In:
FEBS Letters, Wiley, Vol. 506, No. 1 ( 2001-09-28), p. 45-50
Abstract:
Efficiency of Fas‐mediated apoptosis of lymphoid cells is regulated, among other means, by a mechanism involving its association with ezrin, a cytoskeletal protein belonging to the 4.1 family of proteins. In the present work, we provide evidence for a further molecule that associates to ezrin in Fas‐triggered apoptosis, the disialoganglioside GD3. In fact, as an early event, GD3 redistributed in membrane‐associated domains in uropods and co‐localized with ezrin. Co‐immunoprecipitation analyses confirmed this result, indicating a GD3–ezrin association. Altogether, these results are suggestive for a role of GD3 in Fas/ezrin‐mediated apoptosis, supporting the view that uropods contain a multimolecular signaling complex involved in Fas‐mediated apoptosis.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(01)02776-4
Language:
English
Publisher:
Wiley
Publication Date:
2001
detail.hit.zdb_id:
212746-5
detail.hit.zdb_id:
1460391-3
SSG:
12
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