In:
Tissue Antigens, Wiley, Vol. 82, No. 6 ( 2013-12), p. 387-396
Abstract:
Four hundred and ninety‐five patients (390 and 105 grafted from unrelated and sibling (SIB) donors, respectively) and their donors were analyzed for the impact of interleukin‐10 ( IL ‐10 ) promoter genotype [rs18000896 (−1082 G/A), rs18000871 (−819 C/T) and rs18000872 (−592 C/A)] on the outcome of hematopoietic stem cell transplantation ( HSCT ). Patients having ACC haplotype were at a lower risk of acute graft versus host disease (aGvHD, grade 〉 I) if transplanted from human leukocyte antigen ( HLA ) well‐matched (10/10) unrelated donors (20/135 vs 39/117, P 〈 0.001, P corr = 0.002), which was not seen if patients were transplanted from either sibling (SIB) or poorly matched ( 〈 10/10) unrelated donors (MUD). In addition, GCC haplotype positive recipients of unrelated donor transplants tended to be more susceptible to aGvHD (68/199 vs 39/169, P = 0.019, P corr = 0.057). Multivariate logistic regression analysis in the MUD transplanted group showed that donor–recipient human leukocyte antigen ( HLA ) mismatch [odds ratio ( OR ) = 3.937, P = 0.001] and a lack of ACC haplotype in recipients ( OR = 0.417, P = 0.013) played a significant role as independent risk factors of aGvHD grade 〉 I. ACC carriers had higher proportions of FoxP3 + lymphocytes gated in CD4 + lymphocytes as compared with patients with other IL ‐10 haplotypes. It was seen at the time of hematological recovery (mean ± SEM : 3.80 ± 0.91% vs 2.06 ± 0.98%, P = 0.012) and 2 weeks later (5.32 ± 0.87% vs 2.50 ± 0.83%, P = 0.013); −592 C/A polymorphism was separately analyzed and it was found that AA homozygotes tended to have a higher incidence of aGvHD (8/15 vs 116/456, P = 0.034) and low proportions of FoxP3 CD4 + lymphocytes in blood (0.43 ± 0.22% vs 4.32 ± 0.71%, P = 0.051) measured 2 weeks after hematological recovery. Functional IL ‐10 polymorphism associated features influenced the risk of aGvHD with a positive effect of ACC on the pool of Treg in blood.
Type of Medium:
Online Resource
ISSN:
0001-2815
,
1399-0039
DOI:
10.1111/tan.2013.82.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
1498140-3
detail.hit.zdb_id:
2844321-4
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