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  • 1
    Online Resource
    Online Resource
    Predictive factors for Alzheimer’s disease progression: a comprehensive retrospective analysis of 3,553 cases with 211 months follow-up
    Frontiers Media SA ; 2023
    In:  Frontiers in Neurology Vol. 14 ( 2023-8-24)
    Details
    In: Frontiers in Neurology, Frontiers Media SA, Vol. 14 ( 2023-8-24)
    Abstract: There is conflicting data regarding the predictors of Alzheimer’s Disease (AD), the most common form of dementia. The main objective of the study is to evaluate potential predictors of AD progression using a comprehensive follow-up dataset that includes functional/cognitive assessments, clinical and neuropsychiatric evaluations, and neuroimaging biomarkers such as hippocampal atrophy or white matter intensities (WMIs). Method A total of 161 AD cases were recruited from a dementia database consisting of individuals who consulted the Dementia Outpatient Clinic of the Neurology Department at Mersin University Medical Faculty between 2000 and 2022, under the supervision of the same senior author have at least 3 full evaluation follow-up visit including functional, clinical, biochemical, neuropsychological, and radiological screening. Data were exported and analyzed by experts accordingly. Results Mean follow-up duration of study sample was 71.66 ± 41.98, min 15 to max 211 months. The results showed a fast and slow progressive subgroup of our AD cases with a high sensitivity (Entropy = 0.836), with a close relationship with several cofactors and the level of disability upon admittance. Hippocampal atrophy and WMIs grading via Fazekas were found to be underestimated predictors of AD progression, and functional capacity upon admittance was also among the main stakeholders. Conclusion The study highlights the importance of evaluating multiple potential predictors for AD progression, including functional capacity upon admittance, hippocampal atrophy, and WMIs grading via Fazekas. Our findings provide insight into the complexity of AD progression and may contribute to the development of effective strategies for managing and treating AD.
    Type of Medium: Online Resource
    ISSN: 1664-2295
    URL: Article
    DOI: 10.3389/fneur.2023.1239995
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2564214-5
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  • 2
    Online Resource
    Online Resource
    Synthesis of flower-like MnO2 nanostructure with freshly prepared Cu particles and electrochemical performance in supercapacitors
    Public Library of Science (PLoS) ; 2022
    In:  PLOS ONE Vol. 17, No. 6 ( 2022-6-2), p. e0269086-
    Details
    In: PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 6 ( 2022-6-2), p. e0269086-
    Abstract: Four types of flowerlike manganese dioxide in nano scale was synthesized via a liquid phase method in KMnO 4 -H 2 SO 4 solution and Cu particles, wherein the effect of Cu particles was investigated in detail. The obtained manganese dioxide powder was characterized by XRD, SEM and TEM, and the supercapacity properties of MnO 2 electrode materials were measured. The results showed that doping carbon black can benefit to better dispersion of copper particles, resulting in generated smaller size of Cu particles, and the morphology of MnO 2 nanoparticles was dominated by that of Cu particles. The study of MnO 2 synthesis by different sources of Cu particles showed that the size of MnO 2 particles decreased significantly with freshly prepared fine copper powder compared with using commercial Cu powder, and the size of MnO 2 particles can be further reduced to 120 nm by prepared Cu particles with smaller size. Therefore, it was suggested that the copper particles served as not only the reductant and but also the nuclei centre for the growth of MnO 2 particles in synthesis process MnO 2 , and that is the reason how copper particles worked on the growth of flower-like MnO 2 and electrochemical property. In the part of investigation for electrochemical property, the calculated results of b values indicated that the electrode materials have pseudo capacitance property, and the highest specific capacitance of 197.2 F g -1 at 2 mV s -1 and 148 F/g at 1 A/g were obtained for MCE electrode materials (MnO 2 was synthesized with freshly prepared copper particles, where carbon black was used and dispersed in ethanol before preparation of Cu particles). The values of charge transfer resistance in all types of MnO 2 materials electrodes were smaller than 0.08 Ω. The cycling retention of MCE material electrode is still kept as 93.8% after 1000 cycles.
    Type of Medium: Online Resource
    ISSN: 1932-6203
    URL: Article
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    DOI: 10.1371/journal.pone.0269086
    DOI: 10.1371/journal.pone.0269086.g001
    DOI: 10.1371/journal.pone.0269086.g002
    DOI: 10.1371/journal.pone.0269086.g003
    DOI: 10.1371/journal.pone.0269086.g004
    DOI: 10.1371/journal.pone.0269086.g005
    DOI: 10.1371/journal.pone.0269086.g006
    DOI: 10.1371/journal.pone.0269086.g007
    DOI: 10.1371/journal.pone.0269086.g008
    DOI: 10.1371/journal.pone.0269086.t001
    DOI: 10.1371/journal.pone.0269086.t002
    DOI: 10.1371/journal.pone.0269086.s001
    Language: English
    Publisher: Public Library of Science (PLoS)
    Publication Date: 2022
    detail.hit.zdb_id: 2267670-3
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  • 3
    Online Resource
    Online Resource
    Alzheimer’s disease and Parkinson’s disease dementia: Practical tips for physicians
    AccScience Publishing ; 2023
    In:  Brain & Heart Vol. 2, No. 1 ( 2023-11-28), p. 1712-
    Details
    In: Brain & Heart, AccScience Publishing, Vol. 2, No. 1 ( 2023-11-28), p. 1712-
    Abstract: Dementia is a progressive disorder that weakens the intellectual abilities and causes the cognitive, behavioral, and functional decline in occupational and social areas. This research is targeted to extract a profile for the dementia diagnostic and clinical characteristics by evaluating the near-term effects of Alzheimer & rsquo;s disease (AD) and Parkinson & rsquo;s disease dementia (PD-D). A total of 240 individuals, including 60 AD patients, 60 PD-D patients, and 120 healthy controls, were included in the study. Data of individuals treated in a local dementia outpatient clinic between 2013 and 2023 were obtained from the clinic database. AD and PD-D diagnoses were made based on the revised National Institute on Aging and Alzheimer & rsquo;s Association (NIA-AA) criteria and movement disorder society (MDS) clinical diagnostic criteria, respectively. Functional, clinical, and neuropsychological evaluations of the patients were made by the same neurologist. Dementia staging and daily living activities were determined and categorized. In the patient group, functionality and instrumental activities of daily living (ADLs) scores were significantly worse than those of the control group, but there was no difference between the AD and PD-D groups. Calculation, verbal fluency, word list, early learning, and clock drawing test scores were lower in the AD group than in the PD-D group. Apathy, disinhibition, elution, irritability, abnormal motor movements, sleep, and appetite scores were significantly higher in the patient group than in the control group. While depression parameters were not significantly different between all the groups, hallucinations and anxiety parameters were significantly higher in the PD-D group than in the AD group. As an important predictor of independent living and the burden of disease, functional impairment is an important issue in patients with AD compared to those with PD-D. This study also highlights the neuropsychiatric perception disorder in terms of functional loss in AD and significant anxiety disorder for PD-D accompanied by early functional losses.
    Type of Medium: Online Resource
    ISSN: 2972-4139
    URL: Article
    DOI: 10.36922/bh.1712
    Language: Unknown
    Publisher: AccScience Publishing
    Publication Date: 2023
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