In:
The International Journal of Artificial Organs, SAGE Publications, Vol. 32, No. 1 ( 2009-01), p. 43-49
Abstract:
Myocardial revascularization using a complete heart-lung machine may involve many problems, as do complete off-pump attempts. Thus, it was the aim of this study to evaluate the effects of intermediate on-pump/off-pump myocardial revascularization using the miniaturized Deltastream blood pump, on ischemia and hemolysis, in comparison with standard myocardial revascularization. Methods In a group of 8 mini-pigs, combined on-pump/off-pump myocardial revascularization was performed using the Deltastream blood pump as beating-heart support for the on-pump part of the operation (group A). Seven other animals served as controls and underwent standard myocardial revascularization with the same device as integrated pump of a complete heart-lung machine (group B). Blood samples for blood gas metabolism, creatine kinase (CK), troponin I, lactate dehydrogenase (LDH), and hydroxybutyrate dehydrogenase (HBDH) were taken before and after the entire operation. Results Comparing the baseline values, the increase of CK was more pronounced in group B than in group A (176.4 ± 41.2 to 279.7 ± 29 U/L vs. 274 ± 142.7 to 288.1 ± 118.6 U/L, respectively; p=0.0006). Increase of troponin I was significantly higher in group B than in group A (1 ± 0.3 to 2.9 ± 1 ng/mL vs. 1.1 ± 0.9 to 3 ± 3.8 ng/mL, respectively; p=0.002). LDH increase was also more pronounced in group B (231.7 ± 54.3 to 299.9 ± 39.8 U/L vs. 274.9 ± 59.7 to 263.8 ± 57.9 U/L, respectively; p=0.01). HBDH values increased significantly in group B after the operation (group A: 215.9 ± 34.7 to 200 ± 39.2 U/L vs. group B: 195.4 ± 41.7 to 274.9 ± 51.6 U/L; p=0.02). Hemodynamic measures and LDH values under luxation (group A: 1.9 ± 0.6 U/L; B: 3.5 ± 1 U/L, p=0.001) were also superior in the study group. Conclusion The current set-up might be superior to conventional extracorporeal circulation and thus be an alternative for high-risk candidates to avoid the adverse events of a complete heart-lung machine, when they are scheduled for complete myocardial revascularization.
Type of Medium:
Online Resource
ISSN:
0391-3988
,
1724-6040
DOI:
10.1177/039139880903200106
Language:
English
Publisher:
SAGE Publications
Publication Date:
2009
detail.hit.zdb_id:
1474999-3
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