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  • 1
    Online Resource
    Online Resource
    Congenital Gingival Granular Cell Tumor. A Case Report.
    Nihon University School of Dentistry ; 1993
    In:  The Journal of Nihon University School of Dentistry Vol. 35, No. 2 ( 1993), p. 130-133
    Details
    In: The Journal of Nihon University School of Dentistry, Nihon University School of Dentistry, Vol. 35, No. 2 ( 1993), p. 130-133
    Type of Medium: Online Resource
    ISSN: 1884-2984 , 0029-0432
    URL: Article
    DOI: 10.2334/josnusd1959.35.130
    Language: English
    Publisher: Nihon University School of Dentistry
    Publication Date: 1993
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  • 2
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    A Histopathologic Investigation on the Effects of Electrical Stimulation on Periodontal Tissue Regeneration in Experimental Bony Defects in Dogs
    Wiley ; 2005
    In:  Journal of Periodontology Vol. 76, No. 12 ( 2005-12), p. 2194-2204
    Details
    In: Journal of Periodontology, Wiley, Vol. 76, No. 12 ( 2005-12), p. 2194-2204
    Abstract: Background: One endpoint of periodontal therapy is to regenerate the structure lost due to periodontal disease. In the periodontium, gingival epithelium is regenerated by oral epithelium. Underlying connective tissue, periodontal ligament, bone, and cementum are derived from connective tissue. Primitive connective tissue cells may develop into osteoblasts and cementoblasts, which form bone and cementum. Several procedural advances may support these regenerations; however, the regeneration of alveolar bone does not always occur. Therefore, bone stimulating factors are a main topic for periodontal reconstructive research. The present study was designed to examine histopathologically whether the application of an electrical field could demonstrate enhanced alveolar and cementum regeneration and modify tissue factors. Methods: Seven beagle dogs were used for this experiment. Mandibular left and right sides served as control and experimental sides, respectively, and 4‐walled intrabony defects were created bilaterally between the third and fourth premolars. The experimental side was treated with a capacitively coupled electrical field (CCEF) (sinusoidal wave, 60 kHz, and 5 V peak‐to‐peak), applied for 14 hours per day. The following measurements were performed on the microphotographs: 1) the distance from the cemento‐enamel junction to the apical notch (CEJ‐AN) and from the crest of newly formed bone (alveolar ridge) to the apical notch (AR‐AN); 2) the thickness of new cementum in the apical notch region; and 3) the length of junctional epithelium. The following histopathologic parameters were assessed by a semiquantitative subjective method: 1) inflammatory cell infiltration (ICI); 2) cellular activity of the periodontal ligament; 3) number and morphology of osteoclasts; 4) resorption lacunae; and 5) osteoblastic activity. Results: The results showed that the quantity of new bone fill and the mean value of the thickness of the cementum were significantly higher for the experimental side ( P 〈 0.01). The location of the base of the pocket was positioned more coronally with respect to the apical point of the coronal notch in the experimental side (statistically significant P 〈 0.01). The length of the junctional epithelium and the number of osteoclasts were higher in the stimulated side than the coronal side; these findings were also statistically significant ( P 〈 0.01). The comparison of the electrically stimulated versus non‐stimulated mandibles with the semiquantitative subjective method demonstrated statistically significant differences in defined histopathologic parameters, except for osteoclast morphologies ( P 〉 0.05). Conclusions: This study demonstrated that the CCEF method has the potential to produce reconstructive effects and bone deposits. Further investigations with respect to the theoretical determination of local field parameters of the periodontal tissue complex, such as permittivity, conductivity, strength of the field electrical stimulation applied to the periodontal field current density, wavelength, and signal frequency appropriate for this field, should be undertaken. Using different electromotive forces alone or in combination with bone graft materials, guided tissue regeneration techniques, and dental implants may achieve a new dimension in periodontal therapy in the near future.
    Type of Medium: Online Resource
    ISSN: 0022-3492 , 1943-3670
    URL: Article
    DOI: 10.1902/jop.2005.76.12.2194
    Language: English
    Publisher: Wiley
    Publication Date: 2005
    detail.hit.zdb_id: 2040047-0
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  • 3
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    Online Resource
    Expression of tight junction proteins in smokers and non‐smokers with generalized Stage III periodontitis
    Wiley ; 2023
    In:  Journal of Periodontal Research Vol. 58, No. 6 ( 2023-12), p. 1281-1289
    Details
    In: Journal of Periodontal Research, Wiley, Vol. 58, No. 6 ( 2023-12), p. 1281-1289
    Abstract: This study aims to evaluate the gingival crevicular fluid (GCF) levels of tumor necrosis factor‐α (TNF‐α), zonula occludens‐1 (ZO‐1), occludin (Occ), and tricellulin (Tric) in periodontitis, as well as their alterations due to smoking. Background Tight junctions (TJ), which consist of transmembrane and cytoplasmic scaffolding proteins, connect the epithelial cells of the periodontium. Occ, claudins, junctional adhesion molecules, and Tric are transmembrane TJ proteins found at the cell membrane. The transmembrane TJ proteins and the intracellular cytoskeleton are directly linked by cytoplasmic scaffolding proteins such as ZO‐1. Although the functions and locations of these molecules have been defined, their behavior in periodontal inflammation is unknown. Methods The study included four groups: individuals with periodontal health without smoking (C; n = 31), individuals with generalized Stage III periodontitis without smoking (P; n = 28), individuals with periodontal health while smoking (CS; n = 22), and individuals with generalized Stage III periodontitis while smoking (PS; n = 18). Clinical periodontal parameters were recorded, and enzyme‐linked immunosorbent assay (ELISA) was used to examine ZO‐1, Occ, Tric, and TNF‐α levels in GCF. Results In the periodontitis groups, clinical parameters were significantly higher ( p 〈 .001). The site‐specific levels of TNF‐α, ZO‐1, Tric, and Occ in the P group were statistically higher than those in the other groups ( p 〈 .05). TNF‐α, probing pocket depth (PPD), and bleeding on probing (BOP) exhibited positive correlations with all TJ proteins ( p 〈 .005). Conclusions Smoking could potentially affect the levels of epithelial TJ proteins in the GCF, thereby potentially playing a significant role in the pathogenesis of the periodontal disease.
    Type of Medium: Online Resource
    ISSN: 0022-3484 , 1600-0765
    URL: Issue
    URL: Article
    DOI: 10.1111/jre.v58.6
    DOI: 10.1111/jre.13184
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2025633-4
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  • 4
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    Online Resource
    Estrogen and progesterone receptors in the peripheral giant cell granulomas of the oral cavity.
    Nihon University School of Dentistry ; 1998
    In:  Journal of Oral Science Vol. 40, No. 2 ( 1998), p. 57-60
    Details
    In: Journal of Oral Science, Nihon University School of Dentistry, Vol. 40, No. 2 ( 1998), p. 57-60
    Type of Medium: Online Resource
    ISSN: 1880-4926 , 1343-4934
    URL: Article
    DOI: 10.2334/josnusd.40.57
    Language: English
    Publisher: Nihon University School of Dentistry
    Publication Date: 1998
    detail.hit.zdb_id: 2197202-3
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  • 5
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    Online Resource
    PERIODONTAL DOKULARI ETKILEYEN REAKTIF HIPERPLASTIK LEZYONLAR: 268 VAKADA GERÇEKLEŞTIRILEN RETROSPEKTIF BIR ÇALIŞMA
    The Journal of Faculty of Dentistry of Ataturk University ; 2022
    In:  Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi
    Details
    In: Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, The Journal of Faculty of Dentistry of Ataturk University
    Type of Medium: Online Resource
    ISSN: 1300-9044
    URL: Article
    DOI: 10.17567/ataunidfd.895815
    Language: Turkish
    Publisher: The Journal of Faculty of Dentistry of Ataturk University
    Publication Date: 2022
    detail.hit.zdb_id: 3142905-1
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  • 6
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    Generalized Aggressive Periodontitis in a Patient With Nephrotic Syndrome Associated With Primary Renal Amyloidosis: A Case Report
    Wiley ; 2014
    In:  Clinical Advances in Periodontics Vol. 4, No. 4 ( 2014-11), p. 226-233
    Details
    In: Clinical Advances in Periodontics, Wiley, Vol. 4, No. 4 ( 2014-11), p. 226-233
    Abstract: Introduction: Renal amyloidosis may lead to renal disease, and then nephrotic syndrome may develop. To the best of the authors’ knowledge, this is the first case report in which a patient presents with generalized aggressive periodontitis (GAgP) and nephrotic syndrome in conjunction with renal amyloidosis. Case Presentation: An 18‐year‐old male presented to the periodontology department for generalized gingival recessions. He was diagnosed as having primary renal amyloidosis by his physician. The patient presented with severe gingival inflammation and alveolar bone loss. Biochemical tests were within normal limits except for serum albumin level. No amyloid deposition was found in a gingival biopsy, and the patient was diagnosed as having GAgP. Non‐surgical periodontal treatment, in combination with antibiotic treatment, was performed. After 3 years, his systemic and periodontal conditions showed deterioration. Conclusions: The effects of systemic factors related to nephrotic syndrome in conjunction with renal amyloidosis and deterioration in oral hygiene may play a significant role in the progression of periodontal disease. Even if there is no amyloid deposition in periodontal tissues, clinicians should consider that nephrotic syndrome associated with systemic amyloidosis may provide an important contribution to the periodontal breakdown by the modifying conditions that affect the host response to the accumulation of dental biofilm.
    Type of Medium: Online Resource
    ISSN: 2573-8046 , 2163-0097
    URL: Article
    DOI: 10.1902/cap.2013.110086
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2670204-6
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  • 7
    Online Resource
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    Gingival Langerhans' Cells in Type I Diabetes Mellitus
    Wiley ; 1996
    In:  Journal of Periodontology Vol. 67, No. 1 ( 1996-01), p. 37-40
    Details
    In: Journal of Periodontology, Wiley, Vol. 67, No. 1 ( 1996-01), p. 37-40
    Abstract: Langerhans' cells (LC s ) are intraepithelial immunocompetent cells. Changes in the number of LCs occur in inflammatory and autoimmune diseases. In this study, the number of gingival LCs in patients with type I diabetes mellitus was compared with those of normal individuals using immunohistochemical methods. Gingival biopsies were obtained from 20 type I diabetics and 10 healthy individuals. Anti‐CD1 positive LCs formed an intraepithelial network and showed a marked increase in type I diabetics. This increase was not related to diabetic age. The number of LCs was proportional to the density of subepithelial inflammatory cells. Our findings suggest that LCs may play a role in the development of diabetic gingivitis. J Periodontol 1996;67:37–40 .
    Type of Medium: Online Resource
    ISSN: 0022-3492 , 1943-3670
    URL: Article
    DOI: 10.1902/jop.1996.67.1.37
    Language: English
    Publisher: Wiley
    Publication Date: 1996
    detail.hit.zdb_id: 2040047-0
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  • 8
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    Online Resource
    Destructive Membranous Periodontal Disease (Ligneous Periodontitis)
    Wiley ; 1999
    In:  Journal of Periodontology Vol. 70, No. 8 ( 1999-08), p. 919-925
    Details
    In: Journal of Periodontology, Wiley, Vol. 70, No. 8 ( 1999-08), p. 919-925
    Abstract: Generalized membranous gingival enlargement due to accumulation of amyloid or fibrin‐like material is a rare, destructive and poorly defined disease entity. Some patients also show extraoral manifestations. The lesion is an involvement of periodontal tissues caused by the same process as ligneous conjunctivitis. In this report, 3 new cases, two of whom are siblings, are presented. Defective fibrinolysis and abnormal wound healing seem to be the main pathogenetic mechanism of this unusual disease, which should be evaluated systemically considering other mucosal involvement. J Periodontol 1999;70:919‐925.
    Type of Medium: Online Resource
    ISSN: 0022-3492 , 1943-3670
    URL: Article
    DOI: 10.1902/jop.1999.70.8.919
    Language: English
    Publisher: Wiley
    Publication Date: 1999
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  • 9
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    Online Resource
    A Histopathological Investigation on the Effects of the Bisphosphonate Alendronate on Resorptive Phase Following Mucoperiosteal Flap Surgery in the Mandible of Rats
    Wiley ; 2000
    In:  Journal of Periodontology Vol. 71, No. 5 ( 2000-05), p. 790-796
    Details
    In: Journal of Periodontology, Wiley, Vol. 71, No. 5 ( 2000-05), p. 790-796
    Abstract: Background: The present study was designed to examine histopathologically whether local delivery of aminobisphosphonate (alendronate) could be effective in preventing the alveolar bone resorption associated with mucoperiosteal flaps. Methods: Following mucoperiosteal flap elevation in the molar region of the rat mandible, a surgical pellet soaked with aminobisphosphonate was locally applied on the exposed bone surface and covered by flap. The determined parameters with a semi‐quantitative subjective method for the histopathological evaluation were as follows: existing inflammatory cell infiltration of the related periodontal tissue; fibrotic component content and bundles of collagen fibers; the number and morphology of osteoclasts of the alveolar bone and interdental septum; existing resorption lacunae (osteoclast surfaces); and existing osteoblastic activity (forming surfaces). Results: The results showed that while there were no detectable statistically significant differences between the saline and alendronate‐treated groups on the existing inflammatory cell infiltration (ICI), number of osteoclasts, and osteoblastic activity, the results for the fibrotic and collagen component, osteoclast morphologies, and existing resorption lacunae were statistically significant. Conclusions: These results suggest that local application of the aminobisphosphonate alendronate can be used as an adjunct in therapy for reducing bone resorption following surgery. It can also be suggested for consideration that, even for the surgical approaches in dentistry where bone graft materials and/or dental implants are needed, using bisphosphonate may achieve a new dimension in periodontal therapy in the near future. J Periodontol 2000; 71:790‐796.
    Type of Medium: Online Resource
    ISSN: 0022-3492 , 1943-3670
    URL: Article
    DOI: 10.1902/jop.2000.71.5.790
    Language: English
    Publisher: Wiley
    Publication Date: 2000
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  • 10
    Online Resource
    Online Resource
    Examination of periodontal tissues by a cutting-grinding technique
    Wiley ; 1996
    In:  Australian Dental Journal Vol. 41, No. 3 ( 1996-06), p. 173-175
    Details
    In: Australian Dental Journal, Wiley, Vol. 41, No. 3 ( 1996-06), p. 173-175
    Type of Medium: Online Resource
    ISSN: 0045-0421 , 1834-7819
    URL: Issue
    URL: Article
    DOI: 10.1111/adj.1996.41.issue-3
    DOI: 10.1111/j.1834-7819.1996.tb04850.x
    Language: English
    Publisher: Wiley
    Publication Date: 1996
    detail.hit.zdb_id: 2059014-3
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