In:
Frontiers in Cellular and Infection Microbiology, Frontiers Media SA, Vol. 14 ( 2024-2-7)
Abstract:
Tuberculosis (TB), particularly drug-resistant TB (DR-TB), remains a significant public health concern in Ningbo, China. Understanding its molecular epidemiology and spatial distribution is paramount for effective control. Methods From December 24, 2020, to March 12, 2023, we collected clinical Mycobacterium tuberculosis (MTB) strains in Ningbo, with whole-genome sequencing performed on 130 MTB strains. We analyzed DR-related gene mutations, conducted phylogenetic and phylodynamic analyses, identified recent transmission clusters, and assessed spatial distribution. Results Among 130 DR-TB cases, 41% were MDR-TB, 36% pre-XDR-TB, 19% RR-TB, and 3% HR-TB. The phylogenetic tree showed that 90% of strains were Lineage 2 (Beijing genotype), while remaining 10% were Lineage 4 (Euro-American genotype). The spatial analysis identified hotspots of DR-TB in Ningbo’s northern region, particularly in traditional urban centers. 31 (24%) of the DR-TB cases were grouped into 7 recent transmission clusters with a large outbreak cluster containing 15 pre-XDR-TB patients. Epidemiological analyses suggested a higher risk of recent DR-TB transmission among young adult patients who frequently visited Internet cafes, game rooms, and factories. Conclusion Our study provides comprehensive insights into the epidemiology and genetics of DR-TB in Ningbo. The presence of genomic clusters highlights recent transmission events, indicating the need for targeted interventions. These findings are vital for informing TB control strategies in Ningbo and similar settings.
Type of Medium:
Online Resource
ISSN:
2235-2988
DOI:
10.3389/fcimb.2024.1327477
DOI:
10.3389/fcimb.2024.1327477.s001
DOI:
10.3389/fcimb.2024.1327477.s002
DOI:
10.3389/fcimb.2024.1327477.s003
DOI:
10.3389/fcimb.2024.1327477.s004
DOI:
10.3389/fcimb.2024.1327477.s005
DOI:
10.3389/fcimb.2024.1327477.s006
DOI:
10.3389/fcimb.2024.1327477.s007
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2024
detail.hit.zdb_id:
2619676-1
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