In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 70, No. 8_Supplement ( 2010-04-15), p. 2714-2714
Abstract:
BACKGROUND: Colorectal cancer (CRC) is the third most common cancer, and survival in African Americans (AAs) is worse than Caucasians. Some studies suggest that the incidence of CRC is higher in AA patients below the age of 50 when compared to Caucasians. This study aims to confirm the higher prevalence of CRC in an AA population less than 50, and its implications to the screening guidelines. METHOD: In a retrospective study demographic data, indication and outcome of colonoscopy, and biopsy data were collected at Howard University Hospital (HUH) over a period of 21 years (1989-2008). All of the study patients were (AA), and cases were classified either symptomatic average risk (91%); or high risk (family history, IBD) (9%). Distribution of variables was studied by median (inter-quartile range) or number (%). RESULTS: Seventy five CRC cases younger than 50 years old were recorded from 1989 to 2008 at HUH. Median age (inter-quartile range) of these patients were 43 (40-46) years and 35 (47%) were female. Among them 55 (73%) were adenocarcinoma and 43 (57%) were located at left colon. In the same period a total of 671 CRC was recorded in HUH. We compared this data with 4591 CRC cases who were registered at District of Colombia (DC) from 1996 to 2007. While in HUH 11% of all CRC cases were under 50, this ratio for DC area was 9% (P=0.1). Among HUH patients 4%, 16% and 80% were 20-29, 30-39 and 40-49 years old, respectively. In DC area these ratios were 3%, 26% and 70% (P = 0.2). Among HUH tumors with available data 49%, 40%, 11% were local, regional, distant and unknown extension, while these proportions in DC area were 40%, 37%, 23% (P=0.018), respectively. CONCLUSION: Our data showed a high burden of colorectal CRC in young AAs ( & lt;50). CRC rate of 80% (60/75) was seen for the age group of 40-49, which indicates cancer in AAs may starts at younger age than predicted ( & lt;45). The American College of Gastroenterology recommends to start screening of AAs at age of 45, but this may not cover many high risk people who are younger than 45. Further study is needed on AAs to confirm these findings. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2714.
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.AM10-2714
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2010
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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