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  • 1
    In: Audiology and Neurotology, S. Karger AG, Vol. 26, No. 6 ( 2021), p. 414-424
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Cochlear implantation is a recent approach proposed to treat single-sided deafness (SSD) and asymmetric hearing loss (AHL). Several cohort studies showed its effectiveness on tinnitus and variable results on binaural hearing. The main objective of this study is to assess the outcomes of cochlear implantation and other treatment options in SSD/AHL on quality of life. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 This prospective multicenter study was conducted in 7 tertiary university hospitals and included an observational cohort study of SSD/AHL adult patients treated using contralateral routing of the signal (CROS) hearing aids or bone-anchored hearing systems (BAHSs) or who declined all treatments, and a randomized controlled trial in subjects treated by cochlear implantation, after failure of CROS and BAHS trials. In total, 155 subjects with SSD or AHL, with or without associated tinnitus, were enrolled. After 2 consecutive trials with CROS hearing aids and BAHSs on headband, all subjects chose any of the 4 treatment options (abstention, CROS, BAHS, or cochlear implant [CI]). The subjects who opted for a CI were randomized between 2 arms (CI vs. initial observation). Six months after the treatment choice, quality of life was assessed using both generic (EuroQoL-5D, EQ-5D) and auditory-specific quality-of-life indices (Nijmegen Cochlear implant Questionnaire [NCIQ] and Visual Analogue Scale [VAS] for tinnitus severity). Performances for speech-in-noise recognition and localization were measured as secondary outcomes. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 CROS was chosen by 75 subjects, while 51 opted for cochlear implantation, 18 for BAHSs, and 11 for abstention. Six months after treatment, both EQ-5D VAS and auditory-specific quality-of-life indices were significantly better in the “CI” arm versus “observation” arm. The mean effect of the CI was particularly significant in subjects with associated severe tinnitus (mean improvement of 20.7 points ± 19.7 on EQ-5D VAS, 20.4 ± 12.4 on NCIQ, and 51.4 ± 35.4 on tinnitus). No significant effect of the CI was found on binaural hearing results. Before/after comparisons showed that the CROS and BAHS also improved significantly NCIQ scores (for CROS: +7.7, 95% confidence interval [95% CI] = [4.5; 10.8] ; for the BAHS: +14.3, 95% CI = [7.9; 20.7]). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Cochlear implantation leads to significant improvements in quality of life in SSD and AHL patients, particularly in subjects with associated severe tinnitus, who are thereby the best candidates to an extension of CI indications.
    Type of Medium: Online Resource
    ISSN: 1420-3030 , 1421-9700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 1481979-X
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  • 2
    In: Clinical Otolaryngology, Wiley, Vol. 46, No. 4 ( 2021-07), p. 736-743
    Abstract: To describe the treatment choice in a cohort of subjects with single‐sided deafness (SSD) and asymmetric hearing loss (AHL). To assess the reliability of the treatment trials. Design In this national, multicentre, prospective study, the choice of subjects was made after two consecutive trials of Contralateral Routing Of the Signal (CROS) hearing aids and a Bone Conduction Device (BCD) on a headband. Subjects could proceed with one of these two options, opt for cochlear implantation or decline all treatments. Setting Seven tertiary university hospitals. Participants One hundred fifty‐five subjects with SSD or AHL fulfilling the candidacy criteria for cochlear implantation, with or without associated tinnitus. Main outcome measures After the two trials, the number of subjects choosing each option was described. Repeated assessments of both generic and auditory‐specific quality of life were conducted, as well as hearing assessments (speech recognition in noise and horizontal localization). Results CROS was chosen by 75 subjects, followed by cochlear implantation (n = 51), BCD (n = 18) and abstention (n = 11). Patients who opted for cochlear implantation had a poorer quality of life ( P  = .03). The improvement of quality of life indices after each trial was significantly associated with the final treatment choice ( P  = .008 for generic indices, P  = .002 for auditory‐specific indices). The follow‐up showed that this improvement had been overestimated in the CROS group, with a long‐term retention rate of 52.5%. Conclusions More than one third of SSD/AHL subjects are unsatisfied after CROS and BCD trials. Repeated quality of life assessments help counselling the patient for his/her treatment choice.
    Type of Medium: Online Resource
    ISSN: 1749-4478 , 1749-4486
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2206071-6
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  • 3
    In: L’Année psychologique, CAIRN, Vol. 112, No. 01 ( 2012-3), p. 17-48
    Type of Medium: Online Resource
    ISSN: 0003-5033 , 1955-2580
    RVK:
    Language: English
    Publisher: CAIRN
    Publication Date: 2012
    detail.hit.zdb_id: 2274519-1
    SSG: 5,2
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  • 4
    Online Resource
    Online Resource
    Journal of Neurosurgery Publishing Group (JNSPG) ; 2000
    In:  Journal of Neurosurgery Vol. 92, No. 5 ( 2000-05), p. 890-
    In: Journal of Neurosurgery, Journal of Neurosurgery Publishing Group (JNSPG), Vol. 92, No. 5 ( 2000-05), p. 890-
    Type of Medium: Online Resource
    ISSN: 0022-3085
    RVK:
    RVK:
    Language: Unknown
    Publisher: Journal of Neurosurgery Publishing Group (JNSPG)
    Publication Date: 2000
    detail.hit.zdb_id: 2026156-1
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  • 5
    Online Resource
    Online Resource
    Society for Neuroscience ; 2009
    In:  The Journal of Neuroscience Vol. 29, No. 21 ( 2009-05-27), p. 7065-7078
    In: The Journal of Neuroscience, Society for Neuroscience, Vol. 29, No. 21 ( 2009-05-27), p. 7065-7078
    Abstract: Misalignment of interaural cortical response maps in asymmetric hearing loss evolves from initial gross divergence to near convergence over a 6 month recovery period. The evolution of left primary auditory cortex (AI) interaural frequency map changes is chronicled in squirrel monkeys with asymmetric hearing loss induced by overstimulating the right ear with a 1 kHz tone at 136 dB for 3 h. AI frequency response areas (FRAs), derived from tone bursts presented to the poorer or better hearing ears, are compared at 6, 12, and 24 weeks after acoustic overstimulation. Characteristic frequency (CF) and minimum threshold parameters are extracted from FRAs, and they are used to quantify interaural response map differences. A large interaural CF map misalignment of ΔCF ∼1.27 octaves at 6 weeks after overstimulation decreases substantially to ΔCF ∼0.62 octave at 24 weeks. Interaural cortical threshold map misalignment faithfully reflects peripheral asymmetric hearing loss at 6 and 12 weeks. However, AI threshold map misalignment essentially disappears at 24 weeks, primarily because ipsilateral cortical thresholds have become unexpectedly elevated relative to peripheral thresholds. The findings document that plastic change in central processing of sound stimuli arriving from the nominally better hearing ear may account for progressive realignment of both interaural frequency and threshold maps.
    Type of Medium: Online Resource
    ISSN: 0270-6474 , 1529-2401
    Language: English
    Publisher: Society for Neuroscience
    Publication Date: 2009
    detail.hit.zdb_id: 1475274-8
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    American Physiological Society ; 2005
    In:  Journal of Neurophysiology Vol. 94, No. 2 ( 2005-08), p. 1299-1311
    In: Journal of Neurophysiology, American Physiological Society, Vol. 94, No. 2 ( 2005-08), p. 1299-1311
    Abstract: The squirrel monkey twitter call is an exemplar of a broad class of species-specific vocalizations that contain naturally voiced frequency-modulated (FM) sweeps. To investigate how this prominent communication call element is represented in primary auditory cortex (AI), neuronal receptive field properties to pure-tone and synthetic, logarithmically spaced FM-sweep stimuli in 3 barbiturate-anesthetized squirrel monkeys are studied. Responses to pure tones are assessed by using standard measures of frequency response areas, whereas responses to FM sweeps are classified according to direction selectivity, best speed, and speed tuning preferences. Most neuronal clusters respond to FM sweeps in both directions and over a range of FM speeds. Center frequencies calculated from the average of high and low trigger frequency edges of FM response profiles are highly correlated with pure-tone characteristic frequencies (CFs). However, bandwidth estimates are only weakly correlated with their pure-tone counterparts. CF and direction selectivity are negatively correlated. Best speed maps reveal idiosyncratically positioned spatial aggregation of similar values. In contrast, direction selectivity maps show unambiguous spatial organization. Neuronal clusters selective for upward-directed FM sweeps are located in ventral–caudal AI, where CFs range from 0.5 to 1 kHz. Combinations of pure-tone and FM response parameters form 2 significant factors to account for response variations. These results are interpreted in the context of earlier FM investigations and neuronal encoding of dynamic sounds.
    Type of Medium: Online Resource
    ISSN: 0022-3077 , 1522-1598
    RVK:
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2005
    detail.hit.zdb_id: 80161-6
    detail.hit.zdb_id: 1467889-5
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  • 7
    Online Resource
    Online Resource
    American Physiological Society ; 2004
    In:  Journal of Neurophysiology Vol. 91, No. 2 ( 2004-02), p. 841-854
    In: Journal of Neurophysiology, American Physiological Society, Vol. 91, No. 2 ( 2004-02), p. 841-854
    Abstract: The current study was conducted to extend our understanding of changes in spatial organization and response properties of cortical neurons in the developing mammalian forebrain. Extracellular multiunit responses to tones were recorded from a dense array of penetrations covering entire isofrequency contours in the primary auditory cortex (AI) of pentobarbital anesthetized kittens. Ages ranged from postnatal day 14 (P14), shortly after acquisition of normal auditory response thresholds, through postnatal day 111 (P111), when the kittens were largely mature. Spatial organization of the AI was tonotopically ordered by P14. The tonotopic gradient decreased with chronological maturation. At P14 the gradient was about 3.5 kHz/mm. By P111 it had declined to about 2.5 kHz/mm, so that the cortical region encompassing a fixed 3- to 15-kHz frequency range enlarged along its posterior-anterior dimension. Response properties of developing AI neurons changed in both frequency selectivity and intensity selectivity. The mean frequency tuning bandwidth increased with age. Initially, tuning bandwidths were narrow throughout the entire AI. With progressive maturation, broader bandwidths were observed in areas dorsal and ventral to a central region in which neurons remained narrowly tuned. The resulting spatial organization of tuning bandwidth was similar to that reported in adult cats. The majority of recording sites manifested nonmonotonic rate/level functions at all ages. However, the proportion of sites with monotonic rate/level functions increased with age. No spatial organization of rate/level functions (monotonic and nonmonotonic) was observed through P111. The relatively late development of bandwidth tuning in the AI compared with the early presence of tonotopic organization suggests that different developmental processes are responsible for structuring these two dimensions of acoustic selectivity.
    Type of Medium: Online Resource
    ISSN: 0022-3077 , 1522-1598
    RVK:
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2004
    detail.hit.zdb_id: 80161-6
    detail.hit.zdb_id: 1467889-5
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  • 8
    In: Audiology and Neurotology, S. Karger AG, Vol. 14, No. 2 ( 2009), p. 106-114
    Abstract: 〈 i 〉 Objective: 〈 /i 〉 To evaluate speech performance, in quiet and noise, and localization ability in adult patients who had undergone bilateral and simultaneous implantation. 〈 i 〉 Study Design: 〈 /i 〉 Prospective multi-center study. 〈 i 〉 Methods: 〈 /i 〉 Twenty-seven adult patients with profound or total hearing loss were bilaterally implanted in a single-stage procedure, and simultaneously activated (Med-El, Combi 40/40+). Subjects were assessed before implantation and at 3, 6 and 12 months after switch-on. Speech perception tests in monaural and binaural conditions were performed in quiet and in noise using disyllabic words, with speech coming from the front and a cocktail party background noise coming from 5 loudspeakers. Sound localization measurements were also performed in background noise coming from 5 loudspeakers positioned from –90° to +90° azimuth in the horizontal plane, and using a speech stimulus. 〈 i 〉 Results: 〈 /i 〉 There was a bilateral advantage at 12 months in quiet (77 ± 5.0% in bilateral condition, 67 ± 5.3% for the better ear, p 〈 0.005) and in noise (signal-to-noise ratio +15 dB: 63 ± 5.9% in bilateral condition, 55 ± 6.9% for the better ear, p 〈 0.05). Considering unilateral speech scores recorded in quiet at 12 months, subjects were categorized as ‘good performers’ (speech comprehension score ≥60% for the better ear, n = 19) and ‘poor performers’ (n = 8). Subjects were also categorized as ‘asymmetrical’ (difference between their 2 unilateral speech scores ≥20%, n = 11) or ‘symmetrical’ (n = 16). The largest advantage (bilateral compared to the better ear) was obtained in poor performers: +19% compared to +7% in good performers (p 〈 0.05). In the group of good performers, there was a bilateral advantage only in cases of symmetrical results between the 2 ears (n = 10). In the group of poor performers, the bilateral advantage was shown in both patients with symmetrical (n = 6) and asymmetrical results (n = 2). In bilateral conditions, the sound localization ability in noise was improved compared to monaural conditions in patients with symmetrical and asymmetrical performance between the 2 ears. No preoperative factor (age, duration of deafness, use of hearing aids, etiology, etc.) could predict the asymmetrical performance, nor which ear would be the best. 〈 i 〉 Conclusion: 〈 /i 〉 This study demonstrates a bilateral advantage (at 12 months after the implantation) in speech intelligibility and sound localization in a complex noisy environment. In quiet, this bilateral advantage is shown in cases of poor performance of both ears, and in cases of good performance with symmetrical results between the 2 ears. No preoperative factor can predict the best candidates for a simultaneous bilateral implantation.
    Type of Medium: Online Resource
    ISSN: 1420-3030 , 1421-9700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
    detail.hit.zdb_id: 1481979-X
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  • 9
    In: Clinical Otolaryngology, Wiley, Vol. 43, No. 6 ( 2018-12), p. 1478-1486
    Abstract: The aim of this study was to compare quality of life ( QOL ) in small unilateral vestibular schwannoma ( VS ) patients managed by microsurgery, radiotherapy or observation. Study design A retrospective chart review. Methods The study included a total of 142 patients with VS stage 1 or 2 according to the Koos classification and treated between January 2004 and December 2015. Microsurgery, radiotherapy and observation groups comprised 43, 46 and 53 patients, respectively. All patients completed four QOL (questionnaires: Short‐Form Health Survey 36, Hearing Handicap Inventory, Tinnitus Handicap Inventory and Dizziness Handicap Inventory Short‐Form). Clinical symptoms and QOL were compared among groups. Results The average time interval between management and filling in the questionnaires was 66 months. There was no difference in QOL between the three groups on any of the four questionnaires. The most debilitating symptom was vertigo for all three groups. Tinnitus was a pejorative factor in the surgery group. Hearing level was deteriorated after microsurgery but there was no significant difference between the radiotherapy group and the middle fossa approach. Conclusion Patients with small VS stage 1 and 2 had similar QOL , irrespective of management by observation, radiotherapy or microsurgery. The overall predictor for long‐term reduced QOL was vertigo. Vestibular rehabilitation could improve QOL in symptomatic patients.
    Type of Medium: Online Resource
    ISSN: 1749-4478 , 1749-4486
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2206071-6
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  • 10
    Online Resource
    Online Resource
    Wiley ; 2020
    In:  Clinical Otolaryngology Vol. 45, No. 5 ( 2020-09), p. 762-767
    In: Clinical Otolaryngology, Wiley, Vol. 45, No. 5 ( 2020-09), p. 762-767
    Abstract: The objective of this study was to compare the tumour control and facial nerve outcome according to the therapeutic strategy, that is extent of resection and post‐operative radiotherapy. Design Retrospective study of patients with a giant vestibular schwannoma surgically treated from 4 academic skull base centres. Setting Extent of resection, neurological complications, facial nerve function, MRI follow‐up and occurrence of complementary treatment were reviewed. Participants Sixty patients were included from 2000 to 2018. Main outcome measures Primary end points were comparison the tumour control rate and the post‐operative House‐Brackmann grade at last follow‐up according to the extent of tumour removal ( ie total or subtotal removal). Secondary end points were assessment risk factors of poor facial nerve function and comparison complication rate according to extent of tumour removal. Results Sixty patients had initial surgery at diagnosis. A total resection was realised in 21 cases and a subtotal resection in 39 cases. Thirteen patients needed further treatment. One patient had a recurrence and needed a second surgery 108 months after the initial total resection surgery. Twelve patients underwent post‐operative radiotherapy, for an evolutive residual tumour. Tumour control was more successful in the total resection group (log‐rank test, P  = .015). There was no tumour recurrence after post‐operative radiotherapy. The facial nerve outcome was significantly better in the subtotal resection group (Mean House‐Brackmann grade at last follow‐up: 2.2 ± 1.9) than in the total resection group (House‐Brackmann grade: 3.5 ± 2.2) ( P  = .033). Vestibular schwannoma with a cystic component had better facial nerve outcome ( P  = .0082). Other than facial paralysis, neurological complications were observed in six patients (10% of patients): lower cranial nerves dysfunction in five cases and hemiparesis in one case. Conclusions Subtotal resection of giant vestibular schwannomas leads to favourable tumour control and facial nerve function and therefore seems to be a valuable strategy.
    Type of Medium: Online Resource
    ISSN: 1749-4478 , 1749-4486
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2206071-6
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