In:
European Journal of Neurology, Wiley, Vol. 1, No. 2 ( 1994-11), p. 127-133
Abstract:
Among patients who underwent cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) examination during a 5‐year period, we found 18 patients at the multiple sclerosis center of the University of Rome and clinically definite multiple sclerosis, MRI white matter abnormalities, normal CSF examination, a disease duration of at least 1 year and an upper age of 〈 45 years at onset These patients were examined again with a variety of tests screening for different diseases mimicking multiple sclerosis. Alternative diagnoses reached after laboratory tests were: Lyme disease, two cases of vasculitis, mitochondrial encephalomyopathy, multiple ischemic lesions caused by atrial septum aneurysm and olivopontocerebellar atrophy. Hence, six of these 18 patients had a final diagnosis other than multiple sclerosis, while 12 remained with a final diagnosis of “MS with normal CSF”. Our study suggests that in patients with a clinical picture of multiple sclerosis and disseminated white matter MRI lesions but no CSF abnormalities, the classical clinical criteria may not be sufficiently specific, unless confirmed by a very prolonged clinical history with repeated MRI.
Type of Medium:
Online Resource
ISSN:
1351-5101
,
1468-1331
DOI:
10.1111/ene.1994.1.issue-2
DOI:
10.1111/j.1468-1331.1994.tb00060.x
Language:
English
Publisher:
Wiley
Publication Date:
1994
detail.hit.zdb_id:
2020241-6
detail.hit.zdb_id:
1280785-0
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