In:
Bharati Vidyapeeth Medical Journal, Ketaki Prakashan Private Limited, Vol. 2, No. 3 ( 2022-9-30), p. 3-7
Abstract:
Background: The herbs/plants are used in traditional and folk medicines worldwide for treating wounds and burns. Animal models help to understand the tissue repair process and corroborate various approaches to formulate therapy for wound healing. Objective: To determine the efficacy of 'Anuradha Oil 11' (AO11) on incision wound healing in Wistar rats. Methods: There were four groups formed based on the treatment received as Test group (AO11), Control group, Standard I Hydroheal group,and Standard II Curcumin group. Six female rats were used per group in this study. Linear-length paravertebral incisions were made through the shaven skin. Three surgical sutures were placed, each one cm apart. A 0.1 mL of test material AO11, 0.1 mL of standard I hydroheal, and 0.1 mLof 1% solution of standard II curcumin respectively were applied on the wound once daily for nine days. The control group wound remained untreated. On day nine (post-wound), all the sutures were removed. On day 11, all the animals were anesthetized, and the breaking strength of previously wound-treated skin was measured using a tensiometer. Results: All the animals appeared normal and showed no clinical signs of intoxication till the end of the study. The test group 2 2 showed a higher tensile strength (48.3 g/mm ) required to open the wound when compared to the control group (38.14 g/mm ).The increase in tensile strength was statistically significant between the test (p 〈 0.01) and both the standard groups (p 〈 0.05). There was no statistically significant change in the body weight of all the animals. No mortality was observed in any of the groups. Conclusion:The study concluded that the test material AO11 showed an increase in efficacy compared to control and is safe for use.
Type of Medium:
Online Resource
ISSN:
2582-9874
DOI:
10.56136/BVMJ/vol_2_3
DOI:
10.56136/BVMJ/2022_00076
Language:
Unknown
Publisher:
Ketaki Prakashan Private Limited
Publication Date:
2022
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