In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 71, No. 18_Supplement ( 2011-09-15), p. A14-A14
Abstract:
Tumor microenvironment plays an essential role in modulating and supporting tumor growth. Solid tumors are frequently infiltrated with innate immune cells as illustrated by the strong macrophages infiltration observed in breast tumors. In fact, infiltrating macrophages in breast tumors are associated with poor prognosis. IL-1beta (IL-1 b) is a proinflammatory cytokine produced mostly by macrophages and dendritic cells which detection in advance breast tumor stage is also correlated with bad prognosis. Furthermore, mouse studies using the orthotopic implantation of the mammary tumor cell line 4T1 have suggested a role for IL-1b in tumor growth and vascularization. IL-1b is a peculiar cytokine as its production is tightly controlled. First, proinflammatory signals induce the production of the proIL-1 b. To be active, the cytokine has to be cleaved by the caspase-1 within a complex named the inflammasome. Finally the cleaved cytokine is secreted outside the cells. By and large, the inflammasome is composed of a scaffold receptor, for instance NLRP3, an adaptor, ASC, and caspase-1. The NLRP3 inflammasome is mainly expressed by macrophages and dendritic cells and gets activated upon detection of pattern-associated molecular pattern but also danger-associated molecular pattern such as extracellular ATP or uric acid. As the inflammasome controls the biological activity of IL-1b, we speculated that the inflammasome should play an important role in the breast tumor microenvironment. To test our hypothsesis, we used the mouse mammary model of breast cancer using orthotopic implantation of 4T1 cells within the mammary gland of either wild-type or inflammasome deficient mice. Our results show that tumor growth is delayed in caspase-1 deficient mice suggesting that the presence of the inflammasome in the tumor microenvironment supports tumor growth. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the Second AACR International Conference on Frontiers in Basic Cancer Research; 2011 Sep 14-18; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2011;71(18 Suppl):Abstract nr A14.
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.FBCR11-A14
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2011
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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