In:
Crimea Journal of Experimental and Clinical Medicine, RIOR Publishing Center, Vol. 11, No. 1 ( 2022), p. 16-24
Abstract:
In the last 10 years, there has been an active study of the system of coupling the metabolism of a macroorgan- ism and its microbiome. The microbiotic conversion of food substrates into small biologically active signaling mol- ecules represents a potential regulatory mechanism by which the gut microbiota can alter the physiology of gut cells and the entire macroorganism. It was found that in patients with obesity, but without metabolic disorders, the level of serum tryptamine was statistically significantly higher than in patients with metabolically unhealthy obesity. For obesity, regardless of the presence/absence of metabolic disorders, it was found that xanthurenic and quinolic acids stimulate the secretion of myostatin. At the same time, for patients with metabolically healthy obesity, the leading role of indole-3-acetate in the coordinated stimulation of insulin and leptin secretion is shown. Whereas in patients with metabolically unhealthy obesity, anthranilic acid stimulates leptin secretion. For insulin, the decrease in secretion is provided by indole-3-propionate in patients with metabolically unhealthy obesity. In addition, indole-3-propionate and tryptamine activate the secretion of FGF 21 in patients with metabolically unhealthy obesity. From the data obtained, it can be assumed that changes in the concentrations of various tryptophan metabolites have a relationship with the level of adipokine/myokine secretion and, consequently, with the development of metabolically healthy or metabolically unhealthy obesity.
Type of Medium:
Online Resource
ISSN:
2224-6452
,
2224-6444
Uniform Title:
МЕТАБОЛИТЫ ТРИПТОФАНА – МЕДИАТОРЫ ОСИ «МИКРОБИОМ КИШЕЧНИКА – ЖИРОВАЯ ТКАНЬ»
DOI:
10.37279/2224-6444-2021-11-1
DOI:
10.37279/2224-6444-2021-11-1-16-24
Language:
Russian
Publisher:
RIOR Publishing Center
Publication Date:
2022
Permalink