In:
Journal of Biomedicine and Biotechnology, Hindawi Limited, Vol. 2004, No. 2 ( 2004), p. 73-78
Abstract:
Tetranectin is a plasminogen kringle 4 domain-binding protein present in plasma and various tissue locations. Decreased plasma tetranectin or increased tetranectin in stroma of cancers correlates with cancer progression and adverse prognosis. A possible mechanism through which tetranectin could influence cancer progression is by altering activities of plasminogen or the plasminogen fragment, angiostatin. Tetranectin was found to bind to the kringle 1-4 form of angiostatin (AST K1-4 ). In addition, tetranectin inhibited binding of plasminogen or AST K1-4 to extracellular matrix (ECM) deposited by endothelial cells. Finally, tetranectin partially counteracted the ability of AST K1-4 to inhibit proliferation of endothelial cells. This latter effect of tetranectin was specific for AST K1-4 since it did not counteract the antiproliferative activities of the kringle 1-3 form of angiostatin (AST K1-3 ) or endostatin. These findings suggest that tetranectin may modulate angiogenesis through interactions with AST.
Type of Medium:
Online Resource
ISSN:
1110-7243
,
1110-7251
DOI:
10.1155/S1110724304307096
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2004
detail.hit.zdb_id:
2698540-8
detail.hit.zdb_id:
2512507-2
SSG:
12
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