In:
International Journal of Medicinal Chemistry, Hindawi Limited, Vol. 2012 ( 2012-05-02), p. 1-6
Abstract:
A novel series of N -(3-(6-substituted-aminopyridin-3-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides targeting TrkA receptor tyrosine kinase was identified. SAR study of the series allowed us to design and synthesize compounds possessing inhibitory activity of TrkA kinase enzyme in the low nanomolar range with low residual activity against c-Met and with no significant activity against VEGFR2.
Type of Medium:
Online Resource
ISSN:
2090-2069
,
2090-2077
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2012
detail.hit.zdb_id:
2582356-5
SSG:
15,3
Permalink