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  • 1
    Online Resource
    Online Resource
    Image_1.TIF
    Frontiers Media SA ; 2021
    In:  Frontiers in Genetics Vol. 12 ( 2021-5-4)
    Details
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 12 ( 2021-5-4)
    Abstract: Chaperonin-containing TCP1 subunit (CCT) 6A is an oncogenic 6th subunit of the CCT family. Nevertheless, not much is documented regarding its function in colorectal cancer (COAD). This investigation seeks to explore the role of CCT6A in the prognosis of COAD. Main Methods Sequencing data from the Gene Expression Omnibus (GEO) and Cancer Genome Atlas database (TCGA) were employed to analyze the expression of CCT6A and its involvement in various regulatory networks behind COAD. Oncomine and Gene Expression Profiling Interactive Analysis (GEPIA) analyzed Levels of expression and survival rates, while GEPIA was used to uncover further the functional networks that involved CCT6A . Database for Annotation, Visualization, and Integrated Discovery (DAVID) tools were used to interpret Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. Evaluation of the expression levels of CCT6A in COAD samples was also verified via immunohistochemistry. Key Findings We found that the expression of CCT6A is up-regulated in COAD. CCT6A correlated with poor prognosis and decreased immune infiltrates such as CD4 + T cells, B cells, and dendritic cells. CCT6A is increased in COAD patients. CCT6A is associated with several gene networks related to the DDX family and mismatch repair pathways. Significance Our data showed that data mining was able to uncover data regarding levels of CCT6A and its involvement in genetic regulating pathways in COAD.
    Type of Medium: Online Resource
    ISSN: 1664-8021
    URL: Article
    URL: Article
    DOI: 10.3389/fgene.2021.629856
    DOI: 10.3389/fgene.2021.629856.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2606823-0
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  • 2
    Online Resource
    Online Resource
    Overexpression of ATP ‐binding cassette transporter Mdr49‐like confers resistance to imidacloprid in the field populations of brown planthopper, Nilaparvata lugens
    Wiley ; 2022
    In:  Pest Management Science Vol. 78, No. 2 ( 2022-02), p. 579-590
    Details
    In: Pest Management Science, Wiley, Vol. 78, No. 2 ( 2022-02), p. 579-590
    Abstract: The brown planthopper (BPH), Nilaparvata lugens (Stål), is the most severe pest attacking rice crops using sucking mouthparts. It causes significant damages to rice growth and food production worldwide. With the long‐term and wide use of insecticides, field populations of BPH have developed resistance to many insecticides. RESULTS Here, we showed that upregulation of an ATP‐binding cassette transporter gene NlMdr49‐like contributes to imidacloprid resistance in field populations of BPH. A comparative transcriptome analysis was performed to evaluate the gene expression in two field populations (JXSG18 and YNTC18). Compared with a susceptible strain (Sus), 202 upregulated genes and 170 downregulated genes were identified in both field populations. Functional enrichment analysis revealed that the differentially expressed genes (DEGs) are mainly linked to metabolic process and transmembrane transport. Among the candidate DEGs, NlMdr49‐like was significantly upregulated in both field populations. Based on the genome and transcriptome of BPH, the full‐length complementary DNA of NlMdr49‐like was sequenced and its molecular characteristics were analyzed. Expression pattern analysis of various tissues showed that NlMdr49‐like was predominantly expressed in midgut and Malpighian tubules which are important excretion organs. Knocking down NlMdr49‐like reduced BPH resistance to imidacloprid, but did not affect its resistance to the other nine insecticides (chlorpyrifos, thiamethoxam, nitenpyram, dinotefuran, sulfoxaflor, triflumezopyrim, ethiprole, buprofezin and pymetrozine). Furthermore, a transgenic strain of Drosophila melanogaster overexpressing NlMdr49‐like was less susceptible to imidacloprid. CONCLUSIONS Our findings indicate that upregulation of NlMdr49‐like is another mechanism contributing to imidacloprid resistance in N. lugens . This result is helpful to further understand the resistance mechanism of N. lugens to imidacloprid. © 2021 Society of Chemical Industry.
    Type of Medium: Online Resource
    ISSN: 1526-498X , 1526-4998
    URL: Issue
    URL: Article
    DOI: 10.1002/ps.v78.2
    DOI: 10.1002/ps.6666
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2003455-6
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Effects of nicotinic acetylcholine receptor subunit deletion mutants on insecticide susceptibility and fitness in Drosophila melanogaster
    Wiley ; 2022
    In:  Pest Management Science Vol. 78, No. 8 ( 2022-08), p. 3519-3527
    Details
    In: Pest Management Science, Wiley, Vol. 78, No. 8 ( 2022-08), p. 3519-3527
    Abstract: Nicotinic acetylcholine receptors (nAChRs) are major excitatory neurotransmitter receptors in insects and also the target site for many insecticides. Unfortunately, the effectiveness of these insecticides is diminishing as a consequence of the evolution of insecticide resistance. Further exploration of insecticide targets is important to sustainable pest management. RESULTS In order to validate the role of nAChR subunits in insecticide susceptibility and test whether the subunit's absence imposes the fitness cost on insects, we determined the susceptibility of eight nAChR subunit deletion mutants of Drosophila melanogaster to nine insecticides. These findings highlighted the specific resistance of the D α6 deletion mutant to spinosyns. Although triflumezopyrim, dinotefuran and imidacloprid are competitive modulators of nAChRs, differences in susceptibility of the insect with different deletion mutants suggested that the target sites of these three insecticides do not overlap completely. Mutants showed decreased susceptibility to insecticides, accompanied by a reduction in fitness. The number of eggs produced by D α1 attP , D α2 attP , D β2 attP and D β3 attP females was significantly lesser than that of the vas‐Cas9 strain as the control. In addition, adults of D α2 attP , D α3 attP and D α7 attP strains showed lower climbing performance. Meanwhile, males of D α3 attP , D α5 attP , D β2 attP and D β3 attP , and females of D β2 attP showed significantly shorter longevity than those of the vas‐Cas9 strain. CONCLUSION This study provides new insights into the interactions of different insecticides with different nAChRs subunit in D. melanogaster as a research model, it could help better understand such interaction in agricultural pests whose genetic manipulations for toxicological research are often challenging. © 2022 Society of Chemical Industry.
    Type of Medium: Online Resource
    ISSN: 1526-498X , 1526-4998
    URL: Issue
    URL: Article
    DOI: 10.1002/ps.v78.8
    DOI: 10.1002/ps.6992
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2003455-6
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Interferon-beta inhibits human glioma stem cell growth by modulating immune response and cell cycle related signaling pathways
    Springer Science and Business Media LLC ; 2022
    In:  Cell Regeneration Vol. 11, No. 1 ( 2022-12)
    Details
    In: Cell Regeneration, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2022-12)
    Abstract: Malignant Glioma is characterized by strong self-renewal potential and immature differentiation potential. The main reason is that malignant glioma holds key cluster cells, glioma stem cells (GSCs). GSCs contribute to tumorigenesis, tumor progression, recurrence, and treatment resistance. Interferon-beta (IFN-β) is well known for its anti-proliferative efficacy in diverse cancers. IFN-β also displayed potent antitumor effects in malignant glioma. IFN-β affect both GSCs and Neural stem cells (NSCs) in the treatment of gliomas. However, the functional comparison, similar or different effects of IFN-β on GSCs and NSCs are rarely reported. Here, we studied the similarities and differences of the responses to IFN-β between human GSCs and normal NSCs. We found that IFN-β preferentially inhibited GSCs over NSCs. The cell body and nucleus size of GSCs increased after IFN-β treatment, and the genomic analysis revealed the enrichment of the upregulated immune response, cell adhesion genes and down regulated cell cycle, ribosome pathways. Several typical cyclin genes, including cyclin A2 ( CCNA2) , cyclin B1 ( CCNB1) , cyclin B2 ( CCNB2), and cyclin D1 ( CCND1) , were significantly downregulated in GSCs after IFN-β stimulation. We also found that continuous IFN-β stimulation after passage further enhanced the inhibitory effect. Our study revealed how genetic diversity resulted in differential effects in response to IFN-β treatment. These results may contribute to improve the applications of IFN-β in anti-cancer immunotherapy. In addition, these results may also help to design more effective pharmacological strategies to target cancer stem cells while protecting normal neural stem cells.
    Type of Medium: Online Resource
    ISSN: 2045-9769
    URL: Article
    DOI: 10.1186/s13619-022-00123-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2682438-3
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  • 5
    Online Resource
    Online Resource
    CTA Characteristics of the Circle of Willis and Intracranial Aneurysm in a Chinese Crowd with Family History of Stroke
    Hindawi Limited ; 2016
    In:  BioMed Research International Vol. 2016 ( 2016), p. 1-11
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2016 ( 2016), p. 1-11
    Abstract: Background and Purpose. The vascular morphology in crowd with family history of stroke remains unclear. The present study clarified the characteristics of the intracranial vascular CoW and prevalence of intracranial aneurysms in subjects with family history of stroke. Methods. A stratified cluster, random sampling method was used for subjects with family history of stroke among rural residents in Jixian, Tianjin, China. All the subjects underwent a physical examination, head computed tomography (CT) scan, and cephalic and cervical computed tomography angiography (CTA) scan. Anatomic variations in the Circle of Willis and cerebrovascular disease in this population were analyzed. Results. In the crowd with similar living environment, stable genetic background, and family history of stroke and without obvious nerve function impairment (1) hypoplasia or absence of A1 segment was significantly different in gender (male versus female: 9.8% versus 18.8%, p = 0.031 ), especially the right-side A1 (male versus female: 5.9% versus 16.4%, p = 0.00 4 ). (2) Hypoplasia or absence of bilateral posterior communicating arteries was more common in men than women (58.2% versus 45.3%, p = 0.032 ). Unilateral fetal posterior cerebral artery was observed more often in women than men (17.2% versus 8.5%, p = 0.028 ). (3) The percentage of subjects with incomplete CoW did not increase significantly with age. Compared to healthy Chinese people, the crowd had a higher percentage of incomplete CoW ( p 〈 0.00 1 ). (4) No obvious correlation between risk factors and CoW was found. (5) The prevalence of aneurysm was 10.3% in the special crowd. Conclusions. The certain variations of CoW showed significant relation to gender, but not to age in people with family history of stroke. The incomplete circle may be a dangerous factor that is independent of common risk factors for stroke and tend to lead to cerebral ischemia in the crowd with family history of stroke. The prevalence of intracranial aneurysm is comparatively high in the present subjects compared to other people.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2016/1743794
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2698540-8
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  • 6
    Online Resource
    Online Resource
    Influence of arm position change from adduction to abduction on intracavitary electrocardiogram
    SAGE Publications ; 2021
    In:  The Journal of Vascular Access Vol. 22, No. 2 ( 2021-03), p. 292-298
    Details
    In: The Journal of Vascular Access, SAGE Publications, Vol. 22, No. 2 ( 2021-03), p. 292-298
    Abstract: The aim of this study is to evaluate the influence of arm movements from adduction to abduction on intracavitary electrocardiogram and the position of a catheter tip. Methods: Overall, 192 peripherally inserted central catheter lines were placed under intracavitary electrocardiogram guidance and 188 of them were enrolled in the study. The catheter was first placed at a time point corresponding to the peak P wave with the arm in adduction. The arm was then abducted to 90° without changing catheter insertion length. During the procedure, basal electrocardiogram, intracavitary electrocardiogram, and radiographs with the arm in adduction and abduction were recorded. Amplitude wave changes and catheter movements were measured on electrocardiogram records and radiographs, respectively. Results: In 188 cases, the P wave displayed typical changes, and 97.8% (184/188) catheters were successfully placed correctly. At the peak P wave, the amplitude of the peak P wave was 8.64 times greater than that of the basal P wave, and the P/R ratio was 0.61. When the arm was abducted to 90°, the amplitude of the P wave dropped to 57% of its peak, P/R decreased from 0.61 to 0.34, and the catheter tip moved cephalad 1.00 and 0.77 vertebral body units in male and female patients, respectively. Conclusion: Peripherally inserted central catheter moves toward the heart when the arm position changes from abduction to adduction. Peripherally inserted central catheter tip placement at the peak P wave with patient’s arm in adduction is accurate and can prevent the catheter from advancing too low. R wave can function as a reference for observing P wave changes during peripherally inserted central catheter placement.
    Type of Medium: Online Resource
    ISSN: 1129-7298 , 1724-6032
    URL: Article
    DOI: 10.1177/1129729819891565
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2079292-X
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  • 7
    Online Resource
    Online Resource
    On the luminescent properties of Dy3+:β-Li2TiO3 comment on “Synthesis and emission analysis of RE3+ (Eu3+ or Dy3+):Li2TiO3 ceramics”
    Elsevier BV ; 2014
    In:  Ceramics International Vol. 40, No. 7 ( 2014-08), p. 11465-11467
    Details
    In: Ceramics International, Elsevier BV, Vol. 40, No. 7 ( 2014-08), p. 11465-11467
    Type of Medium: Online Resource
    ISSN: 0272-8842
    URL: Article
    DOI: 10.1016/j.ceramint.2014.03.097
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2014
    detail.hit.zdb_id: 2018052-4
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  • 8
    Online Resource
    Online Resource
    Immunogenicity and protective efficacy of a DNA vaccine inducing optimal expression of the SARS-CoV-2 S gene in hACE2 mice
    Springer Science and Business Media LLC ; 2022
    In:  Archives of Virology Vol. 167, No. 12 ( 2022-12), p. 2519-2528
    Details
    In: Archives of Virology, Springer Science and Business Media LLC, Vol. 167, No. 12 ( 2022-12), p. 2519-2528
    Type of Medium: Online Resource
    ISSN: 0304-8608 , 1432-8798
    URL: Article
    DOI: 10.1007/s00705-022-05562-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1458460-8
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Data_Sheet_1.doc
    Frontiers Media SA ; 2021
    In:  Frontiers in Nutrition Vol. 8 ( 2021-5-19)
    Details
    In: Frontiers in Nutrition, Frontiers Media SA, Vol. 8 ( 2021-5-19)
    Abstract: Background and Aims: The dietary inflammatory index (DII) is associated with non-communicable disease. We conducted an umbrella review to systematically evaluate meta-analyses of observational studies on DII and diverse health outcomes. Methods: We comprehensively searched the PubMed, Web of Science, and Embase databases to identify related systematic reviews and meta-analyses of observational studies. Those investigating the association between DII and a wide range of health outcomes in humans were eligible for inclusion. For each meta-analysis, we estimated the summary effect size by using fixed and random effects models, the 95% confidence interval, and the 95% prediction interval. We assessed heterogeneity, evidence of small-study effects, and excess significance bias. Results: The umbrella review identified 35 meta-analyses assessing associations between DII and various health outcomes: cancer ( n = 24), mortality ( n = 4), metabolic ( n = 4), and other ( n = 3). The methodological quality was high or moderate. Of the 35 meta-analyses, we observed highly suggestive evidence for harmful associations between digestive tract cancer, colorectal cancer, overall cancer, pharyngeal cancer, UADT cancer, and CVD mortality. Moreover, 11 harmful associations showed suggestive evidence: hormone-dependent cancer, rectal cancer, colon cancer, breast and prostate cancer, gynecological cancer, breast cancer, ovarian cancer, colorectal cancer, prostate cancer, all-cause mortality, and depression. Conclusion: DII is likely to be associated with harmful effects in multiple health outcomes. Robust randomized controlled trials are warranted to understand whether the observed results are causal. Systematic Review Registration: CRD42021218361
    Type of Medium: Online Resource
    ISSN: 2296-861X
    URL: Article
    URL: Article
    DOI: 10.3389/fnut.2021.647122
    DOI: 10.3389/fnut.2021.647122.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2776676-7
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  • 10
    Online Resource
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    Study on anti-corrosion performance and mechanism of epoxy coatings based on basalt flake loaded aniline trimer
    Elsevier BV ; 2021
    In:  Colloid and Interface Science Communications Vol. 45 ( 2021-11), p. 100505-
    Details
    In: Colloid and Interface Science Communications, Elsevier BV, Vol. 45 ( 2021-11), p. 100505-
    Type of Medium: Online Resource
    ISSN: 2215-0382
    URL: Article
    DOI: 10.1016/j.colcom.2021.100505
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2831414-1
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