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  • 1
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    Online Resource
    Outcome of neoadjuvant treatment for pancreatic cancer in elderly patients: comparative, observational cohort study
    Oxford University Press (OUP) ; 2021
    In:  British Journal of Surgery Vol. 108, No. 8 ( 2021-08-19), p. 976-982
    Details
    In: British Journal of Surgery, Oxford University Press (OUP), Vol. 108, No. 8 ( 2021-08-19), p. 976-982
    Abstract: Use of neoadjuvant therapy for elderly patients with pancreatic cancer has been debatable. With FOLFIRINOX (folinic acid, 5-fluorouracil, irinotecan, oxaliplatin) or gemcitabine plus nab-paclitaxel (GnP) showing tremendous effects in improving the overall survival of patients with borderline resectable and locally advanced pancreatic cancer, there is no definitive consensus regarding the use of this regimen in the elderly. Methods This study evaluated the eligibility of elderly patients with borderline resectable or locally advanced pancreatic cancer for neoadjuvant therapy. Patients registered in the database of pancreatic cancer at the University of Colorado Cancer Center, who underwent neoadjuvant treatment between January 2011 and March 2019, were separated into three age groups (less than 70, 70–74, 75 or more years) and respective treatment outcomes were compared. Results The study included 246 patients with pancreatic cancer who underwent neoadjuvant treatment, of whom 154 and 71 received chemotherapy with FOLFIRINOX and GnP respectively. Among these 225 patients, 155 were younger than 70 years, 36 were aged 70–74 years, and 34 were aged 75 years or older. Patients under 70 years old received FOLFIRINOX most frequently (124 of 155 versus 18 of 36 aged 70–74 years, and 12 of 34 aged 75 years or more; P  & lt; 0.001). Resectability was similar among the three groups (60.0, 58.3, and 55.9 per cent respectively; P = 0.919). Trends towards shorter survival were observed in the elderly (median overall survival time 23.6, 18.0, and 17.6 months for patients aged less than 70, 70–74, and 75 or more years respectively; P = 0.090). After adjusting for co-variables, age was not a significant predictive factor. Conclusion The safety and efficacy of multiagent chemotherapy in patients aged 75 years or over were similar to those in younger patients. Modern multiagent regimens could be a safe and viable treatment option for clinically fit patients aged at least 75 years.
    Type of Medium: Online Resource
    ISSN: 0007-1323 , 1365-2168
    URL: Article
    DOI: 10.1093/bjs/znab092
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2006309-X
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  • 2
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    Operational forecasts of the geomagnetic Dst index : OPERATIONAL FORECASTS OF THE GEOMAGNETIC DST INDEX
    American Geophysical Union (AGU) ; 2002
    In:  Geophysical Research Letters Vol. 29, No. 24 ( 2002-12), p. 34-1-34-4
    Details
    In: Geophysical Research Letters, American Geophysical Union (AGU), Vol. 29, No. 24 ( 2002-12), p. 34-1-34-4
    Type of Medium: Online Resource
    ISSN: 0094-8276
    URL: Article
    DOI: 10.1029/2002GL016151
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2002
    detail.hit.zdb_id: 2021599-X
    detail.hit.zdb_id: 7403-2
    SSG: 16,13
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  • 3
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    GNSS Radio Occultation Data in the AWS Cloud
    American Geophysical Union (AGU) ; 2024
    In:  Earth and Space Science Vol. 11, No. 2 ( 2024-02)
    Details
    In: Earth and Space Science, American Geophysical Union (AGU), Vol. 11, No. 2 ( 2024-02)
    Abstract: A repository of all historical Earth Radio occultation (RO) data of the atmosphere is now freely accessible in the Amazon Web Services Registry of Open Data Data are organized to enable common RO, atmospheric science, and climate science research by users anywhere RO sounding data are easily queried, subset, and downloaded through a Python package available by PyPI
    Type of Medium: Online Resource
    ISSN: 2333-5084 , 2333-5084
    URL: Article
    DOI: 10.1029/2023EA003021
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2024
    detail.hit.zdb_id: 2807271-6
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  • 4
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    Cannabis use and post-operative complications in patients undergoing pancreatic resection
    Elsevier BV ; 2021
    In:  HPB Vol. 23 ( 2021), p. S556-S557
    Details
    In: HPB, Elsevier BV, Vol. 23 ( 2021), p. S556-S557
    Type of Medium: Online Resource
    ISSN: 1365-182X
    URL: Article
    DOI: 10.1016/j.hpb.2021.06.200
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2071267-4
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  • 5
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    Benchmarks in pancreatic surgery. A novel tool for unbiased outcome comparisons
    Elsevier BV ; 2020
    In:  HPB Vol. 22 ( 2020), p. S383-
    Details
    In: HPB, Elsevier BV, Vol. 22 ( 2020), p. S383-
    Type of Medium: Online Resource
    ISSN: 1365-182X
    URL: Article
    DOI: 10.1016/j.hpb.2020.04.431
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2071267-4
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  • 6
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    The colour of the dark side of the Moon
    EDP Sciences ; 2014
    In:  Astronomy & Astrophysics Vol. 563 ( 2014-3), p. A38-
    Details
    In: Astronomy & Astrophysics, EDP Sciences, Vol. 563 ( 2014-3), p. A38-
    Type of Medium: Online Resource
    ISSN: 0004-6361 , 1432-0746
    URL: Article
    DOI: 10.1051/0004-6361/201322776
    RVK:
    UA 1000
    RVK:
    US 1090
    Language: English
    Publisher: EDP Sciences
    Publication Date: 2014
    detail.hit.zdb_id: 1458466-9
    SSG: 16,12
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  • 7
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    Ring current influence on auroral electrojet predictions
    Copernicus GmbH ; 1999
    In:  Annales Geophysicae Vol. 17, No. 10 ( 1999-10-31), p. 1268-1275
    Details
    In: Annales Geophysicae, Copernicus GmbH, Vol. 17, No. 10 ( 1999-10-31), p. 1268-1275
    Abstract: Abstract. Geomagnetic storms and substorms develop under strong control of the solar wind. This is demonstrated by the fact that the geomagnetic activity indices Dst and AE can be predicted from the solar wind alone. A consequence of the strong control by a common source is that substorm and storm indices tend to be highly correlated. However, a part of this correlation is likely to be an effect of internal magnetospheric processes, such as a ring-current modulation of the solar wind-AE relation. The present work extends previous studies of nonlinear AE predictions from the solar wind. It is examined whether the AE predictions are modulated by the Dst index.This is accomplished by comparing neural network predictions from Dst and the solar wind, with predictions from the solar wind alone. Two conclusions are reached: (1) with an optimal set of solar-wind data available, the AE predictions are not markedly improved by the Dst input, but (2) the AE predictions are improved by Dst if less than, or other than, the optimum solar-wind data are available to the net. It appears that the solar wind-AE relation described by an optimized neural net is not significantly modified by the magnetosphere's Dst state. When the solar wind alone is used to predict AE, the correlation between predicted and observed AE is 0.86, while the prediction residual is nearly uncorrelated to Dst. Further, the finding that Dst can partly compensate for missing information on the solar wind, is of potential importance in operational forecasting where gaps in the stream of real time solar-wind data are a common occurrence.Key words. Magnetospheric physics (solar wind · magnetosphere interactions; storms and substorms)
    Type of Medium: Online Resource
    ISSN: 1432-0576
    URL: Article
    DOI: 10.1007/s00585-999-1268-x
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 1999
    detail.hit.zdb_id: 1458425-6
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  • 8
    Online Resource
    Online Resource
    Predicting geomagnetic storms from solar-wind data using time-delay neural networks
    Copernicus GmbH ; 1996
    In:  Annales Geophysicae Vol. 14, No. 7 ( 1996-07-31), p. 679-686
    Details
    In: Annales Geophysicae, Copernicus GmbH, Vol. 14, No. 7 ( 1996-07-31), p. 679-686
    Abstract: Abstract. We have used time-delay feed-forward neural networks to compute the geomagnetic-activity index Dst one hour ahead from a temporal sequence of solar-wind data. The input data include solar-wind density n, velocity V and the southward component Bz of the interplanetary magnetic field. Dst is not included in the input data. The networks implement an explicit functional relationship between the solar wind and the geomagnetic disturbance, including both direct and time-delayed non-linear relations. In this study we especially consider the influence of varying the temporal size of the input-data sequence. The networks are trained on data covering 6600 h, and tested on data covering 2100 h. It is found that the initial and main phases of geomagnetic storms are well predicted, almost independent of the length of the input-data sequence. However, to predict the recovery phase, we have to use up to 20 h of solar-wind input data. The recovery phase is mainly governed by the ring-current loss processes, and is very much dependent on the ring-current history, and thus also the solar-wind history. With due consideration of the time history when optimizing the networks, we can reproduce 84% of the Dst variance.
    Type of Medium: Online Resource
    ISSN: 1432-0576
    URL: Article
    DOI: 10.1007/s00585-996-0679-1
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 1996
    detail.hit.zdb_id: 1458425-6
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  • 9
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    Comparing neoadjuvant chemotherapy with or without radiation therapy for pancreatic ductal adenocarcinoma: National Cancer Database cohort analysis
    Oxford University Press (OUP) ; 2022
    In:  British Journal of Surgery Vol. 109, No. 5 ( 2022-04-19), p. 450-454
    Details
    In: British Journal of Surgery, Oxford University Press (OUP), Vol. 109, No. 5 ( 2022-04-19), p. 450-454
    Abstract: Neoadjuvant treatment is important for improving the rate of R0 surgical resection and overall survival outcome in treating patients with pancreatic ductal adenocarcinoma (PDAC). However, the true efficacy of radiotherapy (RT) for neoadjuvant treatment of PDAC is uncertain. This retrospective study evaluated the treatment outcome of neoadjuvant RT in the treatment of PDAC. Methods Collected from the National Cancer Database, information on patients with PDAC who underwent neoadjuvant chemotherapy (NAC) and pancreatectomy between 2010 to 2016 was used in this study. Short- and long-term outcomes were compared between patients who received neoadjuvant chemoradiotherapy (NACRT) and NAC. Results The study included 6936 patients, of whom 3185 received NACRT and 3751 NAC. The groups showed no difference in overall survival (NACRT 16.1 months versus NAC 17.4 months; P = 0.054). NACRT is associated with more frequent margin negative resection (86.1 versus 80.0 per cent; P & lt; 0.001) but a more unfavourable 90-day mortality than NAC (6.4 versus 3.6 per cent; P & lt; 0.001). The odds of 90-day mortality were higher in the radiotherapy group (odds ratio 1.81; P & lt; 0.001), even after adjusting for significant covariates. Patients who received NACRT received single-agent chemotherapy more often than those who received NAC (31.5 versus 10.7 per cent; P & lt; 0.001). Conclusion This study failed to show a survival benefit for NACRT over NAC alone, despite its association with negative margin resection. The significantly higher mortality in NACRT warrants further investigation into its efficacy in the treatment of pancreatic cancer.
    Type of Medium: Online Resource
    ISSN: 0007-1323 , 1365-2168
    URL: Article
    DOI: 10.1093/bjs/znac002
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
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  • 10
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    Online Resource
    Quantification of structural uncertainty in climate data records from GPS radio occultation
    Copernicus GmbH ; 2013
    In:  Atmospheric Chemistry and Physics Vol. 13, No. 3 ( 2013-02-06), p. 1469-1484
    Details
    In: Atmospheric Chemistry and Physics, Copernicus GmbH, Vol. 13, No. 3 ( 2013-02-06), p. 1469-1484
    Abstract: Abstract. Global Positioning System (GPS) radio occultation (RO) has provided continuous observations of the Earth's atmosphere since 2001 with global coverage, all-weather capability, and high accuracy and vertical resolution in the upper troposphere and lower stratosphere (UTLS). Precise time measurements enable long-term stability but careful processing is needed. Here we provide climate-oriented atmospheric scientists with multicenter-based results on the long-term stability of RO climatological fields for trend studies. We quantify the structural uncertainty of atmospheric trends estimated from the RO record, which arises from current processing schemes of six international RO processing centers, DMI Copenhagen, EUM Darmstadt, GFZ Potsdam, JPL Pasadena, UCAR Boulder, and WEGC Graz. Monthly-mean zonal-mean fields of bending angle, refractivity, dry pressure, dry geopotential height, and dry temperature from the CHAMP mission are compared for September 2001 to September 2008. We find that structural uncertainty is lowest in the tropics and mid-latitudes (50° S to 50° N) from 8 km to 25 km for all inspected RO variables. In this region, the structural uncertainty in trends over 7 yr is 〈0.03% for bending angle, refractivity, and pressure, 〈3 m for geopotential height of pressure levels, and 〈0.06 K for temperature; low enough for detecting a climate change signal within about a decade. Larger structural uncertainty above about 25 km and at high latitudes is attributable to differences in the processing schemes, which undergo continuous improvements. Though current use of RO for reliable climate trend assessment is bound to 50° S to 50° N, our results show that quality, consistency, and reproducibility are favorable in the UTLS for the establishment of a climate benchmark record.
    Type of Medium: Online Resource
    ISSN: 1680-7324
    URL: Article
    DOI: 10.5194/acp-13-1469-2013
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2013
    detail.hit.zdb_id: 2092549-9
    detail.hit.zdb_id: 2069847-1
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