Expression Omnibus database, supported by an analysis of clinically obtained tissue and serum data using qPCR and ELISA, in an attempt to identify relevant biomarkers, enabled us to determine that orosomucoid 1 (ORM1) was differentially expressed in liver metastases and primary tumors of patients with CRC. Functionally, overexpression of ORM1 promoted the epithelial-mesenchymal transition and the proliferative, migratory, and invasive activities of MC38 cells and activated the PI3K/AKT signaling pathway. Moreover, MC38 cells overexpressing ORM1 enhanced the tumor immune microenvironment by promoting macrophage M2 polarization and elevating interleukin-10 (IL-10) expression. In vivo experiments further confirmed in vitro results, indicating that liver metastases elevated by ORM1 were partially attenuated by the depletion of macrophages or IL-10. Considered together, ORM1 promotes CRC progression and liver metastasis by regulating tumor cell growth and inducing macrophage M2 polarization, which mediates tumor immune tolerance, and thus acts as a potential predictive marker and therapeutic target in CRLM.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-023-40404-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2615211-3
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  • 10
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    Online Resource
    M2 tumor-associated macrophage mediates the maintenance of stemness to promote cisplatin resistance by secreting TGF-β1 in esophageal squamous cell carcinoma
    Springer Science and Business Media LLC ; 2023
    In:  Journal of Translational Medicine Vol. 21, No. 1 ( 2023-01-14)
    Details
    In: Journal of Translational Medicine, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2023-01-14)
    Abstract: Esophageal squamous cell carcinoma (ESCC) is a deadly gastrointestinal malignancy, and chemotherapy resistance is a key factor leading to its poor prognosis. M2 tumor-associated macrophages (M2-TAMs) may be an important cause of chemoresistance in ESCC, but its exact mechanism is still unclear. Methods In order to study the role of M2-TAMs in ESCC chemoresistance, CCK-8, clone formation assay, flow cytometric apoptosis assay, qRT-PCR, western blotting, and serum-free sphere formation assays were used. In vivo animal experiments and human ESCC tissues were used to confirm the findings. Results In vitro and in vivo animal experiments, M2-TAMs reduced the sensitivity of ESCC cells to cisplatin. Mechanistically, M2-TAMs highly secreted TGF-β1 which activated the TGFβR1-smad2/3 pathway to promote and maintain the stemness characteristic of ESCC cells, which could inhibit the sensitivity to cisplatin. Using TGFβ signaling inhibitor SB431542 or knockdown of TGFβR1 could reverse the cisplatin resistance of ESCC cells. In 92 cases of human ESCC tissues, individuals with a high density of M2-TAMs had considerably higher levels of TGF-β1. These patients also had worse prognoses and richer stemness markers. Conclusion TGF-β1 secreted from M2-TAMs promoted and maintained the stemness characteristic to induce cisplatin resistance in ESCC by activating the TGFβ1-Smad2/3 pathway.
    Type of Medium: Online Resource
    ISSN: 1479-5876
    URL: Article
    DOI: 10.1186/s12967-022-03863-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2118570-0
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