In:
FEBS Letters, Wiley, Vol. 507, No. 1 ( 2001-10-19), p. 101-104
Abstract:
We found that sparse and confluent C6 glioma cells differ both in GM3 content, which increases with cell density, and in endothelin‐1 (ET‐1)‐induced phosphoinositide hydrolysis, which was markedly higher in the sparse cells than in the confluent. Also after manipulation of the cellular GM3 content through treatment with exogenous GM3 or with drugs known to affect GM3 metabolism, the ET‐1 effect was inversely related to GM3 cellular levels. Cell treatment with an anti‐GM3 mAb resulted in the enhancement of ET‐1‐induced phospholipase C activation and restored the capacity of GM3‐treated cells to respond to ET‐1. These findings suggest that the GM3 ganglioside represents a physiological modulator of ET‐1 signaling in glial cells.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(01)02966-0
Language:
English
Publisher:
Wiley
Publication Date:
2001
detail.hit.zdb_id:
1460391-3
SSG:
12
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