In:
Diabetes, American Diabetes Association, Vol. 38, No. 2 ( 1989-02-01), p. 225-230
Abstract:
An injection of streptozocin (STZ) was used to study diabetes-induced peripheral neuropathy inrats. In such rats the values of motor nerve conduction velocity and sensory nerve conduction velocity were decreased compared with the values obtained in nondiabetic controls from 3 wk after STZ injection onward. In recent years it has been extensively documented that peptides related to ACTHand MSH exert a neurotrophic effect on the nervous system that results in enhanced recovery of function after mechanical nerve damage. This article documents the beneficial effect of the peptide Org 2766, an ACTH-(4–9) analogue, in diabetic peripheral neuropathy. Chronic subcutaneous treatmentof diabetic rats with Org 2766 results in a significant enhancement of both motor and sensory nerve conduction velocity compared with saline-treated diabetic rats. Histological analysis of cross sections of the sural nerve showed no difference in the total number of nerve fibers in saline- or peptide-treated diabetic rats. In contrast, a difference in fiber size distribution was demonstrated; i.e., the sural nerves of diabetic rats contained fewer thick myelinated fibers. Treatment with Org 2766 resulted in a normal distribution. Apparently, the peptide Org 2766 has a protective action on nerve fibers and nerve function during STZ-induced diabetes.
Type of Medium:
Online Resource
ISSN:
0012-1797
,
1939-327X
DOI:
10.2337/diab.38.2.225
Language:
English
Publisher:
American Diabetes Association
Publication Date:
1989
detail.hit.zdb_id:
1501252-9
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