In:
Gynecology Obstetrics & Reproductive Medicine, Mebas Medikal Basin Yayin Ltd. Sti, Vol. 22, No. 1 ( 2016-04-29), p. 22-26
Abstract:
Objectives: To evaluate the impact of the uterine artery Doppler values and the change of β-Human chorionic gonadotropin (β-HCG) levels from day 0 to day 4 for prediction of the success of single dose methotrexate treatment in tubal pregnancy cases. Study Design: 50 patients with tubal pregnancy were included the prospective study. The location and size of ectopic pregnancy, bilateral uterine artery pulsed color doppler imaging was examined by ultrasonography and serum β-HCG levels were measured on day 0, 4, 7 of treatment. Success was defined as decrease of β-HCG level 〈 10 mIU/mL with single dose methotrexate treatment. Multiple dose methotrexate treatment and surgical treatment were considered as treatment failure.Results: 32 patients (64%) treated with single dose methotrexate, 14 patients (28%) treated with multiple dose methotrexate, and 4 patients (8%) treated with surgery. In the group with β-HCG level decrease 〉 15.04% on day 4, single-dose methotrexate therapy were 3.82 times more successful than the group without 〉 15.04% β-HCG decrease. However, no significant alteration of uterine artery Doppler measurements was determined on the same days.Conclusion: Reduction rate in the β-HCG level on day 4 of treatment can be used in determination the success of single-dose methotrexate therapy.
Type of Medium:
Online Resource
ISSN:
2602-4918
,
1300-4751
DOI:
10.21613/GORM.2016.90
Language:
Unknown
Publisher:
Mebas Medikal Basin Yayin Ltd. Sti
Publication Date:
2016
detail.hit.zdb_id:
2956437-2
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