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  • 1
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    Otologic Trauma
    Elsevier BV ; 2020
    In:  Operative Techniques in Otolaryngology-Head and Neck Surgery Vol. 31, No. 4 ( 2020-12), p. 353-364
    Details
    In: Operative Techniques in Otolaryngology-Head and Neck Surgery, Elsevier BV, Vol. 31, No. 4 ( 2020-12), p. 353-364
    Type of Medium: Online Resource
    ISSN: 1043-1810
    URL: Article
    DOI: 10.1016/j.otot.2020.10.013
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2135189-2
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  • 2
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    Virtual Reality as Distraction Analgesia and Anxiolysis for Pediatric Otolaryngology Procedures
    Wiley ; 2021
    In:  The Laryngoscope Vol. 131, No. 5 ( 2021-05)
    Details
    In: The Laryngoscope, Wiley, Vol. 131, No. 5 ( 2021-05)
    Abstract: While virtual reality (VR) has been used as analgesia and anxiolysis for invasive procedures, no literature exists on the use of VR in the pediatric otolaryngology setting. The purpose of this study was to determine the efficacy of VR in reducing pain and anxiety for pediatric otolaryngology patients. Study Design Randomized controlled trial. Methods A total of 53 patients aged 7–17 undergoing in‐office nasal endoscopies were included. Patients were randomized to receive VR or standard of care. Procedural pain, anxiety, and satisfaction scores were recorded from patients and caregivers. The physician filled out a childhood emotional manifestation scale (CEMS). Results Patients in VR group reported a significant decrease in pain (0.80 ± 1.06 vs. 2.26 ± 2.38, P = .018) and anxiety (9.50 ± 12.48 vs. 38.48 ± 29.83, P = .0002) and increase in procedural satisfaction (6.40 ± 0.77 vs. 4.74 ± 1.74, P = .0002) compared to patients in control group. CEMS scores were significantly reduced in VR group (5.15 ± 0.46 vs. 9.64 ± 5.66, P = .0001) and caregiver anxiety levels were significantly reduced in VR group (11.50 ± 17.67 vs. 27.39 ± 30.48, P = .041) compared to control group. There were no reported side effects. Procedural time did not significantly differ between groups. Conclusions For pediatric otolaryngology patients undergoing in‐office nasal endoscopies, VR is a safe and effective form of distraction analgesia and anxiolysis, significantly reducing pain and increasing procedural satisfaction for patients. In addition, VR significantly reduces anxiety for both patients and caregivers without disrupting procedural efficiency and workflow. Level of Evidence 2. Laryngoscope , 131:E1714–E1721, 2021
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    URL: Article
    DOI: 10.1002/lary.v131.5
    DOI: 10.1002/lary.29148
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2026089-1
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  • 3
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    The value of 68 Gallium‐DOTATATE PET / CT in sinonasal neuroendocrine tumor management: A case series
    Wiley ; 2021
    In:  Head & Neck Vol. 43, No. 6 ( 2021-06)
    Details
    In: Head & Neck, Wiley, Vol. 43, No. 6 ( 2021-06)
    Abstract: 68 Gallium‐DOTATATE ( 68 Ga‐DOTATATE) is a somatostatin analog used as a PET tracer to successfully identify neuroendocrine tumors (NETs). Due to the rarity of sinonasal NETs, there are few recommendations for 68 Ga‐DOTATATE imaging in these patients. Methods We discussed the impact of 68 Ga‐DOTATATE imaging on the management of six sinonasal NET cases and reviewed existing literature. Results 68 Ga‐DOTATATE PET/CT revealed an unknown primary in one case and identified metastatic disease in a primary sinonasal small cell neuroendocrine carcinoma (SNEC) patient missed on conventional imaging. In two esthesioneuroblastoma (ENB) patients, 68 Ga‐DOTATATE detected abnormal radiotracer uptake not present on 18F‐FDG PET/CT and identified a patient for treatment with 177 Lu‐DOTATATE. Conclusions This is the one of the first few reports, and the largest series to our knowledge, demonstrating the utility of 68 Ga‐DOTATATE imaging for primary sinonasal SNEC and ENB. Further study is required to determine its role in sinonasal NET management.
    Type of Medium: Online Resource
    ISSN: 1043-3074 , 1097-0347
    URL: Issue
    URL: Article
    DOI: 10.1002/hed.v43.6
    DOI: 10.1002/hed.26695
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2001440-5
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  • 4
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    Identification of Somatic Structural Variants in Solid Tumors by Optical Genome Mapping
    MDPI AG ; 2021
    In:  Journal of Personalized Medicine Vol. 11, No. 2 ( 2021-02-18), p. 142-
    Details
    In: Journal of Personalized Medicine, MDPI AG, Vol. 11, No. 2 ( 2021-02-18), p. 142-
    Abstract: Genomic structural variants comprise a significant fraction of somatic mutations driving cancer onset and progression. However, such variants are not readily revealed by standard next-generation sequencing. Optical genome mapping (OGM) surpasses short-read sequencing in detecting large ( 〉 500 bp) and complex structural variants (SVs) but requires isolation of ultra-high-molecular-weight DNA from the tissue of interest. We have successfully applied a protocol involving a paramagnetic nanobind disc to a wide range of solid tumors. Using as little as 6.5 mg of input tumor tissue, we show successful extraction of high-molecular-weight genomic DNA that provides a high genomic map rate and effective coverage by optical mapping. We demonstrate the system’s utility in identifying somatic SVs affecting functional and cancer-related genes for each sample. Duplicate/triplicate analysis of select samples shows intra-sample reliability but also intra-sample heterogeneity. We also demonstrate that simply filtering SVs based on a GRCh38 human control database provides high positive and negative predictive values for true somatic variants. Our results indicate that the solid tissue DNA extraction protocol, OGM and SV analysis can be applied to a wide variety of solid tumors to capture SVs across the entire genome with functional importance in cancer prognosis and treatment.
    Type of Medium: Online Resource
    ISSN: 2075-4426
    URL: Article
    DOI: 10.3390/jpm11020142
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2662248-8
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  • 5
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    Laceration of Aberrant Internal Carotid Artery Following Myringotomy: A Case Report and Review of Literature
    SAGE Publications ; 2022
    In:  Annals of Otology, Rhinology & Laryngology Vol. 131, No. 5 ( 2022-05), p. 555-561
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 131, No. 5 ( 2022-05), p. 555-561
    Abstract: The presence of an aberrant internal carotid artery (ICA) in the middle ear is rare. Patients may be asymptomatic or complain of conductive hearing loss, otalgia, pulsatile tinnitus, or aural fullness. Otoscopic exam findings can include a pulsating erythematous lesion on the tympanic membrane (TM). It may be misdiagnosed as a glomus tumor, hemangioma, or serous otitis media, or go unrecognized until surgical exploration. Early recognition is important as intraoperative discovery carries risk of iatrogenic injury, hemorrhage and subsequent neurologic sequelae. Prevention requires adequate preoperative suspicion and can be confirmed with radiologic examination via computed tomography (CT) scan or magnetic resonance angiography (MRA). Management of iatrogenic injury of an aberrant ICA can include packing, vessel embolization and/or surgical ligation. Patient case: We report the case of an aberrant ICA injury in a pediatric patient undergoing a myringotomy with tube placement, who sustained neurologic deficits that eventually resolved following treatment with packing and coil embolization. Discussion and conclusions: An aberrant ICA can cause life-threatening complications without prior diagnosis in a routine myringotomy. Suspicious exam findings should prompt temporal bone CT to rule out aberrant ICA or other vascular pathology of the middle ear prior to surgery. In the case of iatrogenic injury of an aberrant ICA, there is no consensus in existing literature on optimal management. We reviewed 37 studies to compare therapeutic options and subsequent outcomes. Though complications are rare regardless of management, cases in which solely packing was utilized demonstrated an increased incidence of hemiparesis, aphasia, hearing loss, re-bleeding, and delayed pseudoaneurysm, as compared to an approach coupling packing with embolization or ligation, both of which have comparable outcomes.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/00034894211028468
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2033055-8
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  • 6
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    Long Term Olfactory Outcomes Following Frontal Sinus Surgery in Chronic Rhinosinusitis
    Wiley ; 2021
    In:  The Laryngoscope Vol. 131, No. 10 ( 2021-10), p. 2173-2178
    Details
    In: The Laryngoscope, Wiley, Vol. 131, No. 10 ( 2021-10), p. 2173-2178
    Abstract: No studies have evaluated the impact of the types of frontal sinus surgery (FSS) on objective olfaction scores. This study evaluated olfactory function and quality of life (QOL) in chronic rhinosinusitis (CRS) patients before and after total ethmoidectomy with frontal sinusotomy (FS). Study Design Prospective cohort study. Methods A prospective study of adult CRS patients undergoing FSS (Draf 2 or Draf 3 procedures) was conducted at a tertiary care center. Primary outcomes included brief smell identification test (BSIT) and sinonasal outcome test‐22 (SNOT‐22), which were assessed during preoperative evaluation, 6 to 9 weeks postoperatively, and 12 to 24 weeks postoperatively. Normosmia was defined as BSIT ≥9. Statistical significance was determined using the Wilcoxon signed‐rank test with α  = .05. Results Thirty‐eight patients followed up 12 to 24 weeks after FSS. The differences between baseline and long‐term outcomes for BSIT (6.11 vs. 8.24, P  = .00034) and SNOT‐22 (55.49 vs. 24.32, P   〈  .00001) scores were found to be statistically significant. Although both subgroups had clinically significant olfactory improvements, only the Draf 2 cohort experienced a statistically significant improvement in olfaction at long‐term follow‐up. There was no statistically significant change in data from 6 to 9 weeks to 12 to 24 weeks postoperatively. Conclusions Patients undergoing total ethmoidectomy with FS demonstrated statistically significant increases in olfaction and QOL at long‐term postoperative follow‐up. This study demonstrated that FS does not negatively impact the olfactory improvement seen in sinus surgery. The lack of statistically significant changes in these olfactory metrics from short to long‐term follow‐up suggests that there is no additional negative effect of FSS in the long term. Level of Evidence 3 Laryngoscope , 131:2173–2178, 2021
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    URL: Article
    DOI: 10.1002/lary.v131.10
    DOI: 10.1002/lary.29513
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2026089-1
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  • 7
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    The impact of surgeon volume on total thyroidectomy outcomes among otolaryngologists
    Elsevier BV ; 2020
    In:  American Journal of Otolaryngology Vol. 41, No. 6 ( 2020-11), p. 102726-
    Details
    In: American Journal of Otolaryngology, Elsevier BV, Vol. 41, No. 6 ( 2020-11), p. 102726-
    Type of Medium: Online Resource
    ISSN: 0196-0709
    URL: Article
    DOI: 10.1016/j.amjoto.2020.102726
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2041649-0
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  • 8
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    Virtual Reality as Distraction Analgesia for Office‐Based Procedures: A Randomized Crossover‐Controlled Trial
    Wiley ; 2021
    In:  Otolaryngology–Head and Neck Surgery Vol. 164, No. 3 ( 2021-03), p. 580-588
    Details
    In: Otolaryngology–Head and Neck Surgery, Wiley, Vol. 164, No. 3 ( 2021-03), p. 580-588
    Abstract: The purpose of this study was to explore the use of immersive and interactive virtual reality (VR) for analgesia, anxiety reduction, and overall satisfaction in patients undergoing outpatient postoperative debridements. Study Design Randomized crossover‐controlled trial. Setting Academic outpatient clinic. Subjects and Methods Adult patients who had functional endoscopic sinus surgery and skull base surgery and were undergoing office‐based postoperative nasal endoscopy and debridement were recruited and followed for 2 consecutive office visits. Participants were randomized to receive either the control or experimental analgesia for the first postoperative visit (PO1) and crossed over into the opposite treatment arm during the second postoperative visit (PO2). Outcomes included procedural pain, anxiety and satisfaction scores, procedural time, and reflexive head movements per minute (RHM). Results Eighty‐two participants were recruited. At PO1, 39 received standard analgesia, and 43 received an immersive VR experience. At PO1, the VR group experienced significantly less anxiety ( P =. 043) and fewer RHM ( P =. 00016) than the control group. At PO2, the VR group experienced significantly fewer RHM ( P =. 0002). At PO2, patients who received the experimental treatment after initially receiving the control treatment had significantly decreased pain, anxiety, and RHM. This effect was not seen in the second group. Overall, 69.51% of patients felt that the VR treatment was better; 19.51% thought that it was the same; and 9.76% found it to be worse. Conclusion VR technology holds promise as a nonpharmacologic analgesic and anxiolytic intervention for otolaryngology office‐based procedures. Further study of VR use in other procedures is warranted. Level of Evidence: 1, randomized controlled trial.
    Type of Medium: Online Resource
    ISSN: 0194-5998 , 1097-6817
    URL: Article
    DOI: 10.1177/0194599820942215
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2008453-5
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  • 9
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    Management of Jugular Bulb Stenosis in Pediatric Vein of Galen Malformation: A Novel Management Paradigm
    S. Karger AG ; 2021
    In:  Pediatric Neurosurgery Vol. 56, No. 6 ( 2021), p. 584-590
    Details
    In: Pediatric Neurosurgery, S. Karger AG, Vol. 56, No. 6 ( 2021), p. 584-590
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Pediatric vein of Galen malformations (VOGMs) are fistulous intracranial malformations arising congenitally within the choroidal fissure that can present with an array of neurological and cardiac sequelae. Associated venous stenosis may result in intracranial venous hypertension and ischemia leading to severe, irreversible cerebral injury. Management of neonatal VOGMs typically involves staged embolization and angioplasty/stenting for relief of venous stenosis. Rarely, jugular foraminal narrowing has been identified as causing jugular bulb stenosis. 〈 b 〉 〈 i 〉 Case Presentation: 〈 /i 〉 〈 /b 〉 We present the case of a 22-month-old female diagnosed with VOGM prenatally who displayed persistent intracranial venous hypertension despite multiple neuroembolization procedures during the neonatal period. Following initial reduction in arteriovenous shunting, she once again developed venous hypertension secondary to jugular bulb stenosis for which angioplasty was attempted. Failure of angioplasty to relieve the venous hypertension prompted skull base imaging, which revealed jugular foraminal ossification and stenosis. Microsurgical jugular foraminotomy followed by balloon angioplasty and stenting significantly reduced jugular pressure gradients. Restenosis requiring re-stenting developed postoperatively at 9 months, but the patient has remained stable with significant improvement in cortical venous congestion. 〈 b 〉 〈 i 〉 Discussion/Conclusion: 〈 /i 〉 〈 /b 〉 This case demonstrates the efficacy of microsurgical decompression of the jugular foramen and endovascular angioplasty/stenting as a novel treatment paradigm for the management of intracranial venous hypertension in the setting of VOGM.
    Type of Medium: Online Resource
    ISSN: 1016-2291 , 1423-0305
    URL: Article
    DOI: 10.1159/000517653
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 1483546-0
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