In:
Folia Medica, Pensoft Publishers, Vol. 64, No. 6 ( 2022-12-31), p. 975-981
Abstract:
Introduction : The ovariectomized rat is a model used to mimic the changes in female organism during menopause. Aronia melanocarpa fruit juice (AMFJ) is extremely rich in phenolic substances (procyanidins, flavonoids and phenolic acids). Aim : The present study aimed to evaluate the effects of AMFJ on rat behavior in a model of ovariectomy-induced estrogen deficit. Materials and methods : Four groups of female Wistar rats were used, each consisting of 14 animals – sham operated (SO), ovariectomized (OVX), OVX+AMFJ 5, and OVX+AMFJ 10 . After two-week recovery from the operation, three-month oral treatment was performed with distilled water for the SO and OVX groups, and AMFJ at doses of 5 ml/kg and 10 ml/kg for the OVX+AMFJ 5 and OVX+AMFJ 10 groups, respectively. Then, behavioral tests were conducted. Locomotor activity was assessed using the open field test (OFT). Anxiety was evaluated in the OFT, elevated plus-maze test and social interaction test. Depressive behavior was assessed in the forced swim test. Thermal pain sensitivity was measured in the hot plate test. Results : OVX rats showed increased anxiety, depressive behavior and pain sensitivity in comparison with SO animals. Compared to OVX rats, anxiety, depressive behavior, and pain sensitivity of AMFJ-treated animals were decreased. Locomotor activity of AMFJ-treated rats was reduced in comparison with both SO and OVX animals, probably due to the sedative effect of the juice. Conclusions : AMFJ was able to antagonize the negative impact of the estrogen deficit on rat behavior (anxiety, depression, pain sensitivity), probably due to the biological activity of its polyphenolic ingredients.
Type of Medium:
Online Resource
ISSN:
1314-2143
,
0204-8043
DOI:
10.3897/folmed.64.e68824
DOI:
10.3897/folmed.64.e68824.figure1
DOI:
10.3897/folmed.64.e68824.figure2
Language:
Unknown
Publisher:
Pensoft Publishers
Publication Date:
2022
detail.hit.zdb_id:
2593223-8
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