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  • 1
    Online Resource
    Online Resource
    Data_Sheet_1.pdf
    Frontiers Media SA ; 2022
    In:  Frontiers in Psychology Vol. 13 ( 2022-5-27)
    Details
    In: Frontiers in Psychology, Frontiers Media SA, Vol. 13 ( 2022-5-27)
    Abstract: Hypoxia can impair cognitive performance, whereas exercise can enhance it. The effects of hypoxia on cognitive performance during exercise appear to be moderated by exercise duration and intensity and by severity and duration of hypoxia and cognitive task. In normal individuals, exercise under hypoxia can evoke adverse post-exercise mood states, such as tension and fatigue. However, little is known about the effects of hypoxia during exercise in trained athletes. The purpose of this study was to investigate how hypoxia affected executive functions and mood states, assessed, respectively, during and post-exercise and to explore the role of motivation moderators, such as inhibition and activation systems (BIS-BAS). Two different sessions of exercise in normoxia and hypoxia (FiO2 13%), each lasting 18 min, were randomly assigned in a counterbalanced order and administered to seventeen male athletes. During exercise bouts, participants performed a mental task (BST) aimed to produce cognitive interference and suppression. Reaction times and accuracy of responses were recorded. After 5 min, all participants completed two questionnaires assessing mood states (ITAMS) and incidence of symptoms potentially related to hypoxia (AMS-C). The results show that hypoxia impairs cognitive performance in terms of slower reaction times, but a high BAS attenuates this effect. Participants with high BAS show an equivalent cognitive performance under hypoxia and normoxia conditions. No effects were found on mood states. Further research is required to investigate the role of BAS, cognitive abilities, and mood states in prolonged hypoxic conditions.
    Type of Medium: Online Resource
    ISSN: 1664-1078
    URL: Article
    URL: Article
    DOI: 10.3389/fpsyg.2022.906336
    DOI: 10.3389/fpsyg.2022.906336.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2563826-9
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  • 2
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    Energy Blockchain for Public Energy Communities
    MDPI AG ; 2021
    In:  Applied Sciences Vol. 11, No. 8 ( 2021-04-12), p. 3457-
    Details
    In: Applied Sciences, MDPI AG, Vol. 11, No. 8 ( 2021-04-12), p. 3457-
    Abstract: This paper suggests an application of blockchain as an energy open data ledger, designed to save and track data regarding the energy footprint of public buildings and public energy communities. The developed platform permits writing energy production and consumption of public buildings using blockchain-enabled smart meters. Once authenticated on the blockchain, this data can be made available to the public domain for techno-economic analyses for either research studies and internal or third parties audits, increasing, in this way, the perceived transparency of the public institutions. A further feature of the platform, starting on the previously disclosed raw data, allows calculating, validating, and sharing sustainability indicators of public buildings and facilities, allowing the tracking of their improvements in sustainability goals. The paper also provides the preliminary results of a field-test experimentation of the proposed platform on a group of public buildings, highlighting the possible benefits of its widespread exploitation.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    URL: Article
    DOI: 10.3390/app11083457
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2704225-X
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  • 3
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    Interstitial and Granulomatous Lung Disease in Inflammatory Bowel Disease Patients
    Oxford University Press (OUP) ; 2020
    In:  Journal of Crohn's and Colitis Vol. 14, No. 4 ( 2020-05-21), p. 480-489
    Details
    In: Journal of Crohn's and Colitis, Oxford University Press (OUP), Vol. 14, No. 4 ( 2020-05-21), p. 480-489
    Abstract: Interstitial lung [ILD] disease and granulomatous lung disease [GLD] are rare respiratory disorders that have been associated with inflammatory bowel disease [IBD]. Clinical presentation is polymorphic and aetiology is unclear. Methods This was an ECCO-CONFER project. Cases of concomitant ILD or GLD and IBD, or drug-induced ILD/GLD, were collected. The criteria for diagnosing ILD and GLD were based on definitions from the American Thoracic Society and the European Respiratory Society and on the discretion of reporting clinician. Results We identified 31 patients with ILD. The majority had ulcerative colitis [UC] [n = 22] . Drug-related ILD was found in 64% of these patients, 25 patients [80.6%] required hospitalisation, and one required non-invasive ventilation. The causative drug was stopped in all drug-related ILD, and 87% of patients received systemic steroids. At follow-up, 16% of patients had no respiratory symptoms, 16% had partial improvement, 55% had ongoing symptoms, and there were no data in 13%. One patient was referred for lung transplantation, and one death from lung fibrosis was reported. We also identified 22 GLD patients: most had Crohn’s disease [CD] [n = 17]. Drug-related GLD was found in 36% of patients and 10 patients [45.4%] required hospitalisation. The causative drug was stopped in all drug-related GLD, and 81% of patients received systemic steroids. Remission of both conditions was achieved in almost all patients. Conclusions ILD and GLD, although rare, can cause significant morbidity. In our series, over half of cases were drug-related and therefore focused pharmacovigilance is needed to identify and manage these cases.
    Type of Medium: Online Resource
    ISSN: 1873-9946 , 1876-4479
    URL: Article
    DOI: 10.1093/ecco-jcc/jjz165
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2389631-0
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  • 4
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    Tricarbonylchlororhenium(I) Carboxaldimine Derivatives: Synthesis, Structure, and NMR Characterization of Z and E Isomers
    Wiley ; 2006
    In:  European Journal of Inorganic Chemistry Vol. 2006, No. 14 ( 2006-07), p. 2885-2893
    Details
    In: European Journal of Inorganic Chemistry, Wiley, Vol. 2006, No. 14 ( 2006-07), p. 2885-2893
    Abstract: The ligand N ‐(2‐pyridylmethyl)anthracene‐9‐carboxaldimine ( 1 ) has been synthesized and characterized by NMR spectroscopic techniques. The experimental procedure leads selectively to the E isomer, which has been studied by a combined theoretical (Density Functional Theory) and 2D NOESY NMR spectroscopic approach. The trifluoroacetic acid promotes the E to Z isomerization of 1 . The process has been investigated by NMR spectroscopy and computationally for the neutral ligand 1 . DFT methods calculate that the E isomer is 2.2 kcal/mol more stable than the Z isomer, whereas the reverse situation is observed for the protonated species, where the Z isomer is 4.5 kcal/mol more stable than the E isomer. Transition state calculations for the interconversion of the neutral and protonated E species into their corresponding Z isomers show that the energy barriers are 27.6 and 20.3 kcal/mol for the neutral and protonated species, respectively. The reaction with pentacarbonylchlororhenium leads, in the absence and in the presence of trifluoroacetic acid, to the synthesis of the corresponding tricarbonylchlororhenium isomer complexes Re ‐ E ‐ 1 and Re ‐ Z ‐ 1 , respectively. Compounds Re ‐ E ‐ 1 and Re ‐ Z ‐ 1 were characterized by 1D and 2D NMR spectroscopy in solution, and their crystal structures were determined. Their photophysical and electrochemical properties are also reported. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
    Type of Medium: Online Resource
    ISSN: 1434-1948 , 1099-0682
    URL: Issue
    URL: Article
    DOI: 10.1002/ejic.v2006:14
    DOI: 10.1002/ejic.200600252
    RVK:
    VA 4072.5
    Language: English
    Publisher: Wiley
    Publication Date: 2006
    detail.hit.zdb_id: 1475009-0
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  • 5
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    Healthcare resource utilization and associated cost of patients with bone metastases from solid tumors who are naïve to bone-targeting agents: a comparative analysis of patients with and without skeletal-related events
    Springer Science and Business Media LLC ; 2021
    In:  The European Journal of Health Economics Vol. 22, No. 2 ( 2021-03), p. 243-254
    Details
    In: The European Journal of Health Economics, Springer Science and Business Media LLC, Vol. 22, No. 2 ( 2021-03), p. 243-254
    Abstract: This study analyzes the impact of skeletal-related events (SRE) on healthcare resource utilization (HCRU) and costs incurred by patients with bone metastases (BM) from solid tumors (ST), who are therapy-naïve to bone targeting agents (BTAs). Methods German claims data from 01/01/2010 to 30/06/2018 were used to conduct a retrospective comparative cohort analysis of BTA-naive patients with a BM diagnosis and preceding ST diagnosis. HCRU and treatment-related costs were compared in two matched cohorts of patients with and without a history of SREs, defined as pathological fracture, spinal cord compression, surgery to bone and radiation to bone. The first SRE was defined as the patient-individual index date. Conversely, for the non-SRE patients, index dates were assigned randomly. Results In total, 45.20% of 9,832 patients reported experiencing at least one SRE ( n  = 4444) while 54.80% experienced none ( n  = 5388); 2,434 pairs of SRE and non-SRE patients were finally matched (mean age: 70.87/71.07 years; females: 39.07%/38.58%). Between SRE and non-SRE cohorts, significant differences in the average number of hospitalization days per patient-year (35.80/30.80) and associated inpatient-care costs (14,199.27€/10,787.31€) were observed. The total cost ratio was 1.16 ( p   〈  0.001) with an average cost breakdown of 23,689.54€ and 20,403.27€ per patient-year in SRE and non-SRE patients. Conclusion The underutilization of BTAs within a clinical setting poses an ongoing challenge in the real-world treatment of BM patients throughout Germany. Ultimately, the economic burden of treating SREs in patients with BM from ST was found to be considerable, resulting in higher direct healthcare costs and increased utilization of inpatient care facilities.
    Type of Medium: Online Resource
    ISSN: 1618-7598 , 1618-7601
    URL: Article
    DOI: 10.1007/s10198-020-01247-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2011428-X
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  • 6
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    Diving response after a one-week diet and overnight fasting
    Informa UK Limited ; 2016
    In:  Journal of the International Society of Sports Nutrition Vol. 13, No. 1 ( 2016-01-05)
    Details
    In: Journal of the International Society of Sports Nutrition, Informa UK Limited, Vol. 13, No. 1 ( 2016-01-05)
    Type of Medium: Online Resource
    ISSN: 1550-2783
    URL: Article
    DOI: 10.1186/s12970-016-0134-y
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2162810-5
    detail.hit.zdb_id: 2508294-2
    SSG: 31
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  • 7
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    Photophysical properties and computational investigations of tricarbonylrhenium(I)[2-(4-methylpyridin-2-yl)benzo[d]-X-azole]L and tricarbonylrhenium(I)[2-(benzo[d]-X-azol-2-yl)-4-methylquinoline]L derivatives (X=N–CH3, O, or S; L=Cl−, pyridine)
    Elsevier BV ; 2007
    In:  Journal of Organometallic Chemistry Vol. 692, No. 6 ( 2007-2), p. 1377-1391
    Details
    In: Journal of Organometallic Chemistry, Elsevier BV, Vol. 692, No. 6 ( 2007-2), p. 1377-1391
    Type of Medium: Online Resource
    ISSN: 0022-328X
    URL: Article
    DOI: 10.1016/j.jorganchem.2006.11.004
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2007
    detail.hit.zdb_id: 1491530-3
    detail.hit.zdb_id: 3002-8
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  • 8
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    Burden of disease among patients with prevalent Crohn’s disease: results from a large German sickness fund
    Springer Science and Business Media LLC ; 2023
    In:  International Journal of Colorectal Disease Vol. 38, No. 1 ( 2023-03-20)
    Details
    In: International Journal of Colorectal Disease, Springer Science and Business Media LLC, Vol. 38, No. 1 ( 2023-03-20)
    Abstract: The aim of this study was to investigate the burden of disease among a real-world cohort of patients with prevalent Crohn’s disease (CD) in Germany. Methods We conducted a retrospective cohort analysis using administrative claims data from the German AOK PLUS health insurance fund. Continuously insured patients with a CD diagnosis between 01 October 2014 and 31 December 2018 were selected and followed for at least 12 months or longer until death or end of data availability on 31 December 2019. Medication use (biologics, immunosuppressants (IMS), steroids, 5-aminosalicylic acid) was assessed sequentially in the follow-up period. Among patients with no IMS or biologics (advanced therapy), we investigated indicators of active disease and corticosteroid use. Results Overall, 9284 prevalent CD patients were identified. Within the study period, 14.7% of CD patients were treated with biologics and 11.6% received IMS. Approximately 47% of all prevalent CD patients had mild disease, defined as no advanced therapy and signs of disease activity. Of 6836 (73.6%) patients who did not receive advanced therapy in the follow-up period, 36.3% showed signs of active disease; 40.1% used corticosteroids (including oral budesonide), with 9.9% exhibiting steroid dependency (≥ 1 prescription every 3 months for at least 12 months) in the available follow-up. Conclusions This study suggests that there remains a large burden of disease among patients who do not receive IMS or biologics in the real world in Germany. A revision of treatment algorithms of patients in this setting according to the latest guidelines may improve patient outcomes.
    Type of Medium: Online Resource
    ISSN: 1432-1262
    URL: Article
    DOI: 10.1007/s00384-023-04368-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1459217-4
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  • 9
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    Personalization of Context-Dependent Applications Through Trigger-Action Rules
    Association for Computing Machinery (ACM) ; 2017
    In:  ACM Transactions on Computer-Human Interaction Vol. 24, No. 2 ( 2017-04-30), p. 1-33
    Details
    In: ACM Transactions on Computer-Human Interaction, Association for Computing Machinery (ACM), Vol. 24, No. 2 ( 2017-04-30), p. 1-33
    Abstract: Our life is characterized by the presence of a multitude of interactive devices and smart objects exploited for disparate goals in different contexts of use. Thus, it is impossible for application developers to predict at design time the devices and objects users will exploit, how they will be arranged, and in which situations and for which objectives they will be used. For such reasons, it is important to make end users able to easily and autonomously personalize the behaviour of their Internet of Things applications, so that they can better comply with their specific expectations. In this paper, we present a method and a set of tools that allow end users without programming experience to customize the context-dependent behaviour of their Web applications through the specification of trigger-action rules. The environment is able to support end-user specification of more flexible behaviour than what can be done with existing commercial tools, and it also includes an underlying infrastructure able to detect the possible contextual changes in order to achieve the desired behaviour. The resulting set of tools is able to support the dynamic creation and execution of personalized application versions more suitable for users’ needs in specific contexts of use. Thus, it represents a contribution to obtaining low threshold/high ceiling environments. We also report on an example application in the home automation domain, and a user study that has provided useful positive feedback.
    Type of Medium: Online Resource
    ISSN: 1073-0516 , 1557-7325
    URL: Article
    DOI: 10.1145/3057861
    RVK:
    ST 640
    Language: English
    Publisher: Association for Computing Machinery (ACM)
    Publication Date: 2017
    detail.hit.zdb_id: 2006332-5
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  • 10
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    Methods and interpretation of comparative health insurance claims data studies: methodological foundations (Part 1)
    Springer Science and Business Media LLC ; 2022
    In:  Prävention und Gesundheitsförderung
    Details
    In: Prävention und Gesundheitsförderung, Springer Science and Business Media LLC
    Abstract: Comparative studies based on health insurance claims data can generate important evidence for the assessment of the effectiveness and safety of treatments in the real world; however, interpretation of study results is challenging due to methodological uncertainties associated with these studies. Objective The aim of this article is to describe important methodological elements of a comparative health insurance claims data study and, additionally, in a separate second manuscript, to demonstrate the impact of specific assumptions on the results of such a study in a case study. Materials and methods Based on research on existing guidelines regarding reporting and conducting comparative observational studies, we describe the main methodology options to conduct such studies. Results Generally, seven methodology dimensions characterize a comparative health insurance claims data study: (1) general study design, (2) identification of study population and comparator group, (3) definition of index date, (4) definition of observational period including censoring, (5) adjustment for differences in baseline characteristics, (6) selection of outcomes of interest, and (7) definition of measures for comparisons and outcomes analysis. Conclusion Publications dealing with comparative health insurance claims data should outline methodological assumptions in the described seven dimensions in a transparent way and, in addition, should provide reasons why specific methodological decisions were made.
    Type of Medium: Online Resource
    ISSN: 1861-6755 , 1861-6763
    URL: Article
    DOI: 10.1007/s11553-022-00979-5
    RVK:
    XF 1500
    Language: German
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2211781-7
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