In:
Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 31, No. 1A_suppl ( 1983-01), p. 235-237
Abstract:
The number, intracellular distribution, and staining characteristics of human hepatocellular peroxisomes that had been made visible by cytochemical staining for catalase were evaluated in biopsies from 75 patients with hepatic, inflammatory, or malignant disease and ten normal individuals. Intensity of staining was found to be proportional to enzymatic activity by microspectrophotometry. Scanning transmission electron microscopy (STEM) image analysis demonstrated an inverse relationship between peroxisomal size and contrast. Peroxisomes were more abundant, and often concentrated in a perinuclear configuration in cholestatic and cirrhotic livers. Decreased peroxisomal staining was common in cholestasis, cirrhosis, hepatitis, and in almost all patients with malignancies, both with and without hepatic metastases.
Type of Medium:
Online Resource
ISSN:
0022-1554
,
1551-5044
DOI:
10.1177/31.1A_SUPPL.6186727
Language:
English
Publisher:
SAGE Publications
Publication Date:
1983
detail.hit.zdb_id:
1421306-0
SSG:
12
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