In:
Neonatology, S. Karger AG, Vol. 53, No. 6 ( 1988), p. 321-326
Abstract:
Decrease in serum calcium level leading to hypocalcemia during the first week of life is a frequent finding in premature neonates. Eight premature neonates presenting with such an episode of hypocalcemia in the course of their first 4 days of life were studied. They were fed with a phosphate-enriched human milk and given vitamin D 〈 sub 〉 3 〈 /sub 〉 (2,100 IU/day per os). We have evaluated the effect of a 24-hour pharmacologic calcium infusion on the circulating levels of calcium, inorganic phosphate, magnesium, 25-hydroxycalciferol (25-OHD), 1α,25-dihydroxycalciferol [1,25(OH) 〈 sub 〉 2 〈 /sub 〉 D] and immunoreactive parathyroid hormone (iPTH). After the infusion, circulating iPTH and P 〈 sub 〉 i 〈 /sub 〉 levels dropped significantly (p 〈 0.025 and p 〈 0.005 respectively) whereas serum Ca and 25-OHD (p 〈 0.005) increased. Mg and 1,25(OH) 〈 sub 〉 2 〈 /sub 〉 D serum levels remained unchanged. Our data show that an increased calcium supply sustained for 24 h induces an appropriate response in iPTH secretion. Effects on circulating levels of 1,25(OH) 〈 sub 〉 2 〈 /sub 〉 D were variable and probably reflected individual differences in half life of 1,25(OH)2D or in set points in the feedback mechanisms involved in the control of 1,25(OH) 〈 sub 〉 2 〈 /sub 〉 D synthesis.
Type of Medium:
Online Resource
ISSN:
1661-7800
,
1661-7819
Language:
English
Publisher:
S. Karger AG
Publication Date:
1988
detail.hit.zdb_id:
2403535-X
SSG:
12
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