In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 19, No. 7 ( 2023-7-10), p. e1011479-
Abstract:
Buruli ulcer is a chronic infectious disease caused by Mycobacterium ulcerans . The pathogen persistence in host skin is associated with the development of ulcerative and necrotic lesions leading to permanent disabilities in most patients. However, few of diagnosed cases are thought to resolve through an unknown self-healing process. Using in vitro and in vivo mouse models and M . ulcerans purified vesicles and mycolactone, we showed that the development of an innate immune tolerance was only specific to macrophages from mice able to heal spontaneously. This tolerance mechanism depends on a type I interferon response and can be induced by interferon beta. A type I interferon signature was further detected during in vivo infection in mice as well as in skin samples from patients under antibiotics regiment. Our results indicate that type I interferon-related genes expressed in macrophages may promote tolerance and healing during infection with skin damaging pathogen.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1011479
DOI:
10.1371/journal.ppat.1011479.g001
DOI:
10.1371/journal.ppat.1011479.g002
DOI:
10.1371/journal.ppat.1011479.g003
DOI:
10.1371/journal.ppat.1011479.g004
DOI:
10.1371/journal.ppat.1011479.g005
DOI:
10.1371/journal.ppat.1011479.g006
DOI:
10.1371/journal.ppat.1011479.s001
DOI:
10.1371/journal.ppat.1011479.s002
DOI:
10.1371/journal.ppat.1011479.s003
DOI:
10.1371/journal.ppat.1011479.s004
DOI:
10.1371/journal.ppat.1011479.s005
DOI:
10.1371/journal.ppat.1011479.s006
DOI:
10.1371/journal.ppat.1011479.s007
DOI:
10.1371/journal.ppat.1011479.s008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2205412-1
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