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  • 1
    Online Resource
    Online Resource
    Clinical Relevance of SOCS1 and SOCS3 in Patients with Oral Squamous Cell Carcinoma
    Columbia International Publishing ; 2017
    In:  American Journal of Cancer Research and Clinical Oncology ( 2017)
    Details
    In: American Journal of Cancer Research and Clinical Oncology, Columbia International Publishing, ( 2017)
    Type of Medium: Online Resource
    ISSN: 2163-1085
    URL: Article
    DOI: 10.7726/ajcrco.2017.1001
    Language: Unknown
    Publisher: Columbia International Publishing
    Publication Date: 2017
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  • 2
    Online Resource
    Online Resource
    Significance of Interleukin-6 in Papillary Thyroid Carcinoma
    Hindawi Limited ; 2016
    In:  Journal of Thyroid Research Vol. 2016 ( 2016), p. 1-12
    Details
    In: Journal of Thyroid Research, Hindawi Limited, Vol. 2016 ( 2016), p. 1-12
    Abstract: This study sought to reveal the significance of IL-6 in papillary thyroid carcinoma by determining its circulating levels, tumoral protein, and mRNA expressions. As compared to the healthy individuals, serum IL-6 was significantly higher in patients with benign thyroid diseases and PTC. Further, its level was significantly higher in PTC patients as compared to patients with benign thyroid diseases. ROC curves also confirmed a good discriminatory efficacy of serum IL-6 between healthy individuals and patients with benign thyroid diseases and PTC. The circulating IL-6 was significantly associated with poor overall survival in PTC patients. IL-6 immunoreactivity was significantly high in PTC patients as compared to the benign thyroid disease patients. Significantly higher IL-6 mRNA expression was also observed in the primary tumour tissues of PTC patients than the adjacent normal tissues. The protein expression of IL-6 at both the circulating and tissue level correlated with disease aggressiveness in PTC patients. Moreover, a significant positive correlation was observed between the IL-6 protein and mRNA expression in the primary tumours of PTC patients. Finally in conclusion, IL-6 has an important role in thyroid cancer progression. Thus targeting IL-6 signalling can help in clinical management of thyroid carcinoma patients.
    Type of Medium: Online Resource
    ISSN: 2090-8067 , 2042-0072
    URL: Article
    DOI: 10.1155/2016/6178921
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2549014-X
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  • 3
    Online Resource
    Online Resource
    A comparative evaluation of Regulatory requirements for Registration of Dietary Supplements in Brazil, Russia, India, China and South Africa
    Society of Pharmaceutical Tecnocrats ; 2023
    In:  International Journal of Drug Regulatory Affairs Vol. 11, No. 3 ( 2023-09-19), p. 53-61
    Details
    In: International Journal of Drug Regulatory Affairs, Society of Pharmaceutical Tecnocrats, Vol. 11, No. 3 ( 2023-09-19), p. 53-61
    Abstract: Nutraceuticals are products that are rich in nutrients and provide health benefits, because of many factors like lifestyle changes and change in the dietary habits of people now a day, these products are widely used. Among all the other categories of Nutraceuticals Dietary supplement comprises huge part of Nutraceuticals. They are distinguishable from conventional food or drugs. They are intended to use to supplement the normal diet. The terms, nomenclature and definitions of the dietary supplements vary throughout the world. Different countries have their own regulation and legislative requirements. In regulated countries streamlined regulations are there, while well-structured and streamlined regulations for Nutraceuticals are lacking in other countries. In developing and emerging nations the regulation of dietary supplements are constantly evolving. It is necessary that the product complies all the regulatory requirements before they are placed on the market. The proposed study is based on the regulation and legislative requirements of dietary supplements in Brazil, Russia, India and South Africa.
    Type of Medium: Online Resource
    ISSN: 2321-6794 , 2321-7162
    URL: Article
    DOI: 10.22270/ijdra.v11i3.616
    Language: Unknown
    Publisher: Society of Pharmaceutical Tecnocrats
    Publication Date: 2023
    detail.hit.zdb_id: 2738279-5
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Significance of TNF- α and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma
    Hindawi Limited ; 2016
    In:  Journal of Thyroid Research Vol. 2016 ( 2016), p. 1-17
    Details
    In: Journal of Thyroid Research, Hindawi Limited, Vol. 2016 ( 2016), p. 1-17
    Abstract: Circulating levels of TNF- α and the adhesion molecules L-Selectin and VCAM-1 as well as their expression in the primary tumors of patients with benign thyroid diseases and papillary thyroid carcinoma (PTC) have been determined in this study. The serum levels of TNF- α , L-Selectin, and VCAM-1 were significantly higher in patients with both benign thyroid diseases and PTC as compared to the healthy individuals. However, the levels of only TNF- α and L-Selectin, and not VCAM-1, were significantly higher in patients with PTC in comparison to those observed in patients with benign thyroid diseases. Further the expression of TNF- α and L-Selectin was also significantly higher in the primary tumors of PTC patients, relative to the benign thyroid diseases. The expression of L-Selectin and VCAM-1 significantly correlated with aggressive tumor behavior. In PTC patients, the circulating TNF- α levels significantly positively correlated with the levels of L-Selectin, while TNF- α immunoreactivity was significantly associated with VCAM-1 expression. Serum TNF- α was found to be a significant prognosticator for OS in PTC patients. Overall the results signify that the interaction between TNF- α and the adhesion molecules may have a role in thyroid carcinogenesis and understanding this complexity may offer potential therapeutic targets for better management of thyroid cancer.
    Type of Medium: Online Resource
    ISSN: 2090-8067 , 2042-0072
    URL: Article
    DOI: 10.1155/2016/8143695
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2549014-X
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  • 5
    Online Resource
    Online Resource
    Array comparative genomic hybridization analysis of products of conception in recurrent pregnancy loss for specific anomalies detected by USG
    Bioscientifica ; 2023
    In:  Reproduction and Fertility Vol. 4, No. 2 ( 2023-04-01)
    Details
    In: Reproduction and Fertility, Bioscientifica, Vol. 4, No. 2 ( 2023-04-01)
    Abstract: To evaluate the proportion of chromosomal abnormalities in recurrent pregnancy loss (RPL) assisted by array comparative genomic hybridization (aCGH) bright out with higher detection rate, more accuracy, and less sample failure as compared with conventional cytogenetic analysis. In this study, product of conception samples with abnormal ultrasonogram (USG) findings of the fetus and clinical history of RPL were first processed for karyotyping and fluorescence in situ hybridization (FISH) analysis. Normal results given by karyotype and FISH samples with major anomalies detected by ultrasound with RPL were divided into six groups and aCGH was performed to detect the gain or loss and copy number variations (CNVs) of a particular gene present in chromosomal segments. Among a total of 300 products of conception samples, 100 abnormal samples were identified either by karyotype ( n  = 70) or by FISH ( n  = 30). From the remaining 200 samples, 5 showed the presence of maternal cell contamination excluded. aCGH analysis revealed ( n  = 195) that 74 (38%) samples with CNVs and 2 samples with variants of unknown clinical significance were clinically associated with the clinical findings and 121(62%) samples showed no change in CNVs. The most frequent CNVs were loss of chromosome regions at 2q33.1, 7q11.21, 15q11.1, 16p11.2, Xp22.33, and Yp11.32. CNVs at arr[GRCh37]7p22.3,p21.2(830852-15124702)×1,7q34q36.3(141464180-158909738)×3, 14.2Mbp deletion of 7p22.3p21.2 (SUN1 gene) and 17.4Mbp duplication of 7q34q36.3 (KCNH2, CNTNAP2, and SHH genes) were found in one sample, and CNVs at arr[GRCh37] 8p22.2q22.3(86326349-105509986)×1 and 2.48Mbp deletion of 8p22.2q22.3 (GRHL1 gene) were found in another sample. Lay summary Recurrent pregnancy loss is considered as two or more consecutive pregnancy losses. Fetal birth defects are thoroughly associated with chromosomal (thread-like structures containing packaged genetic material) abnormalities, which are the underlying causes of pregnancy loss. The evaluation of chromosomal abnormalities is required to diagnose pregnancy loss to improve the prognosis of future pregnancies. The largest proportion of chromosomal abnormalities was observed in the fetal tissue that remains in the uterus after pregnancy. We analyzed 300 retained fetal tissue samples and implicated different methods to recognize the structural abnormalities in the chromosomes. Moreover, simultaneously detect the expression of thousands of genes from fetal tissue. A clinical indication and their association of chromosomal abnormalities were obtained in 38% of cases with assorted fetal ultrasound defects in multiple pregnancy losses and two samples with a variety of unknown clinical indications. It revealed that chromosomal alteration in fetal birth defects is responsible for multiple pregnancy losses.
    Type of Medium: Online Resource
    ISSN: 2633-8386
    URL: Article
    DOI: 10.1530/RAF-22-0092
    Language: Unknown
    Publisher: Bioscientifica
    Publication Date: 2023
    detail.hit.zdb_id: 3063977-3
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  • 6
    Online Resource
    Online Resource
    Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
    Elsevier BV ; 2022
    In:  The Lancet Vol. 400, No. 10363 ( 2022-11), p. 1607-1617
    Details
    In: The Lancet, Elsevier BV, Vol. 400, No. 10363 ( 2022-11), p. 1607-1617
    Type of Medium: Online Resource
    ISSN: 0140-6736
    URL: Article
    DOI: 10.1016/S0140-6736(22)01846-3
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2067452-1
    detail.hit.zdb_id: 3306-6
    detail.hit.zdb_id: 1476593-7
    SSG: 5,21
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  • 7
    Online Resource
    Online Resource
    High Adhesion and Increased Cell Death Contribute to Strong Biofilm Formation in Klebsiella pneumoniae
    MDPI AG ; 2019
    In:  Pathogens Vol. 8, No. 4 ( 2019-12-01), p. 277-
    Details
    In: Pathogens, MDPI AG, Vol. 8, No. 4 ( 2019-12-01), p. 277-
    Abstract: Klebsiella pneumoniae (Kp), is a frequent cause of hospital and community-acquired infections and WHO had declared it as a “priority pathogen”. Biofilm is a major virulence factor of Kp and yet the mechanism of strong biofilm formation in Kp is unclear. A key objective of the present study is to investigate the differences between strong and weak biofilms formed by clinical isolates of Kp on various catheters and in different media conditions and to identify constituents contributing to strong biofilm formation. Quantification of matrix components (extracellular DNA (eDNA), protein, exopolysaccharides (EPS), and bacterial cells), confocal laser scanning microscopy (CLSM), field emission gun scanning electron microscopy (FEG-SEM) and flow-cytometry analysis were performed to compare strong and weak biofilm matrix. Our results suggest increased biofilm formation on latex catheters compared to silicone and silicone-coated latex catheters. Higher amounts of eDNA, protein, EPS, and dead cells were observed in the strong biofilm of Kp. High adhesion capacity and cell death seem to play a major role in formation of strong Kp biofilms. The enhanced eDNA, EPS, and protein in the biofilm matrix appear as a consequence of increased cell death.
    Type of Medium: Online Resource
    ISSN: 2076-0817
    URL: Article
    DOI: 10.3390/pathogens8040277
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2695572-6
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  • 8
    Online Resource
    Online Resource
    Deciphering the potential value of 5-fluorouracil metabolic enzymes in predicting prognosis and treatment response of colorectal cancer patients
    SAGE Publications ; 2018
    In:  The International Journal of Biological Markers Vol. 33, No. 2 ( 2018-05), p. 180-188
    Details
    In: The International Journal of Biological Markers, SAGE Publications, Vol. 33, No. 2 ( 2018-05), p. 180-188
    Abstract: 5-flourouracil (5-FU) is one of the standard chemotherapeutic drugs used today in the treatment of colorectal cancer patients. Disruption of 5-FU metabolic pathway may contribute to altered effectiveness towards 5-FU-based therapy. Hence, the study of 5-FU metabolizing enzymes might have the potential efficacy to predict survival and response to treatment in colorectal cancer patients. Materials and methods: Immunohistochemical localization of 5-FU metabolic enzymes (TS, MTHFR, DPYD, and TP) was evaluated in 143 untreated patients with colorectal cancer; their prognostic and predictive values were also evaluated. Results: Immuno-positivity for TS, MTHFR, DPYD, and TP was observed in 77%, 75%, 88%, and 96% of colorectal cancer patients, respectively. Univariate survival analysis in total patients showed that low DPYD expression significantly predicted adverse overall survival ( P=0.042). Moreover, subgroup of colon cancer patients with low TS expression was associated with unfavorable prognosis. TP expression also emerged as a prognosticator in the subgroup of early and advanced stage patients. Additionally, when effect of co-expression of 5-FU metabolic enzymes was evaluated in total patients, low coexpression of all four proteins was predictive of poor overall survival than for individuals expressing high coexpression of these proteins ( P=0.045). In contrast, none of the 5-FU metabolic enzymes—either singly or on coexpression—emerged as a useful biomarker of potential therapeutic value when evaluated in the subgroup of patients treated with 5-FU alone or 5-FU plus oxaliplatin. Conclusion: The above findings suggest that coexpression of 5-FU metabolic enzymes possess significant prognostic value and could be useful biomarkers in colorectal cancer patients.
    Type of Medium: Online Resource
    ISSN: 1724-6008 , 1724-6008
    URL: Article
    DOI: 10.1177/1724600817748539
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 1475778-3
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  • 9
    Online Resource
    Online Resource
    ERCC1 expression in patients with colorectal cancer: a pilot study
    OAE Publishing Inc. ; 2016
    In:  Journal of Cancer Metastasis and Treatment Vol. 2, No. 12 ( 2016-12-29), p. 471-
    Details
    In: Journal of Cancer Metastasis and Treatment, OAE Publishing Inc., Vol. 2, No. 12 ( 2016-12-29), p. 471-
    Type of Medium: Online Resource
    ISSN: 2454-2857 , 2394-4722
    URL: Article
    DOI: 10.20517/2394-4722.2016.52
    Language: Unknown
    Publisher: OAE Publishing Inc.
    Publication Date: 2016
    detail.hit.zdb_id: 2819994-7
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  • 10
    Online Resource
    Online Resource
    Potential Role of KRAS and BRAF in Epithelial Ovarian Cancer
    Springer Science and Business Media LLC ; 2021
    In:  Indian Journal of Gynecologic Oncology Vol. 19, No. 2 ( 2021-05)
    Details
    In: Indian Journal of Gynecologic Oncology, Springer Science and Business Media LLC, Vol. 19, No. 2 ( 2021-05)
    Type of Medium: Online Resource
    ISSN: 2363-8397 , 2363-8400
    URL: Article
    DOI: 10.1007/s40944-021-00510-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2823586-1
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