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  • 1
    Online Resource
    Online Resource
    Premier cas de Candida auris multirésistant déclaré au Canada
    Infectious Disease and Control Branch (IDPCB) - Public Health Agency of Canada ; 2017
    In:  Relevé des maladies transmissibles au Canada Vol. 43, No. 7/8 ( 2017-7-6), p. 168-172
    Details
    In: Relevé des maladies transmissibles au Canada, Infectious Disease and Control Branch (IDPCB) - Public Health Agency of Canada, Vol. 43, No. 7/8 ( 2017-7-6), p. 168-172
    Type of Medium: Online Resource
    ISSN: 1719-3109
    Uniform Title: First reported case of multidrug-resistant Candida auris in Canada
    URL: Article
    DOI: 10.14745/ccdr.v43i78a02f
    Language: Unknown
    Publisher: Infectious Disease and Control Branch (IDPCB) - Public Health Agency of Canada
    Publication Date: 2017
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Amino acid sequence of a platelet-binding human anti-DNA monoclonal autoantibody
    American Society of Hematology ; 1989
    In:  Blood Vol. 74, No. 1 ( 1989-07-01), p. 262-269
    Details
    In: Blood, American Society of Hematology, Vol. 74, No. 1 ( 1989-07-01), p. 262-269
    Abstract: The complete amino acid sequences of the variable regions of the heavy and light chains of a human IgM monoclonal platelet-binding autoantibody have been determined. This antibody, HF2–1/17, produced by a human x human hybridoma prepared from lymphocytes of a patient with systemic lupus erythematosus and thrombocytopenia, is polyreactive with single-stranded DNA, synthetic polynucleotides, sulfated carbohydrates, and acidic glycolipids isolated from platelet membranes. The heavy chain is of the VHIII subgroup, and the light chain is of the VKI subgroup. The heavy chain is the expression product of the VH26 germline gene. The light chain bears significant homology to other immunoglobulins of known primary structure, including WEA, GAL, HAU, HK101, and DEE. These results suggest that HF2–1/17 may be an autoantibody derived with little or no modification from germline genes. A model of the antibody combining site suggests that arginine 24 and arginine 30 in the light chain (CDR1) interact with a surface defined by phosphate or sulfate groups of the antigen.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V74.1.262.262
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 1989
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND-study)
    Springer Science and Business Media LLC ; 2009
    In:  BMC Surgery Vol. 9, No. 1 ( 2009-12)
    Details
    In: BMC Surgery, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2009-12)
    Abstract: Recent non-randomized studies suggest that extended endoscopic mucosal resection (EMR) is equally effective in removing large rectal adenomas as transanal endoscopic microsurgery (TEM). If equally effective, EMR might be a more cost-effective approach as this strategy does not require expensive equipment, general anesthesia and hospital admission. Furthermore, EMR appears to be associated with fewer complications. The aim of this study is to compare the cost-effectiveness and cost-utility of TEM and EMR for the resection of large rectal adenomas. Methods/design Multicenter randomized trial among 15 hospitals in the Netherlands. Patients with a rectal adenoma ≥ 3 cm, located between 1–15 cm ab ano, will be randomized to a TEM- or EMR-treatment strategy. For TEM, patients will be treated under general anesthesia, adenomas will be dissected en-bloc by a full-thickness excision, and patients will be admitted to the hospital. For EMR, no or conscious sedation is used, lesions will be resected through the submucosal plane in a piecemeal fashion, and patients will be discharged from the hospital. Residual adenoma that is visible during the first surveillance endoscopy at 3 months will be removed endoscopically in both treatment strategies and is considered as part of the primary treatment. Primary outcome measure is the proportion of patients with recurrence after 3 months. Secondary outcome measures are: 2) number of days not spent in hospital from initial treatment until 2 years afterwards; 3) major and minor morbidity; 4) disease specific and general quality of life; 5) anorectal function; 6) health care utilization and costs. A cost-effectiveness and cost-utility analysis of EMR against TEM for large rectal adenomas will be performed from a societal perspective with respectively the costs per recurrence free patient and the cost per quality adjusted life year as outcome measures. Based on comparable recurrence rates for TEM and EMR of 3.3% and considering an upper-limit of 10% for EMR to be non-inferior (beta-error 0.2 and one-sided alpha-error 0.05), 89 patients are needed per group. Discussion The TREND study is the first randomized trial evaluating whether TEM or EMR is more cost-effective for the treatment of large rectal adenomas. Trial registration number (trialregister.nl) NTR1422
    Type of Medium: Online Resource
    ISSN: 1471-2482
    URL: Article
    DOI: 10.1186/1471-2482-9-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2009
    detail.hit.zdb_id: 2050442-1
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  • 4
    Online Resource
    Online Resource
    Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes
    Bioscientifica ; 2022
    In:  Yearbook of Paediatric Endocrinology ( 2022-09-12)
    Details
    In: Yearbook of Paediatric Endocrinology, Bioscientifica, ( 2022-09-12)
    Type of Medium: Online Resource
    ISSN: 1662-4009
    URL: Article
    DOI: 10.1530/ey.19.10.15
    Language: Unknown
    Publisher: Bioscientifica
    Publication Date: 2022
    detail.hit.zdb_id: 2580188-0
    Location Call Number Limitation Availability
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  • 5
    Online Resource
    Online Resource
    First reported case of multidrug-resistant Candida auris in Canada
    Infectious Disease and Control Branch (IDPCB) - Public Health Agency of Canada ; 2017
    In:  Canada Communicable Disease Report Vol. 43, No. 7-8 ( 2017-07-06), p. 150-153
    Details
    In: Canada Communicable Disease Report, Infectious Disease and Control Branch (IDPCB) - Public Health Agency of Canada, Vol. 43, No. 7-8 ( 2017-07-06), p. 150-153
    Type of Medium: Online Resource
    ISSN: 1481-8531
    URL: Article
    DOI: 10.14745/ccdr.v43i78a02
    Language: English
    Publisher: Infectious Disease and Control Branch (IDPCB) - Public Health Agency of Canada
    Publication Date: 2017
    detail.hit.zdb_id: 2016939-5
    Location Call Number Limitation Availability
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    Online Resource
  • 6
    Online Resource
    Online Resource
    Amino acid sequence of a platelet-binding human anti-DNA monoclonal autoantibody
    American Society of Hematology ; 1989
    In:  Blood Vol. 74, No. 1 ( 1989-07-01), p. 262-269
    Details
    In: Blood, American Society of Hematology, Vol. 74, No. 1 ( 1989-07-01), p. 262-269
    Abstract: The complete amino acid sequences of the variable regions of the heavy and light chains of a human IgM monoclonal platelet-binding autoantibody have been determined. This antibody, HF2–1/17, produced by a human x human hybridoma prepared from lymphocytes of a patient with systemic lupus erythematosus and thrombocytopenia, is polyreactive with single-stranded DNA, synthetic polynucleotides, sulfated carbohydrates, and acidic glycolipids isolated from platelet membranes. The heavy chain is of the VHIII subgroup, and the light chain is of the VKI subgroup. The heavy chain is the expression product of the VH26 germline gene. The light chain bears significant homology to other immunoglobulins of known primary structure, including WEA, GAL, HAU, HK101, and DEE. These results suggest that HF2–1/17 may be an autoantibody derived with little or no modification from germline genes. A model of the antibody combining site suggests that arginine 24 and arginine 30 in the light chain (CDR1) interact with a surface defined by phosphate or sulfate groups of the antigen.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V74.1.262.bloodjournal741262
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 1989
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
    Location Call Number Limitation Availability
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    Online Resource
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