In:
Journal of the American Veterinary Medical Association, American Veterinary Medical Association (AVMA), Vol. 226, No. 4 ( 2005-02-15), p. 556-561
Abstract:
Objective —To evaluate adrenal sex hormone concentrations
in response to ACTH stimulation in healthy dogs, dogs with adrenal tumors, and dogs with pituitary-
dependent hyperadrenocorticism (PDH). Design —Prospective study. Animals —11 healthy control dogs, 9 dogs with
adrenal-dependent hyperadrenocorticism (adenocarcinoma [ACA] or other tumor); 11 dogs with PDH, and 6 dogs with noncortisol-secreting adrenal tumors
(ATs). Procedure —Hyperadrenocorticism was diagnosed on
the basis of clinical signs; physical examination findings; and results of ACTH stimulation test, low-dose
dexamethasone suppression test, or both. Dogs with noncortisol-secreting ATs did not have hyperadrenocorticism
but had ultrasonographic evidence of an AT. Concentrations of cortisol, androstenedione, estradiol,
progesterone, testosterone, and 17-hydroxyprogesterone were measured before and 1 hour after IM
administration of 0.25 mg of synthetic ACTH. Results —All dogs with ACA, 10 dogs with PDH, and
4 dogs with ATs had 1 or more sex hormone concentrations greater than the reference range after ACTH
stimulation. The absolute difference for progesterone, 17-hydroxyprogesterone, and testosterone concentrations
(value obtained after ACTH administration minus value obtained before ACTH administration) was significantly
greater for dogs with ACA, compared with the other 3 groups. The absolute difference for
androstenedione was significantly greater for dogs with ACA, compared with dogs with AT and healthy
control dogs. Conclusions and Clinical Relevance —Dogs with
ACA secrete increased concentrations of adrenal sex hormones, compared with dogs with PDH, noncortisol-secreting ATs, and healthy dogs. Dogs with noncortisol-secreting ATs also have increased concentrations of sex hormones. There is great interdog variability
in sex hormone concentrations in dogs with ACA after stimulation with ACTH. ( J Am Vet Med Assoc 2005;226:556–561)
Type of Medium:
Online Resource
ISSN:
0003-1488
DOI:
10.2460/javma.2005.226.556
Language:
Unknown
Publisher:
American Veterinary Medical Association (AVMA)
Publication Date:
2005
detail.hit.zdb_id:
2904887-4
SSG:
22
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