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  • 1
    In: Critical Care Nurse, AACN Publishing, Vol. 43, No. 1 ( 2023-02-01), p. 31-41
    Abstract: Awake prone positioning research focuses primarily on improving oxygenation and reducing intubation and mortality rates. Secondary outcomes concerning patient safety have been poorly addressed. Objective To summarize current evidence on the frequency of adverse events during awake prone positioning and the effects on patients’ safety, comfort, and tolerance. Methods This scoping review used the Preferred Reporting Items for Systematic Reviews and Meta-analyses Extension for Scoping Reviews. MEDLINE/PubMed and CINAHL databases were the primary sources for the systematic search. Results The review included 19 original studies involving 949 patients who underwent awake prone positioning. No major complications such as death, severe respiratory compromise, or hemodynamic disease were reported. Ten studies reported the following secondary adverse events related to awake prone positioning: skin breakdown (1%-6% of patients), pain (12%-42%), discomfort (35%-43%), vomiting (2%-7%), intolerance (3%-47%), and vascular catheter dislodgment (5%). The duration of awake prone positioning sessions varied widely (0.3-19 hours). Seven studies reported that nurses helped patients during prone positioning maneuvers, including monitoring and surveillance, and 3 studies reported patients placing themselves in the prone position. In 6 studies light or moderate sedation was employed in the procedures. Conclusions Awake prone positioning was not related to cardiorespiratory consequences but was associated with pain, intolerance, discomfort, and patients’ refusal. Patients should receive education regarding awake prone positioning to improve their acceptance. Health care professionals should optimize pain control, communication, patient comfort, patient adherence, and correct positioning.
    Type of Medium: Online Resource
    ISSN: 0279-5442 , 1940-8250
    Language: English
    Publisher: AACN Publishing
    Publication Date: 2023
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  • 2
    In: Intensive Care Medicine Experimental, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2023-06-30)
    Abstract: Endotracheal tube (ETT) clamping before disconnecting the patient from the mechanical ventilator is routinely performed in patients with acute respiratory distress syndrome (ARDS) to minimize alveolar de-recruitment. Clinical data on the effects of ETT clamping are lacking, and bench data are sparse. We aimed to evaluate the effects of three different types of clamps applied to ETTs of different sizes at different clamping moments during the respiratory cycle and in addition to assess pressure behavior following reconnection to the ventilator after a clamping maneuver. Methods A mechanical ventilator was connected to an ASL 5000 lung simulator using an ARDS simulated condition. Airway pressures and lung volumes were measured at three time points (5 s, 15 s and 30 s) after disconnection from the ventilator with different clamps (Klemmer, Chest-Tube and ECMO) on different ETT sizes (internal diameter of 6, 7 and 8 mm) at different clamping moments (end-expiration, end-inspiration and end-inspiration with tidal volume halved). In addition, we recorded airway pressures after reconnection to the ventilator. Pressures and volumes were compared among different clamps, different ETT-sizes and the different moments of clamp during the respiratory cycle. Results The efficacy of clamping depended on the type of clamp, the duration of clamping, the size of the ETT and the clamping moment. With an ETT ID 6 mm all clamps showed similar pressure and volume results. With an ETT ID 7 and 8 mm only the ECMO clamp was effective in maintaining stable pressure and volume in the respiratory system during disconnection at all observation times. Clamping with Klemmer and Chest-Tube at end inspiration and at end inspiration with halved tidal volume was more efficient than clamping at end expiration ( p   〈  0.03). After reconnection to the mechanical ventilator, end-inspiratory clamping generated higher alveolar pressures as compared with end-inspiratory clamping with halved tidal volume ( p   〈  0.001). Conclusions ECMO was the most effective in preventing significant airway pressure and volume loss independently from tube size and clamp duration. Our findings support the use of ECMO clamp and clamping at end-expiration. ETT clamping at end-inspiration with tidal volume halved could minimize the risk of generating high alveolar pressures following reconnection to the ventilator and loss of airway pressure under PEEP.
    Type of Medium: Online Resource
    ISSN: 2197-425X
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2740385-3
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  • 3
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 119, No. 31 ( 2022-08-02)
    Abstract: Root angle in crops represents a key trait for efficient capture of soil resources. Root angle is determined by competing gravitropic versus antigravitropic offset (AGO) mechanisms. Here we report a root angle regulatory gene termed ENHANCED GRAVITROPISM1 ( EGT1 ) that encodes a putative AGO component, whose loss-of-function enhances root gravitropism. Mutations in barley and wheat EGT1 genes confer a striking root phenotype, where every root class adopts a steeper growth angle. EGT1 encodes an F-box and Tubby domain-containing protein that is highly conserved across plant species. Haplotype analysis found that natural allelic variation at the barley EGT1 locus impacts root angle. Gravitropic assays indicated that Hvegt1 roots bend more rapidly than wild-type. Transcript profiling revealed Hvegt1 roots deregulate reactive oxygen species (ROS) homeostasis and cell wall-loosening enzymes and cofactors. ROS imaging shows that Hvegt1 root basal meristem and elongation zone tissues have reduced levels. Atomic force microscopy measurements detected elongating Hvegt1 root cortical cell walls are significantly less stiff than wild-type. In situ analysis identified HvEGT1 is expressed in elongating cortical and stele tissues, which are distinct from known root gravitropic perception and response tissues in the columella and epidermis, respectively. We propose that EGT1 controls root angle by regulating cell wall stiffness in elongating root cortical tissue, counteracting the gravitropic machinery’s known ability to bend the root via its outermost tissues. We conclude that root angle is controlled by EGT1 in cereal crops employing an antigravitropic mechanism.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    RVK:
    RVK:
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2022
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Firenze University Press ; 2022
    In:  infermieristica journal Vol. 1, No. 2 ( 2022-12-15), p. 61-66
    In: infermieristica journal, Firenze University Press, Vol. 1, No. 2 ( 2022-12-15), p. 61-66
    Abstract: The “weaning” from mechanical ventilation is a process that involves several assessments and steps to aid a patient to reach a “liberation” from the ventilator and allow for breathing autonomy.The process of “weaning” from mechanical ventilation involves several assessments and steps to support a patient in reaching a “liberation” from the ventilator and allow for spontaneous breathing. The weaning process consists of evaluating if the patient is able to breathe with minimal or no ventilation support. This assessment is performed by a diagnostic test named spontaneous breathing trial (SBT), repeated every 24 hours to ensure extubation success. Even though many patients do not meet the eligibility criteria for starting the weaning process, they can still be weaned. For this reason, these criteria should be evaluated in order to assess a possible weaning, rather than adopting absolute standards which have to be met simultaneously. The SBT helps the healthcare professionals to understand the patient’s capacity to sustain physiological breathing once they are extubated (or on spontaneous breathing if a tracheostomy tube is maintained in place). Several patients fail to meet the weaning criteria after less than 20 minutes of the SBT. Therefore, a 30-minute trial is enough to estimate the patient’s capacity to withhold spontaneous breathing. Even if the SBT is currently the gold standard method to conduct the weaning trial, it does not prevent the occurrence of complications after extubation such as upper airways obstruction, increased resistance, loss of airway protective reflexes, cough efficiency, and drainage of tracheobronchial secretions. The preventive use of NIV or High Flow Nasal Cannula is strongly recommended for patients experiencing extubation failure and mechanically ventilated for more than 24 hours after an SBT. A well-performed SBT usually leads to definitive extubation; on the other hand, SBT failure requires a comprehensive investigation on potentially reversible conditions. Prolonged weaning is highly wasteful in terms of time and resources due to the need for a systematic and multidisciplinary approach to successfully face the weaning process.
    Type of Medium: Online Resource
    ISSN: 2785-7018 , 2785-7034
    Language: Unknown
    Publisher: Firenze University Press
    Publication Date: 2022
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  • 5
    In: Scenario® - Il Nursing nella sopravvivenza, PAGEPress Publications, Vol. 37, No. 3 ( 2020-10-22), p. 24-28
    Abstract: Il concetto di terapia intensiva aperta prevede l’abbattimento delle barriere fisiche, comunicative e temporali rispetto al precedente modello di cura in area critica. A questi tre principi si stanno affiancando nuove sfide: la partecipazione dei familiari alle attività di nursing e al round di visita medica sul paziente. Al momento, però, rimangono aperte alcune importanti questioni, la mancata risposta alle domande che si pongono ancora oggi dietro il falso mito che vede il familiare come attore di interferenze con le cure e l’assistenza al paziente, e come portatore di infezioni alla persona oggetto delle visite. L’obiettivo del presente articolo è rilevare la presenza di evidenze scientifiche alla base delle attuali raccomandazioni sulle pratiche di vestizione dei visitatori in terapia intensiva.
    Type of Medium: Online Resource
    ISSN: 2239-6403 , 1592-5951
    Language: Unknown
    Publisher: PAGEPress Publications
    Publication Date: 2020
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  • 6
    In: Scenario® - Il Nursing nella sopravvivenza, PAGEPress Publications, Vol. 37, No. 1 ( 2020-04-09), p. 18-22
    Abstract: Introduzione: L’igiene del cavo orale rappresenta uno dei pilastri all’interno dei “fundamental of careâ€, trovando nel paziente critico con device endotracheale, in particolar modo quello ricoverato in terapia intensiva, una particolare ragion d’essere non soltanto nel mantenimento del comfort, ma anche e soprattutto nella prevenzione delle polmoniti associate a ventilazione meccanica (VAP). La clorexidina (CHX) collutorio o gel, usata in ambito odontoiatrico con ottimi risultati sull’abbattimento della placca batterica dentale, è diventata oggetto di attenzioni della ricerca clinica.
    Type of Medium: Online Resource
    ISSN: 2239-6403 , 1592-5951
    Language: Unknown
    Publisher: PAGEPress Publications
    Publication Date: 2020
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  • 7
    In: Scenario® - Il Nursing nella sopravvivenza, PAGEPress Publications, Vol. 37, No. 2 ( 2020-07-18), p. 16-30
    Abstract: Il weaning è un processo decisionale dinamico e collaborativo che copre l’intero processo di liberazione del paziente dal supporto ventilatorio meccanico e dal device endotracheale. I parametri clinici, strumentali e gli indici sono elementi che permettono di valutare la capacità di far fronte del paziente allo svezzamento dalla ventilazione meccanica e dunque il successo o il fallimento del processo stesso. L’obiettivo della presente revisione di letteratura è quello di rilevare il grado di efficacia di questi parametri e degli indici attualmente disponibili in termini di funzionalità predittive, e quindi di utilità nella pratica clinica.
    Type of Medium: Online Resource
    ISSN: 2239-6403 , 1592-5951
    Language: Unknown
    Publisher: PAGEPress Publications
    Publication Date: 2020
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  • 8
    Online Resource
    Online Resource
    PAGEPress Publications ; 2018
    In:  Scenario® - Il Nursing nella sopravvivenza Vol. 31, No. 4 ( 2018-01-19), p. 26-30
    In: Scenario® - Il Nursing nella sopravvivenza, PAGEPress Publications, Vol. 31, No. 4 ( 2018-01-19), p. 26-30
    Abstract: Introduzione: durante la ventilazione meccanica l’interazione tra paziente e macchina è caratterizzata da un delicato equilibrio, spesso alterato da molteplici fattori capaci di generare asincronie. L’infermiere ha la possibilità e il dovere di riconoscere e segnalare tempestivamente le alterazioni del monitoraggio grafico.
    Type of Medium: Online Resource
    ISSN: 2239-6403 , 1592-5951
    Language: Unknown
    Publisher: PAGEPress Publications
    Publication Date: 2018
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