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  • 1
    Online Resource
    Online Resource
    Spike-related haemodynamic responses overlap with high frequency oscillations in patients with focal epilepsy
    Oxford University Press (OUP) ; 2018
    In:  Brain Vol. 141, No. 3 ( 2018-03-01), p. 731-743
    Details
    In: Brain, Oxford University Press (OUP), Vol. 141, No. 3 ( 2018-03-01), p. 731-743
    Type of Medium: Online Resource
    ISSN: 0006-8950 , 1460-2156
    URL: Article
    DOI: 10.1093/brain/awx383
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2018
    detail.hit.zdb_id: 1474117-9
    SSG: 12
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  • 2
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    Psychogenic nonepileptic seizures in patients with surgically treated temporal lobe epilepsy: Presurgical and de novo postsurgical occurrence
    Elsevier BV ; 2017
    In:  Epilepsy & Behavior Vol. 75 ( 2017-10), p. 252-255
    Details
    In: Epilepsy & Behavior, Elsevier BV, Vol. 75 ( 2017-10), p. 252-255
    Type of Medium: Online Resource
    ISSN: 1525-5050
    URL: Article
    DOI: 10.1016/j.yebeh.2017.08.015
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
    detail.hit.zdb_id: 2018844-4
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  • 3
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    Online Resource
    Patient specific prediction of temporal lobe epilepsy surgical outcomes
    Wiley ; 2021
    In:  Epilepsia Vol. 62, No. 9 ( 2021-09), p. 2113-2122
    Details
    In: Epilepsia, Wiley, Vol. 62, No. 9 ( 2021-09), p. 2113-2122
    Abstract: Drug‐resistant temporal lobe epilepsy (TLE) is the most common type of epilepsy for which patients undergo surgery. Despite the best clinical judgment and currently available prediction algorithms, surgical outcomes remain variable. We aimed to build and to evaluate the performance of multidimensional Bayesian network classifiers (MBCs), a type of probabilistic graphical model, at predicting probability of seizure freedom after TLE surgery. Methods Clinical, neurophysiological, and imaging variables were collected from 231 TLE patients who underwent surgery at the University of California, San Francisco (UCSF) or the Montreal Neurological Institute (MNI) over a 15‐year period. Postsurgical Engel outcomes at year 1 (Y1), Y2, and Y5 were analyzed as primary end points. We trained an MBC model on combined data sets from both institutions. Bootstrap bias corrected cross‐validation (BBC‐CV) was used to evaluate the performance of the models. Results The MBC was compared with logistic regression and Cox proportional hazards according to the area under the receiver‐operating characteristic curve (AUC). The MBC achieved an AUC of 0.67 at Y1, 0.72 at Y2, and 0.67 at Y5, which indicates modest performance yet superior to what has been reported in the state‐of‐the‐art studies to date. Significance The MBC can more precisely encode probabilistic relationships between predictors and class variables (Engel outcomes), achieving promising experimental results compared to other well‐known statistical methods. Multisite application of the MBC could further optimize its classification accuracy with prospective data sets. Online access to the MBC is provided, paving the way for its use as an adjunct clinical tool in aiding pre‐operative TLE surgical counseling.
    Type of Medium: Online Resource
    ISSN: 0013-9580 , 1528-1167
    URL: Issue
    URL: Article
    DOI: 10.1111/epi.v62.9
    DOI: 10.1111/epi.17002
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2002194-X
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  • 4
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    Online Resource
    Networks in Temporal Lobe Epilepsy
    Elsevier BV ; 2020
    In:  Neurosurgery Clinics of North America Vol. 31, No. 3 ( 2020-07), p. 309-317
    Details
    In: Neurosurgery Clinics of North America, Elsevier BV, Vol. 31, No. 3 ( 2020-07), p. 309-317
    Type of Medium: Online Resource
    ISSN: 1042-3680
    URL: Article
    DOI: 10.1016/j.nec.2020.02.001
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
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  • 5
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    Online Resource
    Automated seizure detection accuracy for ambulatory EEG recordings
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Neurology Vol. 92, No. 14 ( 2019-04-02), p. e1540-e1546
    Details
    In: Neurology, Ovid Technologies (Wolters Kluwer Health), Vol. 92, No. 14 ( 2019-04-02), p. e1540-e1546
    Abstract: To investigate the accuracy of preselected software automatic seizure files to detect at least one seizure per study in prolonged ambulatory EEG recording. Methods All the prolonged ambulatory EEG recordings ( 〉 24 hours) read at the Northwestern Memorial Hospital from January 2013 to October 2017 were included. We selected only the first study of each patient. We reviewed the studies entirely, and processed the recordings through 1 of 3 different detection software that are commercially available (Persyst 11, Persyst 12, and Gotman TM Event Detection). The proportion of patients with at least one electrographic seizure (≥10 seconds) correctly identified by a seizure detector was calculated. Finally, we evaluated whether the type of seizure (focal vs generalized) may affect the chances of being automatically detected. Results We read 1,478 ambulatory EEG studies entirely (2,323 days of EEG recording; average 1.6 d/study). From the first study of each patient (1,257 studies), we found electrographic seizures in 70 (5.6%) studies. In 37 of 70 patients (53%), the automatic detectors correctly identified at least one seizure. Detections happened slightly more frequently in generalized seizures (14/20, 70%) compared to focal seizures (23/50, 46%) ( p = 0.06). Conclusion Seizures were found in 5.6% of the studies. Automatic seizure detectors identified at least one electrographic seizure in only 53% of the studies. They performed slightly better detecting generalized than focal seizures. Therefore, the review of only automatically selected segments may be of decreased value to identify seizures, in particular when focal seizures are suspected.
    Type of Medium: Online Resource
    ISSN: 0028-3878 , 1526-632X
    URL: Article
    DOI: 10.1212/WNL.0000000000007237
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
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  • 6
    Online Resource
    Online Resource
    Ambulatory EEG to Classify the Epilepsy Syndrome
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Journal of Clinical Neurophysiology Vol. 38, No. 2 ( 2021-03), p. 87-91
    Details
    In: Journal of Clinical Neurophysiology, Ovid Technologies (Wolters Kluwer Health), Vol. 38, No. 2 ( 2021-03), p. 87-91
    Abstract: Recording of interictal epileptiform discharges to classify the epilepsy syndrome is one of the most common indications for ambulatory EEG. Ambulatory EEG has superior sampling compared with standard EEG recordings and advantages in terms of cost-effectiveness and convenience compared with a prolonged inpatient EEG study. Ambulatory EEG allows for EEG recording in all sleep stages and transitional states, which can be very helpful in capturing interictal epileptiform discharges. In the absence of interictal epileptiform discharges or in patients with atypical events, the characterization of an epilepsy syndrome may require recording of the habitual events. Diagnostic ambulatory EEG can be a useful alternative to inpatient video-EEG monitoring in a selected number of patients with frequent events who do not require medication taper or seizure testing for surgical localization.
    Type of Medium: Online Resource
    ISSN: 0736-0258
    URL: Article
    DOI: 10.1097/WNP.0000000000000678
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2065729-8
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  • 7
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    Ambulatory EEG-video
    Elsevier BV ; 2024
    In:  Epilepsy & Behavior Vol. 151 ( 2024-02), p. 109615-
    Details
    In: Epilepsy & Behavior, Elsevier BV, Vol. 151 ( 2024-02), p. 109615-
    Type of Medium: Online Resource
    ISSN: 1525-5050
    URL: Article
    DOI: 10.1016/j.yebeh.2023.109615
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 2018844-4
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  • 8
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    Postsurgical seizure outcome in temporal lobe epilepsy patients with normal or subtle, nonspecific MRI findings
    Journal of Neurosurgery Publishing Group (JNSPG) ; 2022
    In:  Journal of Neurosurgery Vol. 137, No. 2 ( 2022-08-01), p. 442-448
    Details
    In: Journal of Neurosurgery, Journal of Neurosurgery Publishing Group (JNSPG), Vol. 137, No. 2 ( 2022-08-01), p. 442-448
    Abstract: The authors’ objective was to report postsurgical seizure outcome of temporal lobe epilepsy (TLE) patients with normal or subtle, nonspecific MRI findings and to identify prognostic factors related to seizure control after surgery. METHODS This was a retrospective study of patients who underwent surgery from 1999 to 2014 at two comprehensive epilepsy centers. Patients with a clear MRI lesion according to team discussion and consensus were excluded. Presurgical information, surgery details, pathological data, and postsurgical outcomes were retrospectively collected from medical charts. Multiple logistic regression analysis was used to assess the effect of clinical, surgical, and neuroimaging factors on the probability of Engel class I (favorable) versus class II–IV (unfavorable) outcome at last follow-up. RESULTS The authors included 73 patients (59% were female; median age at surgery 35.9 years) who underwent operations after a median duration of epilepsy of 13 years. The median follow-up after surgery was 30.6 months. At latest follow-up, 44% of patients had Engel class I outcome. Favorable prognostic factors were focal nonmotor aware seizures and unilateral or no spikes on interictal scalp EEG. CONCLUSIONS Favorable outcome can be achieved in a good proportion of TLE patients with normal or subtle, nonspecific MRI findings, particularly when presurgical investigation suggests a rather circumscribed generator. Presurgical factors such as the presence of focal nonmotor aware seizures and unilateral or no spikes on interictal EEG may indicate a higher probability of seizure freedom.
    Type of Medium: Online Resource
    ISSN: 0022-3085 , 1933-0693
    URL: Article
    DOI: 10.3171/2021.10.JNS2127
    RVK:
    XA 10000
    RVK:
    XA 55270
    Language: Unknown
    Publisher: Journal of Neurosurgery Publishing Group (JNSPG)
    Publication Date: 2022
    detail.hit.zdb_id: 2026156-1
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  • 9
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    Online Resource
    In vivo metabotropic glutamate receptor type 5 abnormalities localize the epileptogenic zone in mesial temporal lobe epilepsy
    Wiley ; 2019
    In:  Annals of Neurology Vol. 85, No. 2 ( 2019-02), p. 218-228
    Details
    In: Annals of Neurology, Wiley, Vol. 85, No. 2 ( 2019-02), p. 218-228
    Abstract: Surgical specimens from patients with mesial temporal lobe epilepsy (MTLE) show abnormalities in tissue concentrations of metabotropic glutamate receptor type 5 (mGluR5). To clarify whether these abnormalities are specific to the epileptogenic zone (EZ), we characterized in vivo whole‐brain mGluR5 availability in MTLE patients using positron emission tomography (PET) and [ 11 C]ABP688, a radioligand that binds specifically to the mGluR5 allosteric site. Methods Thirty‐one unilateral MTLE patients and 30 healthy controls underwent [ 11 C]ABP688 PET. We compared partial volume corrected [ 11 C]ABP688 nondisplaceable binding potentials (BP ND ) between groups using region‐of‐interest and whole‐brain voxelwise analyses. [ 18 F]Fluorodeoxyglucose (FDG) PET was acquired in 15 patients, for whom we calculated asymmetry indices of [ 11 C]ABP688 BP ND and [ 18 F]FDG uptake to compare lateralization and localization differences. Results [ 11 C]ABP688 BP ND was focally reduced in the epileptogenic hippocampal head and amygdala ( p 〈 0.001). Patients with hippocampal atrophy showed more extensive abnormalities, including the ipsilateral temporal neocortex ( p = 0.006). [ 11 C]ABP688 BP ND showed interhemispheric differences of higher magnitude and discriminated the epileptogenic structures more accurately when compared to [ 18 F]FDG uptake, which showed more widespread hypometabolism. Among 23 of 25 operated patients with 〉 1 year of follow‐up, 13 were seizure‐free (Engel Ia) and showed significantly lower [ 11 C]ABP688 BP ND in the ipsilateral entorhinal cortex. Interpretation [ 11 C]ABP688 PET provides a focal biomarker for the EZ in MTLE with higher spatial accuracy compared to [ 18 F]FDG PET. Focally reduced mGluR5 availability in the EZ might reflect receptor internalization or conformational changes in response to excessive extracellular glutamate, supporting a potential role for mGluR5 as therapeutic target in human MTLE. Ann Neurol 2019; 1–11 ANN NEUROL 2019;85:218–228.
    Type of Medium: Online Resource
    ISSN: 0364-5134 , 1531-8249
    URL: Issue
    URL: Article
    DOI: 10.1002/ana.v85.2
    DOI: 10.1002/ana.25404
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2037912-2
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  • 10
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    Online Resource
    In vivo hippocampal cornu ammonis 1–3 glutamatergic abnormalities are associated with temporal lobe epilepsy surgery outcomes
    Wiley ; 2021
    In:  Epilepsia Vol. 62, No. 7 ( 2021-07), p. 1559-1568
    Details
    In: Epilepsia, Wiley, Vol. 62, No. 7 ( 2021-07), p. 1559-1568
    Abstract: Previous positron emission tomography (PET) studies using [ 11 C]ABP688 show reduced metabotropic glutamate receptor type 5 (mGluR5) allosteric binding site availability in the epileptogenic hippocampus of mesial temporal lobe epilepsy (MTLE) patients. However, the link between mGluR5 abnormalities and postsurgical outcomes remains unclear. Here, we test whether reduced PET [ 11 C]ABP688 binding in cornu ammonis (CA) sectors more vulnerable to glutamatergic excitotoxicity relates to surgical outcomes. Methods We obtained magnetic resonance imaging (MRI) and [ 11 C]ABP688‐PET from 31 unilateral MTLE patients and 30 healthy controls. MRI hippocampal subfields were segmented using FreeSurfer. To respect the lower PET special resolution, MRI‐derived anatomical subfields were combined into CA1–3, CA4/dentate gyrus, and Subiculum. Partial volume corrected [ 11 C]ABP688 nondisplaceable binding potential (BP ND ) values were averaged across each subfield, and Z ‐scores were calculated. Subfield [ 11 C]ABP688‐BP ND was compared between seizure‐free and non‐seizure‐free patients. In addition, we also assessed subfield volumes and [ 18 F]fluorodeoxyglucose (FDG) uptake in each clinical group. Results MTLE [ 11 C]ABP688‐BP ND was reduced in ipsilateral (epileptogenic) CA1–3 and CA4/dentate‐gyrus ( p   〈  .001, 95% confidence interval [CI] = .29–.51) compared to controls, with no difference in Subiculum. [ 11 C]ABP688‐BP ND and subfield volumes were compared between seizure‐free (Engel IA, n  = 13) and non‐seizure‐free patients (Engel IC–III, n  = 10). In ipsilateral CA1–3 only, [ 11 C]ABP688‐BP ND was lower in seizure‐free patients than in non‐seizure‐free patients ( p  = .012, 95% CI = 1.46–11.0) independently of volume. A subset analysis of 12 patients with [ 11 C]ABP688‐PET+[ 18 F]FDG‐PET showed no between‐group significant difference in [ 18 F]FDG uptake, whereas CA1–3 [ 11 C]ABP688‐BP ND remained significantly lower in the seven of 12 seizure‐free patients ( p  = .03, 95% CI = −3.13 to −.21). Significance Reduced mGluR5 allosteric site availability in hippocampal CA1–3, measured in vivo by [ 11 C]ABP688‐PET, is associated with postsurgery seizure freedom independent of atrophy or hypometabolism. Information derived from hippocampal CA1–3 [ 11 C]ABP688‐PET is a promising imaging biomarker potentially impactful in surgical decisions for MRI‐negative/PET‐negative MTLE patients.
    Type of Medium: Online Resource
    ISSN: 0013-9580 , 1528-1167
    URL: Issue
    URL: Article
    DOI: 10.1111/epi.v62.7
    DOI: 10.1111/epi.16952
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2002194-X
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