In:
European Journal of Cardio-Thoracic Surgery, Oxford University Press (OUP)
Abstract:
To compare the outcomes of lung transplantations using grafts from donors aged over 70 years against those performed using younger donors. Material and Methods This retrospective single-center analysis includes lung transplants conducted at our institution from January 2014 to June 2022. Lung recipients were classified into two groups based on donor age (Group A & lt; 70 yo; group B ≥ 70 yo). Variables regarding demographics, peri, and postoperative outcomes, and survival were included. The statistical analysis approach included univariable analysis, propensity-score matching to address imbalances in donor variables (smoking status), recipient characteristics (sex, age, diagnosis and LAS) and calendar period, and survival analysis. RESULTS 353 lung transplants were performed in this period, 47 (13.3%) using grafts from donors aged over 70 years. Donors in group B were more frequently women (70.2% vs 51.6%, p = 0.017), with less smoking history (22% vs 43%, p = 0.002) and longer mechanical ventilation time (3 vs 2 days, p = 0.025). Recipients in group B had a higher LAS score (37.5 vs 35, p = 0.035). Postoperative variables were comparable between both groups, except for pulmonary function tests. Group B demonstrated lower FEV1 levels (2,070 mL vs 2,580 mL, p = 0.001). The propensity-score matching showed a lower chance of chronic lung allograft dysfunction by 12% for group B. 1-,3- and 5-year survival was equal between the groups. CONCLUSIONS The use of selected expanded-criteria donors aged over 70 years did not result in increased post-operative morbidity, early mortality, or survival in this study.
Type of Medium:
Online Resource
ISSN:
1873-734X
DOI:
10.1093/ejcts/ezae077
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2024
detail.hit.zdb_id:
1500330-9
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