In:
Liebigs Annalen, Wiley, Vol. 1997, No. 2 ( 1997-02), p. 413-417
Abstract:
The new amphiphilic dinucleoside phosphate, 2′‐deoxy‐5‐fluorouridylyl‐(3′→5′)‐2′‐deoxy‐5‐fluoro‐ N 4 ‐octadecylcytidine ( 4 ) was synthesized on a gram scale, using the phosphotriester method, starting from the cytostatic drug 2′‐deoxy‐5‐fluorouridine (5FdU) and 2′‐deoxy‐5‐fluoro‐ N 4 ‐octadecylcytidine ( 1d ). In in vitro clonogenic growth assays using the human pancreatic adenocarcinoma cell line MIA PaCa 2, the amphiphilic dimer was significantly more effective than the parent monomeric 5FdU. The IC 50 of the dimer was 10 μg/ml when applied as an aqueous solution and 12 μg/ml when given as a liposome dispersion, whereas with 5FdU the IC 50 concentration was not reached within the concentration range used.
Type of Medium:
Online Resource
ISSN:
0947-3440
DOI:
10.1002/jlac.v1997:2
DOI:
10.1002/jlac.199719970220
Language:
English
Publisher:
Wiley
Publication Date:
1997
detail.hit.zdb_id:
1475010-7
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