In:
Diabetes and Vascular Disease Research, SAGE Publications, Vol. 11, No. 5 ( 2014-09), p. 343-351
Abstract:
The aim of this study was to determine whether high fitness attenuates the defects in left ventricular (LV) structure, function and triglyceride (TG) content in patients with type 2 diabetes mellitus (T2DM). Materials and methods: Patients ( n = 74) with T2DM and ≥1 additional cardiac risk factor were recruited to participate in this cross-sectional study. Outcome measures of interest were LV structure and function by magnetic resonance imaging (MRI) and myocardial TG content by 1 H-magnetic resonance spectroscopy (MRS). The primary exposure variable was cardiorespiratory fitness defined by peak oxygen consumption scaled to fat-free mass (FFM; VO 2peak-FFM ). Results: Mean age was 53.5 years; 42.9% were women and mean glycosylated haemoglobin (HbA 1c ) was 8.0% with the mean duration of T2DM 8.2 years. VO 2peak-FFM was crudely associated with both LV end systolic ( r = 0.35, p = 0.002) and diastolic volumes ( r = 0.32, p = 0.004), but not with ejection fraction ( r = −0.15, p = 0.206), myocardial TG ( r = −0.04, p = 0.734) or early diastolic peak filling rate (PFR; r = −0.01, p = 0.887). In multiple linear regression analyses, among measures of LV structure/function, VO 2peak-FFM was independently associated only with LV end-diastolic volume (EDV) ( β = 1.037, p = 0.038). Conclusion: In individuals with T2DM at increased cardiovascular (CV) risk, cardiorespiratory fitness is not associated with LV morphology, function or myocardial TG content.
Type of Medium:
Online Resource
ISSN:
1479-1641
,
1752-8984
DOI:
10.1177/1479164114540924
Language:
English
Publisher:
SAGE Publications
Publication Date:
2014
detail.hit.zdb_id:
2250797-8
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