In:
Angewandte Chemie International Edition, Wiley, Vol. 53, No. 25 ( 2014-06-16), p. 6358-6363
Abstract:
A combination of ab initio calculations, circular dichroism, nuclear magnetic resonance, and X‐ray photoelectron spectroscopy has shown that aluminum ions can induce the formation of backbone ring structures in a wide range of peptides, including neurodegenerative disease related motifs. These ring structures greatly destabilize the protein and result in irreversible denaturation. This behavior benefits from the ability of aluminum ions to form chemical bonds simultaneously with the amide nitrogen and carbonyl oxygen atoms on the peptide backbone.
Type of Medium:
Online Resource
ISSN:
1433-7851
,
1521-3773
DOI:
10.1002/anie.201307955
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2011836-3
detail.hit.zdb_id:
123227-7
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