GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Cisplatinum Induced Lesion of Proximal Tubule Acidification in the Rat
    S. Karger AG ; 1992
    In:  Kidney and Blood Pressure Research Vol. 15, No. 2 ( 1992), p. 106-112
    Details
    In: Kidney and Blood Pressure Research, S. Karger AG, Vol. 15, No. 2 ( 1992), p. 106-112
    Abstract: Rats were given a 4- to 6-mg/kg body weight intraperitoneal injection of the antitumor drug, Cisplatin, 5-7 days prior to experiments to study tubule acidification by clearance and stationary microperfusion techniques. Cisplatin reduced the glomerular filtration rate markedly and caused a moderate degree of metabolic acidosis, but urine acidification (pH) was well maintained. Proximal tubule stationary pH and bicarbonate concentrations, as measured by pH microelectrodes, were significantly increased. The defect of proximal H 〈 sup 〉 + 〈 /sup 〉 secretion is reflected by increased acidification half-times (from 4.44 to 10.2 s) and reduced bicarbonate reabsorption to 37% of control values. H-ion back flux, measured during tubule and capillary perfusions with Ringer’s bicarbonate- and CO 〈 sub 〉 2 〈 /sub 〉 -free phosphate solutions, was reduced to 68% of control values. The apparent H-ion permeability was lowered from 0.79 to 0.54 cm/s. These results indicate that proximal acidification is reduced by impairment of H 〈 sup 〉 + 〈 /sup 〉 transport and not by increased transepithelial H 〈 sup 〉 + 〈 /sup 〉 shunting. Blunted acidification is compatible with a reduction in the number of Na/H exchangers in the proximal brush border and/or a decrease in the apical sodium gradient, the driving force for proximal H-ion secretion. Cortical distal tubule acidification, measured by double-barreled ion-exchange resin/PD microelectrodes, was not significantly affected by Cisplatin. This accounts for the observation that, in spite of the impaired proximal acidification, urine pH is kept within the normal range.
    Type of Medium: Online Resource
    ISSN: 1420-4096 , 1423-0143
    URL: Article
    DOI: 10.1159/000173448
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1992
    detail.hit.zdb_id: 1482922-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Kinetics of potassium transport across single distal tubules of rat kidney
    Wiley ; 1973
    In:  The Journal of Physiology Vol. 232, No. 1 ( 1973-07-01), p. 47-70
    Details
    In: The Journal of Physiology, Wiley, Vol. 232, No. 1 ( 1973-07-01), p. 47-70
    Type of Medium: Online Resource
    ISSN: 0022-3751
    URL: Article
    DOI: 10.1113/jphysiol.1973.sp010256
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 1973
    detail.hit.zdb_id: 1475290-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Sodium Movement across Single Perfused Proximal Tubules of Rat Kidneys
    Rockefeller University Press ; 1964
    In:  The Journal of General Physiology Vol. 47, No. 6 ( 1964-07-01), p. 1175-1194
    Details
    In: The Journal of General Physiology, Rockefeller University Press, Vol. 47, No. 6 ( 1964-07-01), p. 1175-1194
    Abstract: Using perfusion techniques in single proximal tubule segments of rat kidney, the relationship between net sodium movement and active transport of ions, as measured by the short-circuit method, has been studied. In addition, the role of the colloid-osmotic pressure gradient in proximal transtubular fluid and sodium movement has been considered. Furthermore, the limiting concentration gradient against which sodium movement can occur and the relationship between intratubular sodium concentration and fluid transfer have been investigated. Comparison of the short-circuit current with the reabsorptive movement of sodium ions indicates that this process is largely, perhaps exclusively, active in nature. No measurable contribution of the normally existing colloid-osmotic pressure gradient to transtubular water movement was detected. On the other hand, fluid movement across the proximal tubular epithelium is dependent upon the transtubular sodium gradient and is abolished when a mean concentration difference of 50 mEq/liter is exceeded.
    Type of Medium: Online Resource
    ISSN: 1540-7748 , 0022-1295
    URL: Article
    DOI: 10.1085/jgp.47.6.1175
    Language: English
    Publisher: Rockefeller University Press
    Publication Date: 1964
    detail.hit.zdb_id: 1477246-2
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Micropuncture study of renal potassium excretion in the rat
    American Physiological Society ; 1964
    In:  American Journal of Physiology-Legacy Content Vol. 206, No. 4 ( 1964-04-01), p. 674-686
    Details
    In: American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 206, No. 4 ( 1964-04-01), p. 674-686
    Abstract: Samples of proximal and distal tubular fluid were collected from rats maintained on a control, a low-K, or a high-K, low-Na diet. All animals received inulin-C 14 . Plasma (P) and tubular fluid (TF) were analyzed for Na and K by dual-channel microflame photometry and assayed for radioactivity. Transtubular electrical potential differences were measured by means of glass microelectrodes. Mean TF/P ratios for potassium in the proximal tubule were slightly below unity in all groups of animals. A comparison of the relative increase in K and inulin-C 14 along the distal tubule indicates: 1) net movement of potassium into the tubular lumen in most control animals; 2) net movement of K into the tubular lumen of high-K, low-Na, sulfate-loaded animals, and in dichlorphenamide-treated animals on a control diet; and 3) the possibility of continued net reabsorption of potassium along the distal tubule and, particularly, the collecting duct in animals kept on a low-K diet. Distal tubular entry of potassium occurs down an electrochemical potential gradient.
    Type of Medium: Online Resource
    ISSN: 0002-9513
    URL: Article
    DOI: 10.1152/ajplegacy.1964.206.4.674
    RVK:
    WA 15000
    RVK:
    XA 20060
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1964
    detail.hit.zdb_id: 1477334-X
    detail.hit.zdb_id: 2065807-2
    detail.hit.zdb_id: 1477287-5
    detail.hit.zdb_id: 1477308-9
    detail.hit.zdb_id: 1477297-8
    detail.hit.zdb_id: 1477331-4
    detail.hit.zdb_id: 1477300-4
    detail.hit.zdb_id: 1477329-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Acidification in mammalian cortical distal tubule
    Elsevier BV ; 1994
    In:  Kidney International Vol. 45, No. 6 ( 1994-06), p. 1543-1554
    Details
    In: Kidney International, Elsevier BV, Vol. 45, No. 6 ( 1994-06), p. 1543-1554
    Type of Medium: Online Resource
    ISSN: 0085-2538
    URL: Article
    DOI: 10.1038/ki.1994.204
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1994
    detail.hit.zdb_id: 2007940-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Mechanism of renal hydrogen ion secretion
    Elsevier BV ; 1972
    In:  Kidney International Vol. 1, No. 5 ( 1972-05), p. 280-296
    Details
    In: Kidney International, Elsevier BV, Vol. 1, No. 5 ( 1972-05), p. 280-296
    Type of Medium: Online Resource
    ISSN: 0085-2538
    URL: Article
    DOI: 10.1038/ki.1972.41
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1972
    detail.hit.zdb_id: 2007940-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Intracellular Na concentration and Rb uptake in proximal convoluted tubule cells and abundance of Na/K-ATPase α1-subunit in NHE3−/− mice
    Springer Science and Business Media LLC ; 2003
    In:  Pflügers Archiv - European Journal of Physiology Vol. 446, No. 1 ( 2003-4), p. 100-105
    Details
    In: Pflügers Archiv - European Journal of Physiology, Springer Science and Business Media LLC, Vol. 446, No. 1 ( 2003-4), p. 100-105
    Type of Medium: Online Resource
    ISSN: 0031-6768 , 1432-2013
    URL: Article
    DOI: 10.1007/s00424-002-1001-z
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2003
    detail.hit.zdb_id: 1463014-X
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Quantitative Morphology of Renal Cortical Structures during Compensatory Hypertrophy
    S. Karger AG ; 1998
    In:  Nephron Experimental Nephrology Vol. 6, No. 4 ( 1998-7-15), p. 308-319
    Details
    In: Nephron Experimental Nephrology, S. Karger AG, Vol. 6, No. 4 ( 1998-7-15), p. 308-319
    Abstract: The compensatory hypertrophy in different renal cortical structures was studied in rats 10 and 21 days after unilateral nephrectomy (UNX). Quantitative morphological/stereological analysis revealed significant increases in total renal cortical volume – 33% on day 10 and 48% on day 21 – after UNX. These changes were paralleled by significant increments in the volumes of proximal convoluted tubule (PCT, 55%), distal convoluted tubule (DCT, 114%), and cortical collecting duct (CCD, 106%) segments on day 10. The corresponding changes on day 21 were 76, 122, and 212%, respectively. These alterations were accompanied by increases in segment length; 3% PCT, 23% DCT, and 50% CCD on day 10 and 9% PCT, 30% DCT, and 142% CCD on day 21 after UNX. The total luminal and basolateral cell membrane surface areas also exhibited a time-dependent increase after UNX. The increments in both luminal and basolateral membrane domains in PCT and DCT after 10 days were not significant, but reached significance after 21 days (PCT: luminal membrane 21%, basolateral membrane 63%; DCT: luminal membrane 98%, basolateral membrane 63%). In contrast, CCD membrane areas had increased substantially already 10 days after UNX (luminal membrane 92%, basolateral membrane 71%). It declined subsequently by day 21 (luminal membrane 57%, basolateral membrane 32%). The cell rubidium concentration after a 30-second rubidium infusion, an index of Na-K-ATPase activity, as well as sodium concentrations were unaltered in cells of all nephron segments investigated. Altogether the stereological analysis shows that the compensatory increase in organ volume can be attributed primarily to an increase in nephron epithelial volume. The PCT responds with ‘radial’ hypertrophy (thickening of the tubular epithelial wall), while the DCT undergoes ‘length’ hypertrophy (increase of tubular length without thickening of the tubular wall and without an increase in number of cells). This type of hypertrophy is especially prominent on day 21 after UNX for the CCD which doubles in length. Only on day 10 does the CCD seem to respond with hyperplasia. Adaptive changes in response to UNX develop gradually. Only a few of the morphological parameters studied had completed their change by 10 days, the majority required longer.
    Type of Medium: Online Resource
    ISSN: 1660-2129
    URL: Article
    DOI: 10.1159/000020538
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1998
    detail.hit.zdb_id: 2098337-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    THE EXTRARENAL RESPONSE TO ACUTE ACID-BASE DISTURBANCES OF RESPIRATORY ORIGIN 1
    American Society for Clinical Investigation ; 1955
    In:  Journal of Clinical Investigation Vol. 34, No. 2 ( 1955-02-1), p. 231-245
    Details
    In: Journal of Clinical Investigation, American Society for Clinical Investigation, Vol. 34, No. 2 ( 1955-02-1), p. 231-245
    Type of Medium: Online Resource
    ISSN: 0021-9738
    URL: Article
    DOI: 10.1172/JCI103076
    Language: English
    Publisher: American Society for Clinical Investigation
    Publication Date: 1955
    detail.hit.zdb_id: 2018375-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Living Renal Epithelial Cells Imaged by Atomic Force Microscopy
    S. Karger AG ; 1994
    In:  Nephron Vol. 66, No. 1 ( 1994), p. 8-13
    Details
    In: Nephron, S. Karger AG, Vol. 66, No. 1 ( 1994), p. 8-13
    Type of Medium: Online Resource
    ISSN: 1660-8151 , 2235-3186
    URL: Article
    DOI: 10.1159/000187759
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1994
    detail.hit.zdb_id: 2810853-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...