In:
British Journal of Haematology, Wiley, Vol. 144, No. 5 ( 2009-03), p. 726-731
Abstract:
Five cases of persistent polyclonal B‐cell lymphocytosis (PPBL) with progressive splenomegaly are reported; three were splenectomized. BCL2 / IGH rearrangements were found in three cases; HLA‐DRB1 *07 in all. Bone marrow (BM) trephines showed a moderate lymphoid infiltrate with intrasinusoidal distribution resembling a splenic marginal‐zone lymphoma. Splenic white pulp revealed an enlargement of the marginal‐zone area; red pulp was infiltrated by the same lymphocytes engulfing the sinuses. Splenic and BM B‐lymphocytes were CD79a + /CD20 + /IgM + /IgD + /bcl‐2 + /CD27 + /DBA.44 − /CD31 − and polyclonal by immunophenotype/polymerase chain reaction. PPBL features an expansion of splenic marginal‐zone B‐lymphocytes, which infiltrate BM sinusoids and circulate in the blood with no evidence of clonality, even in cases with progressive splenomegaly.
Type of Medium:
Online Resource
ISSN:
0007-1048
,
1365-2141
DOI:
10.1111/bjh.2009.144.issue-5
DOI:
10.1111/j.1365-2141.2008.07551.x
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
1475751-5
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