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  • 1
    Online Resource
    Online Resource
    Synergistic effects of methotrexate and piperine on human osteosarcoma cell lines – An in-vitro study
    ScopeMed ; 2022
    In:  National Journal of Physiology, Pharmacy and Pharmacology , No. 0 ( 2022), p. 1-
    Details
    In: National Journal of Physiology, Pharmacy and Pharmacology, ScopeMed, , No. 0 ( 2022), p. 1-
    Abstract: Background: Osteosarcoma is a malignant cancer that effect bone and metastasizing to many vital organs such as lungs. There are many available drugs to treat the disease including tamoxifen, methotrexate (MTX), and cisplatin which have their own side effects and hurdles to become drugs of choice for the disease. On the other hand, introduction of herbal drugs as chemotherapeutic agents opened up new arena to potentiate the existing treatment by exhibiting synergy. Piperine (PPN) is widely used drug as anti-cancer agent as well as it has anti-inflammatory, analgesic properties, and also used in the treatment of abdominal pains, tuberculosis, arthritis, and respiratory illness. Aims and Objective: Thus, this study was designed to investigate the synergistic inhibitory potential of PPN and MTX on the MG63 osteosarcoma cell lines in vitro. Materials and Methods: The cell lines were cultured on DMEM medium and investigated for cytotoxicity of the drugs using MTT assay at 540 nm in UV. Three groups of cell lines administered with PPN, MTX, and PPN+MTX (1:1) in various concentrations and IC50 values were calculated based on the % cell viability graphs. Results: Results showed that the IC50 of PPN was 38.65, MTX was 123.98, and PPN+MTX was 15.13 proving the significant synergistic cytotoxic effect of PPN and MTX in inhibiting the proliferation of MG63 cell lines. Conclusion: Further research needs to be conducted in this field to elucidate the synergistic pathways in which PPN has shown a better anti-osteosarcoma effect when combined with MTX.
    Type of Medium: Online Resource
    ISSN: 2320-4672
    URL: Journal
    URL: Article
    DOI: 10.5455/njppp.
    DOI: 10.5455/njppp.2023.13.09426202214092022
    Language: Unknown
    Publisher: ScopeMed
    Publication Date: 2022
    detail.hit.zdb_id: 2711226-3
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  • 2
    Online Resource
    Online Resource
    A Comparative Study On Viability Of Mcf-7 Human Breast Cancer Cell Lines Using Piperine And Tamoxifen – An In Vitro Study With A Novel Mishmash
    Oriental Scientific Publishing Company ; 2018
    In:  Biomedical and Pharmacology Journal Vol. 11, No. 4 ( 2018-12-28), p. 1955-1959
    Details
    In: Biomedical and Pharmacology Journal, Oriental Scientific Publishing Company, Vol. 11, No. 4 ( 2018-12-28), p. 1955-1959
    Abstract: This breast cancer is the one which is common in people across the country with mortality incidence ratio of 66 in rural and 8 in urban according to statistics in India. Breast cancer can be cured once it is diagnosed appropriately and when treatment is started at right time with right drug in proper dosage. But chemotherapy itself have many adverse events, to come over these problems, we can always have a help of natural products in hand like Piperine for the safety in future. To evaluate Anti-Cancer activity of Piperine and Tamoxifen and in both as Combination on the MCF 7 human breast cancer cell lines. Breast cancer cells (MCF) have been treated with piperine and incubated at 37 c, the drug samples are added and incubated for 3 hours then followed by MTT dye is added and incubated.1 ml of dimethyl sulfoxide is added and incubated. Absorbance at 537nm was measured with UV spectrophotometer using DMSO as the blank. Then IC50 was determined in graphical representation according to percentage of cell viability and concentration of sample. The anti-cancer effect of Piperine and Tamoxifen and in Combination, when treated with MCF 7 human breast cancer cell lines, starting from minimum to maximum dose concentration (μg/ml), the percentage of cell viability is 51.49 at the dose of 62.5 μg/ml, 51.09 at 125 μg/ml, 52 at the dose of 32.5 for Piperine, tamoxifen and combination respectively. From this study, the drug Piperine on combining with Tamoxifen have significant anti-cancer activity, which would probably play a role as cytotoxic agent in tumour cells.
    Type of Medium: Online Resource
    ISSN: 0974-6242 , 2456-2610
    URL: Issue
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.13005/bpj/11/
    DOI: 10.13005/bpj/11/04
    DOI: 10.13005/bpj
    DOI: 10.13005/bpj/1568
    Language: English
    Publisher: Oriental Scientific Publishing Company
    Publication Date: 2018
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  • 3
    Online Resource
    Online Resource
    Adverse Events Following Immunization to CovId-19 vaccines in A Tertiary Care Hospital – A descriptive Study
    Oriental Scientific Publishing Company ; 2021
    In:  Biomedical and Pharmacology Journal Vol. 14, No. 4 ( 2021-12-30), p. 2149-2156
    Details
    In: Biomedical and Pharmacology Journal, Oriental Scientific Publishing Company, Vol. 14, No. 4 ( 2021-12-30), p. 2149-2156
    Abstract: Introduction: The pandemic due to Coronavirus disease 2019 (COVID-19) is a major health issue resulting in mortality across the globe. Multiple newer medications are being tried in treatment but with minimal success. The development of vaccines is occurring with unprecedented speed using different platforms with collaborations of academia and the pharmaceutical industries globally. These vaccines are approved for emergency use authorization by health authorities based on limited data from clinical trials. Hence, there is a need for active surveillance of vaccine recipients to monitor for safety. Methods: Adverse drug reaction monitoring centre (AMC) of our institute is actively involved in surveillance of recipients for adverse events following immunization (AEFI) who received vaccines for COVID-19 from the vaccination centre of the institute. As per the guidelines of National Coordinating Centre (NCC), Pharmacovigilance Programme of India (PvPI), designated staff of AMC follows up vaccine recipients over their registered mobile number post-vaccination for AEFI if any. This is a descriptive study of all the AEFI reported to NCC, PvPI between 16th January 2021 and 31st March 2021. Results: Of the 5793 doses of vaccination administered during the study period, 59.4% (3443) responded to follow up and 8.6% (299 of 3443) recipients reported 509 AEFI. The most common reported AEFI include fever, generalized body pains, and headache constituting 36.1%, 30.5%, and 18.5% respectively. 64.2% (327 of 509) of AEFI were reported from people younger than 45 years of age. Though females constituted 53.8% (161 of 299) of people who reported AEFI, total number of events reported from this group was 58% (295 of 509). More number of AEFI were observed after first dose of COVISHIELD compared to second dose. Conclusion: COVID-19 vaccination drive is rolled out in multiple phases for different age groups across the country. Many vaccinations are being approved for use in general public with limited data from clinical trials. Active surveillance of COVID-19 vaccines for AEFI helps us in further understanding safety issues beyond the clinical trial environment.
    Type of Medium: Online Resource
    ISSN: 2456-2610 , 0974-6242
    URL: Issue
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.13005/bpj/14
    DOI: 10.13005/bpj/14/04
    DOI: 10.13005/bpj
    DOI: 10.13005/bpj/2312
    Language: English
    Publisher: Oriental Scientific Publishing Company
    Publication Date: 2021
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  • 4
    Online Resource
    Online Resource
    Evaluation of Anticariogenic Efficacy of Pomegranate (Punica Granatum) Pericarp Extract as Natural Mouth Rinse: An In Vitro and In Vivo Study
    Oriental Scientific Publishing Company ; 2018
    In:  Biomedical and Pharmacology Journal Vol. 11, No. 4 ( 2018-12-28), p. 2025-2030
    Details
    In: Biomedical and Pharmacology Journal, Oriental Scientific Publishing Company, Vol. 11, No. 4 ( 2018-12-28), p. 2025-2030
    Abstract: Plant materials were known as source of new antimicrobial agents. Many efforts have been made to develop alternative mouth rinses from natural products which are safe, easily available and substitute the standard pharmaceutical remedies. Thus, considering the therapeutic value of pomegranate fruit, the present study was designed to compare the antimicrobial efficacy of aqueous extract of Pomegranate pericarp and commercially available Chlorhexidine mouth wash against caries causative microorganisms both in vitro and in vivo. To evaluate the antimicrobial efficacy of pomegranate pericarp extract (PPE) against Streptococcus mutans (S.mutans) and to determine its usefulness as anti caries mouth rinse. In vitro antimicrobial efficacy was evaluated by disc inhibition zone method and broth dilution assay considering minimum inhibitory concentration of PPE. In vivo evaluation was done as a randomised controlled trial which included thirty children aged between 6-12 years. They were divided randomly into 3 groups of ten each and subjected to different mouth rinses - Group I: PPE mouth rinse, Group II: 0.2% Chlorhexidine mouth rinse and Group III: Distilled water (control). The salivary samples which were collected before and after (5 minutes) mouth rinsing were inoculated on Mutans Sanguis agar and the bacterial count was calculated.Statistically significant decrease in salivary S.mutans count was observed in group I and II compared to group III after mouth rinsing. However, there was no statistically significant difference between groups I and II. PPE mouthwash was effective in reducing the salivary S.mutans count and was comparable to chlorhexidine mouth rinse. Hence PPE mouth rinse may be considered as a potential anti caries mouth rinse.
    Type of Medium: Online Resource
    ISSN: 0974-6242 , 2456-2610
    URL: Issue
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.13005/bpj/11/
    DOI: 10.13005/bpj/11/04
    DOI: 10.13005/bpj
    DOI: 10.13005/bpj/1578
    Language: English
    Publisher: Oriental Scientific Publishing Company
    Publication Date: 2018
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  • 5
    Online Resource
    Online Resource
    A study on concurring effect of paclitaxel and thymoquinone on MCF-7 cell line – In vitro
    ScopeMed ; 2023
    In:  National Journal of Physiology, Pharmacy and Pharmacology , No. 0 ( 2023), p. 1-
    Details
    In: National Journal of Physiology, Pharmacy and Pharmacology, ScopeMed, , No. 0 ( 2023), p. 1-
    Abstract: Background: Breast cancer is notorious for causing mortality and morbidity in most of the cancer patients which is spread to approximately 19.3 million people worldwide. Out of the various drugs available to treat breast cancers, thymoquinone (TMQ) and Paclitaxel (PCT) are known to have significant effects in varied mechanisms. However, only a limited literature is available to prove the activity when given as combined therapy. This opens a new arena for investigations to explore the efficacy of the combined drugs. As a result, a combination of these drugs may be a viable and risk-free treatment option for breast cancer. Aims and Objectives: The present research was designed to evaluate the individual anti-cancer effects of TMQ and PCT to their combined effects on MCF-7 breast cancer cell lines in an effort to enhance the disease’s therapeutic profile. Materials and Methods: Breast cancer (MCF-7) cell lines were cultured and incubated after exposure to the drugs in Dulbecco’s modified Eagle’s medium and MTT assay was conducted to determine the cell viability at 540 nm in UV spectroscopy. IC50 individual drugs treated groups TMQ and PCT and combined treatment group (TMQ + PCT) were determined using cell viability graph. Results: Results showed that the IC50 of TMQ was 31.2 μg/mL, PCT was 57.28 μg/ml, and TMQ + PCT were 4.20 μg/mL which proves the significant activity of the combined drug therapy using combination of TMQ and PCT on MCF-7 cell lines. Conclusion: This work enables researchers to investigate the potential for synergism between several anticancer medications to establish effective choices for the treatment of breast cancer with a fewer side effects.
    Type of Medium: Online Resource
    ISSN: 2320-4672
    URL: Journal
    URL: Article
    DOI: 10.5455/njppp.
    DOI: 10.5455/njppp.2023.13.09428202319092023
    Language: Unknown
    Publisher: ScopeMed
    Publication Date: 2023
    detail.hit.zdb_id: 2711226-3
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