In:
International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 23 ( 2022-12-03), p. 16206-
Abstract:
The improvement of laboratory diagnosis is a critical step for the reduction of syphilis cases around the world. In this paper, we present the development of an impedance-based method for detecting T. pallidum antigens and antibodies as an auxiliary tool for syphilis laboratory diagnosis. We evaluate the voltammetric signal obtained after incubation in carbon or gold nanoparticle-modified carbon electrodes in the presence or absence of Poly-L-Lysine. Our results indicate that the signal obtained from the electrodes was sufficient to distinguish between infected and non-infected samples immediately (T0′) or 15 min (T15′) after incubation, indicating its potential use as a point-of-care method as a screening strategy.
Type of Medium:
Online Resource
ISSN:
1660-4601
DOI:
10.3390/ijerph192316206
Language:
English
Publisher:
MDPI AG
Publication Date:
2022
detail.hit.zdb_id:
2175195-X
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