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  • 1
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    Online Resource
    Influence of Periprostatic Fat on Prostate Volume and Prostate-Specific Antigen
    Elsevier BV ; 2013
    In:  Brachytherapy Vol. 12 ( 2013-3), p. S71-
    Details
    In: Brachytherapy, Elsevier BV, Vol. 12 ( 2013-3), p. S71-
    Type of Medium: Online Resource
    ISSN: 1538-4721
    URL: Article
    DOI: 10.1016/j.brachy.2013.01.145
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2013
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  • 2
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    Chronic rhinosinusitis in eosinophilic granulomatosis with polyangiitis: clinical presentation and antineutrophil cytoplasmic antibodies
    Wiley ; 2020
    In:  International Forum of Allergy & Rhinology Vol. 10, No. 2 ( 2020-02), p. 217-222
    Details
    In: International Forum of Allergy & Rhinology, Wiley, Vol. 10, No. 2 ( 2020-02), p. 217-222
    Abstract: In this study we aim to describe presenting characteristics and identify prognostic factors for disease resolution in patients with chronic rhinosinusitis (CRS) in the setting of eosinophilic granulomatosis with polyangiitis (EGPA). Methods Patients evaluated at a tertiary care center with diagnoses of EGPA and CRS were identified. Descriptive statistics were obtained. Univariate analysis was used to search for prognostic factors associated with higher Lund‐Mackay score at presentation and disease resolution. Results Forty‐four patients were included with a mean age of 52.7 (standard deviation, 14) years. Twenty‐one patients (47.7%) were female, all had a diagnosis of asthma, and 36 (83.7%) had eosinophils 〉 10%. Common presenting symptoms for CRS included nasal discharge (87.9%) followed by nasal congestion (83.9%) and facial pain and pressure (83.8%). Medical management of CRS included systemic corticosteroids (93.2%) and systemic antibiotics (75%). Surgical intervention occurred in 29 patients (67%). Nine patients (20.5%) had resolution of sinus symptoms, including 4 with imaging confirmation. Fourteen patients (31.8%) had continued CRS, but with improved symptoms, whereas 9 patients (20.5%) had continued CRS with no improvement in symptoms. Eleven patients (25%) were lost to follow‐up and 4 (9.1%) died. Univariate analysis did not show antineutrophil cytoplasmic antibody positivity, presence of peripheral eosinophilia, gender, age, or absence of systemic therapy to be predictive of higher Lund‐Mackay score at presentation or predictive of disease resolution. Conclusion CRS in patients with EGPA is often refractory to medical and surgical management. Treatment of these patients should occur in a multidisciplinary setting.
    Type of Medium: Online Resource
    ISSN: 2042-6976 , 2042-6984
    URL: Issue
    URL: Article
    DOI: 10.1002/alr.v10.2
    DOI: 10.1002/alr.22503
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2604059-1
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  • 3
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    Unusually high prostate-specific antigen bounce after prostate brachytherapy: Searching for etiologic factors
    Elsevier BV ; 2013
    In:  Brachytherapy Vol. 12, No. 6 ( 2013-11), p. 603-607
    Details
    In: Brachytherapy, Elsevier BV, Vol. 12, No. 6 ( 2013-11), p. 603-607
    Type of Medium: Online Resource
    ISSN: 1538-4721
    URL: Article
    DOI: 10.1016/j.brachy.2013.05.005
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2013
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  • 4
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    A personalized platform identifies trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer
    American Association for the Advancement of Science (AAAS) ; 2019
    In:  Science Advances Vol. 5, No. 5 ( 2019-05-03)
    Details
    In: Science Advances, American Association for the Advancement of Science (AAAS), Vol. 5, No. 5 ( 2019-05-03)
    Abstract: Colorectal cancer remains a leading source of cancer mortality worldwide. Initial response is often followed by emergent resistance that is poorly responsive to targeted therapies, reflecting currently undruggable cancer drivers such as KRAS and overall genomic complexity. Here, we report a novel approach to developing a personalized therapy for a patient with treatment-resistant metastatic KRAS-mutant colorectal cancer. An extensive genomic analysis of the tumor’s genomic landscape identified nine key drivers. A transgenic model that altered orthologs of these nine genes in the Drosophila hindgut was developed; a robotics-based screen using this platform identified trametinib plus zoledronate as a candidate treatment combination. Treating the patient led to a significant response: Target and nontarget lesions displayed a strong partial response and remained stable for 11 months. By addressing a disease’s genomic complexity, this personalized approach may provide an alternative treatment option for recalcitrant disease such as KRAS-mutant colorectal cancer.
    Type of Medium: Online Resource
    ISSN: 2375-2548
    URL: Article
    DOI: 10.1126/sciadv.aav6528
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2019
    detail.hit.zdb_id: 2810933-8
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  • 5
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    Dermal Fat Grafting to Reconstruct the Parotidectomy Defect Normalizes Facial Attention
    Wiley ; 2021
    In:  The Laryngoscope Vol. 131, No. 1 ( 2021-01)
    Details
    In: The Laryngoscope, Wiley, Vol. 131, No. 1 ( 2021-01)
    Abstract: Use validated eye‐tracking technology to objectively measure 1) the attentional distraction of facial contour defects after superficial and total parotidectomy and 2) changes in attentional distraction with abdominal dermal fat graft reconstruction. Methods Standardized frontal and oblique facial images of 16 patients who had undergone superficial or total parotidectomy with or without fat graft reconstruction; four normal controls were obtained. One hundred casual observers were recruited to view these images, and gaze data were collected using a Tobii Pro eye‐tracking system. Gaze durations for predefined facial areas of interest were analyzed using mixed‐effects linear regression to test study hypotheses. Results For frontal images, total parotidectomy increased gaze to the operated parotid area compared to the contralateral nonoperated parotid area (92 milliseconds, 95% confidence interval [CI]: 48‐138 milliseconds, P   〈  .001). Fat grafting normalized the attentional distraction, with no difference in gaze time on the operated parotid region compared to normal control faces ( P = .414). For oblique images, total parotidectomy increased gaze to the operated parotid area compared to the contralateral nonoperated parotid area (658 milliseconds, 95% CI: 463‐854 milliseconds, P   〈  .001). Fat grafting normalized this attentional distraction, with no difference in gaze time on the operated parotid region compared to normal control faces ( P = .504). In both views, superficial parotidectomy demonstrated no significant attentional distractions, with or without fat grafting. Conclusions This eye‐tracking study objectively demonstrates that total parotidectomy results in a facial contour deformity that is distracting to observers, whereas superficial parotidectomy does not. For total parotidectomy, this attentional distraction can be normalized with dermal fat graft reconstruction. Level of Evidence 3b Laryngoscope , 131:E124–E131, 2021
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    URL: Article
    DOI: 10.1002/lary.v131.1
    DOI: 10.1002/lary.28890
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2026089-1
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  • 6
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    Prostate-Specific Antigen Bounce Mimicking PSA Failure after Prostate Brachytherapy: Searching for Etiological Factors
    Elsevier BV ; 2013
    In:  Brachytherapy Vol. 12 ( 2013-3), p. S71-
    Details
    In: Brachytherapy, Elsevier BV, Vol. 12 ( 2013-3), p. S71-
    Type of Medium: Online Resource
    ISSN: 1538-4721
    URL: Article
    DOI: 10.1016/j.brachy.2013.01.146
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2013
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  • 7
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    Influence of Body Mass Index and Periprostatic Fat on Rectal Dosimetry in Permanent Seed Prostate Brachytherhapy
    Elsevier BV ; 2014
    In:  Brachytherapy Vol. 13 ( 2014-03), p. S67-
    Details
    In: Brachytherapy, Elsevier BV, Vol. 13 ( 2014-03), p. S67-
    Type of Medium: Online Resource
    ISSN: 1538-4721
    URL: Article
    DOI: 10.1016/j.brachy.2014.02.315
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2014
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  • 8
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    Analysis of Abdominal Dermal‐Fat Grafting to Repair Parotidectomy Defects: An 18‐Year Cohort Study
    Wiley ; 2020
    In:  The Laryngoscope Vol. 130, No. 9 ( 2020-09), p. 2144-2147
    Details
    In: The Laryngoscope, Wiley, Vol. 130, No. 9 ( 2020-09), p. 2144-2147
    Abstract: To assess the outcomes of abdominal dermal‐fat grafting following superficial and total parotidectomy. Methods A retrospective chart review of parotidectomy patients was performed. Patients were divided into four groups based on surgical extent and grafting status: superficial parotidectomy (SP), superficial parotidectomy with grafting (SPg), total parotidectomy (TP), and total parotidectomy with grafting (TPg). Complication rates and operative times were then compared between surgically matched groups (SP vs. SPg, TP vs. TPg). Complications included graft necrosis, gustatory sweating, first‐bite syndrome, infection, hematoma, sialocele, and seroma. Data was analyzed via chi‐square and two‐sample t testing, logistic regression, and one‐way analysis of variance. Results The cohort consisted of 330 patients: 106 SP (32.12%), 61 SPg (18.48%), 82 TP (24.85%), and 81 TPg (24.55%). No donor site complications occurred. TPg resulted in seven graft necroses (8.64%), and 22 reported gustatory sweating (27.20% vs. 10 TP patients (12.2%), P = 0.016); SPg resulted in two necroses (3.28%). There were no other statistically significant differences in complication rates. Graft recipients receiving adjuvant radiation were more likely to develop necrosis (odds ratio [OR] 4.60, 95% confidence interval [CI] , 1.16–18.27, P = .0194). Patients who developed gustatory sweating were 8.38 years younger (95% CI 2.66–14.10, P = 0.002, follow‐up time  〉  48 days). Grafting did not increase operative times (TP/TPg: mean = 275.91/263.65 minutes, standard error of the mean = 41.96/33.75, P = 0.822). Conclusion An abdominal dermal‐fat graft is an excellent reconstructive choice for a parotidectomy defect and is not associated with increased complication rates or prolonged operative time. Level of Evidence 4 Laryngoscope , 130:2144–2147, 2020
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    URL: Article
    DOI: 10.1002/lary.v130.9
    DOI: 10.1002/lary.28466
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2026089-1
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  • 9
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    Sinonasal Osteosarcoma: Report of 14 New Cases and Systematic Review of the Literature
    Georg Thieme Verlag KG ; 2021
    In:  Journal of Neurological Surgery Part B: Skull Base Vol. 82, No. S 03 ( 2021-07), p. e138-e147
    Details
    In: Journal of Neurological Surgery Part B: Skull Base, Georg Thieme Verlag KG, Vol. 82, No. S 03 ( 2021-07), p. e138-e147
    Abstract: Objective The objective of this study is to describe the clinical presentation, tumor characteristics, natural history, and treatment patterns of sinonasal osteosarcoma. Methods Fourteen patients who had been treated for osteosarcoma of the nasal cavity and paranasal sinuses at a tertiary care center were reviewed. In addition, a systematic review of the literature for osteosarcoma of the sinonasal cavity was performed. Results In a systematic review, including 14 patients from the authors' institution, 53 total studies including 88 patients were assessed. Median follow-up was 18 months (interquartile range: 8–39 months). The most common presenting symptoms were facial mass or swelling (34%), and nasal obstruction (30%). The most common paranasal sinus involved by tumor was the maxillary sinus (64%), followed by the ethmoid sinuses (52%). The orbit (33%), dura (13%) and infratemporal fossa (10%) were the most common sites of local invasion. The majority of patients underwent surgery followed by adjuvant therapy (52.4%). Increasing age was associated with decreased overall survival rate (unit risk ratio [95% confidence interval (CI)] = 1.02 [1.003–1.043] ; p = 0.0216) and T4 disease was associated with decreased disease-specific survival rate (hazard ratio [HR] = 2.87; p = 0.0495). The 2- and 5-year overall survival rates were 68 and 40%, respectively, while 2- and 5-year disease-specific survival rates were 71% and 44%, respectively. Conclusion Sinonasal osteosarcomas are uncommon tumors and can pose a significant therapeutic challenge. Increasing age and T4 disease are associated with worse prognosis. This disease usually warrants consultation by a multidisciplinary team and consideration of multimodality therapy.
    Type of Medium: Online Resource
    ISSN: 2193-6331 , 2193-634X
    URL: Article
    DOI: 10.1055/s-0040-1701221
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2021
    detail.hit.zdb_id: 2653367-4
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  • 10
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    Abstract 34: A Drosophila approach to personalized cancer therapeutics
    American Association for Cancer Research (AACR) ; 2016
    In:  Clinical Cancer Research Vol. 22, No. 1_Supplement ( 2016-01-01), p. 34-34
    Details
    In: Clinical Cancer Research, American Association for Cancer Research (AACR), Vol. 22, No. 1_Supplement ( 2016-01-01), p. 34-34
    Abstract: Personalized cancer genomics is providing unprecedented access into the genetic complexity and diversity of human tumors. The next challenge is to utilize this information to establish effective therapeutics. Functional interrogation of cancer genomes using genetic model systems provides a powerful step towards realizing this goal. To capture the genetic complexity and diversity of human tumors, we identified the most frequently observed double, triple and quadruple combinations of mutations in human colon cancer genomes generated by TCGA. We used this information to generate the corresponding multigenic models in Drosophila and investigated the tumorigenic and metastatic potential of these 32 models by activating transgenes specifically in the adult Drosophila colon. These models recapitulate key features of human cancer, many of which arise as emergent properties of multigenic combinations. Importantly, we found that multigenic models were more resistant to targeted drugs and compounds: 12/16 of the targeted agents we tested were effective against rasG12V alone while 0/16 were effective against the four-hit model rasG12V p53RNAi ptenRNAi apcRNAi. We identified a potential mechanism for resistance to PI3K pathway inhibitors as well as biomarkers for single agent response and resistance. With this in hand, we developed a combination therapy that overcame resistance of our four-hit model to single agent PI3K pathway inhibitors. We validated our findings in human colorectal cancer cell lines including xenografts as well as 3D colospheres and allografts derived from genetically engineered mouse colorectal cancer models. Overall, our models provide an excellent opportunity to study tumorigenesis and metastasis in the context of the whole animal and explore compound effects on a genetically diverse set of models. Through these efforts we have developed a platform designed to screen large numbers of personalized fly models in a rapid and cost effective manner. We are now leveraging these technologies—using personalized fly models to identify personalized drug cocktails—to treat individual patients in a clinical study focusing on medullary thyroid cancer and colorectal cancer. Briefly, we first generate high quality genomic profiles for our patients and use this information to build a personalized fly model for each patient. These models are then screened against a large library of FDA approved drugs in an iterative manner to identify drug combinations specifically tailored to each patient. Our approach to personalized cancer therapeutics leverages sophisticated genetic tools and high throughput drug screening methods in Drosophila to address tumor and whole body complexities and provides a unique opportunity to identify novel treatment options for individual patients based on functional exploration of their tumor genomes. Citation Format: Erdem Bangi, Claudio Murgia, Alexander Teague, Peter Smibert, Jessica Esernio, Nelson Gruszczynski, Caitlyn Yeykal, Owen Sansom, Ross Cagan. A Drosophila approach to personalized cancer therapeutics. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Integrating Clinical Genomics and Cancer Therapy; Jun 13-16, 2015; Salt Lake City, UT. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(1_Suppl):Abstract nr 34.
    Type of Medium: Online Resource
    ISSN: 1078-0432 , 1557-3265
    URL: Article
    DOI: 10.1158/1557-3265.PMSCLINGEN15-34
    RVK:
    XA 36791
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2016
    detail.hit.zdb_id: 1225457-5
    detail.hit.zdb_id: 2036787-9
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