In:
European Journal of Organic Chemistry, Wiley, Vol. 2012, No. 5 ( 2012-02), p. 1039-1046
Abstract:
Eight new diarylheptanoid glucosides 1 – 8 have been isolated from the leaves of Pyrostria major (A. Rich & DC.) Cavaco [syn. Canthium major (A. Rich & DC.)] Cavaco. Their structures were determined by 1D and 2D NMR spectroscopic and HRMS analyses. The absolute configurations of the diarylheptanoids 1 – 4 were determined to be 3 S and 5 S by the application of the CD exciton chirality method to the corresponding 3,5‐bis( p ‐bromobenzoyl) ( 1 – 3 ) and 3,5‐bis( p ‐dimethylaminobenzoyl) ( 4 ) derivatives. Their antiparasitic activities against Plasmodium falciparum , Leishmania donovani (amastigote forms), and Trypanosoma brucei (trypomastigote bloodstream forms) as well as their cytotoxic activities against the HL‐60, KB, and MRC5 cell lines of naturally occurring diarylheptanoid glucosides and their derivatives are reported.
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2012.5
DOI:
10.1002/ejoc.201101414
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
1475010-7
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