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  • 1
    Online Resource
    Online Resource
    Neoadjuvant PD-1 inhibitor (Sintilimab) in NSCLC
    Elsevier BV ; 2020
    In:  Journal of Thoracic Oncology Vol. 15, No. 5 ( 2020-05), p. 816-826
    Details
    In: Journal of Thoracic Oncology, Elsevier BV, Vol. 15, No. 5 ( 2020-05), p. 816-826
    Type of Medium: Online Resource
    ISSN: 1556-0864
    URL: Article
    DOI: 10.1016/j.jtho.2020.01.017
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2223437-8
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  • 2
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    Efficacy and safety of neoadjuvant PD-1 blockade with sintilimab in resectable squamous non-small cell lung cancer (sqNSCLC).
    American Society of Clinical Oncology (ASCO) ; 2019
    In:  Journal of Clinical Oncology Vol. 37, No. 15_suppl ( 2019-05-20), p. 8531-8531
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 37, No. 15_suppl ( 2019-05-20), p. 8531-8531
    Abstract: 8531 Background: NSCLC patients who have potentially resectable disease often subsequently relapse after surgery. New therapy that prevents relapse after surgery is desperately needed. In this study, we tested the efficacy and safety of neoadjuvant sintilimab, an anti-PD-1 antibody, for patients with resectable sqNSCLC in China. Methods: All patients had treatment-naïve resectable sqNSCLC (stage IB-IIIA) that was confirmed by histopathology. Patients received two cycles of sintilimab (200 mg IV) on Day 1 and 22. Surgery was performed between Day 29-43. An enhanced PET/CT was obtained at baseline and seven days prior to surgery. Preliminary analysis of safety profile and efficacy was planned after at least 20 patients had received operation. Results: As of Jan. 28, 2019, 22 patients (20 males and 2 females) with sqNSCLC received two doses of sintilimab followed by radical resection. The median age was 61.5 yr (range, 48 to 70). Six (27.3%) and four (18.2%) patients experienced neoadjuvant treatment emergent adverse events (TEAEs) and neoadjuvant treatment-related AEs (TRAEs), respectively. Most of the TEAEs and TRAEs were grade 1 or 2. Three patients achieved radiological partial response: an ORR of 13.6% based on RECIST 1.1. Ten patients (45.5%) achieved a major pathologic response (MPR, ≤10% viable tumor cells), including four (18.2%) had complete pathologic response (no viable tumor cell). There was a direct correlation between pathological response and decrease in the standardized uptake values (SUV) in the primary tumor. Among nine patients with 〉 30% decrease of SUV, eight had MPR, compared with no MRP response in the 11 patients with ≤30% decrease of SUV. Conclusions: Neoadjuvant sintilimab for sqNSCLC patients was tolerable and the 45.5% MRP rate is encouraging. A decrease in SUV may be predictive of pathologic response after PD-1 therapy in sqNSCLC. Clinical trial information: ChiCTR-OIC-17013726.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2019.37.15_suppl.8531
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2019
    detail.hit.zdb_id: 2005181-5
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  • 3
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    Prognostic significance of eighth edition TNM stage criteria in combined small-cell lung cancer
    Frontiers Media SA ; 2023
    In:  Frontiers in Oncology Vol. 13 ( 2023-3-8)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 13 ( 2023-3-8)
    Abstract: This study aimed to evaluate the prognostic significance of the eighth edition TNM stage criteria in patients with combined small-cell lung cancer (C-SCLC) on a population level. Methods Using the Surveillance, Epidemiology, and End Results (SEER) database, patients diagnosed with C-SCLC (histology code 8245) between the years 2004 and 2015 were identified. We performed a Kaplan–Meier analysis and used the multivariable cox regression proportional hazards model to obtain prognostic overall survival estimates for each group of patients. Results A total of 477 patients diagnosed with C-SCLC were identified. The T, N, M, TNM, and combined TNM stage status of the eighth edition were all significant prognostic factors for patients’ overall survivals, with the best discrimination identified in the combined stages. Surgery was also found to be a prognostic factor (HR =1.95, 95%CI =1.49-2.56, p & lt;0.01) for patients with C-SCLC. Conclusions The combined eighth edition of the TNM staging criteria shows reliable prognostic significance in patients with C-SCLC. Moreover, surgery might be significant for improving the patients’ prognosis.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    DOI: 10.3389/fonc.2023.1018288
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2649216-7
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  • 4
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    Risk factors and predictive scoring system for twice or more strokes in patients with cerebral small vessel disease
    ASEAN Neurological Association ; 2022
    In:  Neurology Asia Vol. 27, No. 3 ( 2022-9), p. 567-573
    Details
    In: Neurology Asia, ASEAN Neurological Association, Vol. 27, No. 3 ( 2022-9), p. 567-573
    Abstract: Objectives To explore the independent risk factors of twice or more strokes in patients with cerebral small vessel disease, and to construct a predictive scoring system. Methods A retrospective study was carried out in Tangshan, Hebei Province, China. Patients with cerebral small vessel disease suffered from acute stroke and admitted to Neurology Department of Tangshan Gongren Hospital from January 2020 to June 2021 were collected and grouped according to whether they had a previous stroke history. Binary logistic regression models were used to investigate the independent risks for the occurrence of twice or more strokes in patients with cerebral small vessel disease, assigned scores to each factor, then established and evaluated the predictive efficacy of the predictive scoring system. Results A total of 531 patients were included. Regression analysis showed that age, hypertension, diabetes, intracranial arterial stenosis, and total cerebral small vessel disease burden were independent risk factors. On the basis of each regression coefficient, a 10-point predictive scoring system selected the highest Jordon index as the cut-off value, which was 4 points. And the area under the receiver operating characteristic curve was 0.842 (95 %CI: 0.796~0.893, P＜0.001). Conclusions The predictive scoring system based on age, hypertension, diabetes, intracranial arterial stenosis, and total cerebral small vessel disease burden can effectively predict whether patients with cerebral small vessel disease are tend to be onset with twice or more strokes.
    Type of Medium: Online Resource
    ISSN: 1823-6138
    URL: Article
    DOI: 10.54029/2022kms
    Language: Unknown
    Publisher: ASEAN Neurological Association
    Publication Date: 2022
    detail.hit.zdb_id: 2571198-2
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  • 5
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    Online Resource
    Synergistic effect of sunlight induced photothermal conversion and H2O2 release based on hybridized tungsten oxide gel for cancer inhibition
    Springer Science and Business Media LLC ; 2016
    In:  Scientific Reports Vol. 6, No. 1 ( 2016-10-24)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2016-10-24)
    Abstract: A highly efficient photochromic hydrogel was successfully fabricated via casting precursor, which is based on amorphous tungsten oxide and poly (ethylene oxide)- block -poly (propylene oxide)- block -poly (ethylene oxide). Under simulated solar illumination, the hydrogel has a rapid and controlled temperature increasing ratio as its coloration degree. Localized electrons in the amorphous tungsten oxide play a vital role in absorption over a broad range of wavelengths from 400 nm to 1100 nm, encompassing the entire visible light and infrared regions in the solar spectrum. More importantly, the material exhibits sustainable released H 2 O 2 induced by localized electrons, which has a synergistic effect with the rapid surface temperature increase. The amount of H 2 O 2 released by each film can be tuned by the light irradiation, and the film coloration can indicate the degree of oxidative stress. The ability of the H 2 O 2 -releasing gels in vitro study was investigated to induce apoptosis in melanoma tumor cells and NIH 3T3 fibroblasts. The in vivo experimental results indicate that these gels have a greater healing effect than the control in the early stages of tumor formation.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/srep35876
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2615211-3
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  • 6
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    Specific organ metastases and prognosis in lung adenocarcinoma
    Wiley ; 2023
    In:  Thoracic Cancer Vol. 14, No. 8 ( 2023-03), p. 736-745
    Details
    In: Thoracic Cancer, Wiley, Vol. 14, No. 8 ( 2023-03), p. 736-745
    Abstract: This study aims to characterize the specific organ metastatic rates in lung adenocarcinoma (LUAD) patients and identify the prognosis‐associated factors. Methods Using the Surveillance, Epidemiology and End Results database, 40 117 patients diagnosed with positive histology as the only primary LUAD were included. We stratified patients by diagnosed year, age, sex, race/ethnicity, marital status, insurance, location, TNM stage, organ‐specific metastases, surgery, chemotherapy, and radiation therapy. We performed multivariable logistic and Cox regression to identify the factors associated with the presence of specific organ metastases and prognosis predictors. Results For the 40 117 LUAD patients, 43.69%, 26.25%, 19.66%, 10.60%, and 17.89% had specific organ, bone, brain, liver, and lung metastases, respectively. The average survival in patients with organ metastases was 12.19 months, compared to 36.40 months in patients without metastases. In different kinds of metastatic organ cohorts, the longest average survival was 12.60 months in the lung metastases cohort, and the shortest was 8.43 months in liver metastases cohort. In total, 571 patients with metastases received surgery, which was significantly associated with decreased mortality (hazard ratio 1.82, 95% confidence interval 1.65–2.01, p   〈  0.01). Patients received surgery of lobectomy or extended (251 of 571, 43.96%) displayed the longest average survival (35.16 months); patients (294 of 571, 51.49%) received sub‐lobar resection, had the average survival (19.90 months); patients received local tumor destruction (26 of 571, 4.55%) had the shortest average survival (13.73 months). Conclusion This study provides insights into the specific organ metastatic rates and prognosis in LUAD patients on a population level. These findings suggest that surgery resection should be taken into consideration in the treatment for these LUAD patients.
    Type of Medium: Online Resource
    ISSN: 1759-7706 , 1759-7714
    URL: Issue
    URL: Article
    DOI: 10.1111/tca.v14.8
    DOI: 10.1111/1759-7714.14801
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2559245-2
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  • 7
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    Two-year follow-up of single PD-1 blockade in neoadjuvant resectable NSCLC.
    American Society of Clinical Oncology (ASCO) ; 2021
    In:  Journal of Clinical Oncology Vol. 39, No. 15_suppl ( 2021-05-20), p. 8522-8522
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 39, No. 15_suppl ( 2021-05-20), p. 8522-8522
    Abstract: 8522 Background: Early stage non-small-cell lung cancer (NSCLC) could benefit from anti-programmed cell death-1 (PD-1) monotherapy; however, the survival profiles remain to be disclosed. Here, we presented the two-year follow-up outcomes from a phase 1b study of sintilimab, an anti-PD-1 inhibitor in the neoadjuvant setting of NSCLC. Methods: Treatment-naive pts with resectable NSCLC (stage IA–IIIB) received two cycles of sintilimab followed by surgical resection. Postoperative treatment of sintilimab was at the discretion of investigator. The primary endpoint was AE, and key secondary endpoints included major pathological response (MPR), disease free survival (DFS) rate of 1 year and 2 years, and overall survival (OS) rate of 2 years. Results: Among 40 enrolled pts, 36 (90%) underwent R0 resection and were included in the R0 resection population. By data cutoff (January 20, 2021), the median follow-up for DFS and OS for all the enrolled pts was 23.9 (IQR 20.5–24.4) months and 26.4 (IQR 24.2–29.0) months. A total of 12 (33.3%) pts experienced relapse, and 6 pts died. The 1-yr and 2-yr DFS rate was 91.7%/73.3%. The 2-yr OS rate for overall population and R0 population was 87.5%/91.7%, respectively. In the R0 resection population, the median DFS and OS were both not reached. Superior 2-year DFS rates were observed in pts who achieved MPR (MPR vs. Non-MPR: 86.7% vs. 63.8%). DFS of pts with non-squamous cell carcinoma tended to be shorter than that of pts with squamous cell carcinoma (HR 2.71 [95%CI 0.67–11.0], p=0.1479). Pts with tumor mutation burden (TMB) ≥10 mutations/Mb and PD-L1 tumor proportion score (TPS)≥50% tended to have a better 2-yr DFS rate compared to those with TMB 〈 10 and TPS 〈 50. [table] For the post-hoc event free survival (EFS) analysis, the same trend was observed with DFS among different subgroups, and patients with TMB ≥10 mutations/Mb had a significant improved EFS (HR 0.125[95% CI 0.02,1.03] , P=0.0222). Conclusions: Anti-PD-1 monotherapy emerged to be a promising neoadjuvant therapeutic strategy for resectable NSCLC with improved clinical outcomes. MPR could serve as a surrogate efficacy biomarker in this setting. Clinical trial information: ChiCTR-OIC-17013726. [Table: see text]
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2021.39.15_suppl.8522
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2021
    detail.hit.zdb_id: 2005181-5
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  • 8
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    Three Dimensional and Homogenous Single Cell Cyclic Stretch within a Magnetic Micropillar Array (mMPA) for a Cell Proliferation Study
    American Chemical Society (ACS) ; 2016
    In:  ACS Biomaterials Science & Engineering Vol. 2, No. 1 ( 2016-01-11), p. 65-72
    Details
    In: ACS Biomaterials Science & Engineering, American Chemical Society (ACS), Vol. 2, No. 1 ( 2016-01-11), p. 65-72
    Type of Medium: Online Resource
    ISSN: 2373-9878 , 2373-9878
    URL: Article
    URL: Article
    DOI: 10.1021/acsbiomaterials.5b00381
    DOI: 10.1021/acsbiomaterials.5b00381.s001
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2016
    detail.hit.zdb_id: 2806065-9
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  • 9
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    Controlled H 2 O 2 release via long-lived electron–hole separation mediated to induce tumor cell apoptosis
    Royal Society of Chemistry (RSC) ; 2015
    In:  Journal of Materials Chemistry B Vol. 3, No. 41 ( 2015), p. 8115-8122
    Details
    In: Journal of Materials Chemistry B, Royal Society of Chemistry (RSC), Vol. 3, No. 41 ( 2015), p. 8115-8122
    Type of Medium: Online Resource
    ISSN: 2050-750X , 2050-7518
    URL: Article
    DOI: 10.1039/C5TB00186B
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2015
    detail.hit.zdb_id: 2702241-9
    detail.hit.zdb_id: 2705149-3
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  • 10
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    Immunomagnetic‐bead enriched culturomics (IMBEC) for isolating pathobionts from feces of colorectal cancer patients
    Wiley ; 2023
    In:  iMeta Vol. 2, No. 2 ( 2023-05)
    Details
    In: iMeta, Wiley, Vol. 2, No. 2 ( 2023-05)
    Abstract: We have developed a novel method called immunomagnetic bead‐enriched culturomics (IMBEC) to enrich and isolate colorectal cancer‐related pathobionts. This method combines immunomagnetic beads and culturomics technology. IMBEC can be targeted to isolate more bacterial species associated with cancer or inflammation, and can be accurate to the strain level. Bacterial DNA is not only detected in the blood of colorectal cancer patients but also in the serum of patients with other diseases, so IMBEC can also be employed in other diseases to isolate pathobionts.
    Type of Medium: Online Resource
    ISSN: 2770-596X , 2770-596X
    URL: Issue
    URL: Article
    DOI: 10.1002/imt2.v2.2
    DOI: 10.1002/imt2.100
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 3114873-6
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