In:
Neuroendocrinology, S. Karger AG, Vol. 101, No. 4 ( 2015), p. 321-330
Abstract:
〈 b 〉 〈 i 〉 Aims: 〈 /i 〉 〈 /b 〉 The aim of this study was to assess the usefulness of somatostatin receptor scintigraphy (SRS) using 〈 sup 〉 99m 〈 /sup 〉 Tc-[HYNIC, Tyr3]-octreotide (TOC) and 〈 sup 〉 123 〈 /sup 〉 I-metaiodobenzylguanidine (mIBG) in patients with 〈 i 〉 SDHx 〈 /i 〉 -related syndromes in which paragangliomas were detected by computed tomography and to establish an optimal imaging diagnostic algorithm in 〈 i 〉 SDHx 〈 /i 〉 mutation carriers. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 All carriers with clinical and radiological findings suggesting paragangliomas were screened by SRS and 〈 sup 〉 123 〈 /sup 〉 I-mIBG. Lesions were classified by body regions, i.e. head and neck, chest, abdomen with pelvis and adrenal gland as well as metastasis. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 We evaluated 46 〈 i 〉 SDHx 〈 /i 〉 gene mutation carriers (32 index cases and 14 relatives; 28 〈 i 〉 SDHD 〈 /i 〉 , 16 〈 i 〉 SDHB 〈 /i 〉 and 2 〈 i 〉 SDHC 〈 /i 〉 ). In this group, 102 benign tumors were found in 39 studied patients, and malignant disease was diagnosed in 7 patients. In benign tumors, the sensitivity of SRS was estimated at 77% and of 〈 sup 〉 123 〈 /sup 〉 I-mIBG at 22.0%. The SRS and mIBG sensitivity was found to be clearly region dependent (p 〈 0.001). The highest SRS sensitivity was found in head and neck paragangliomas (HNP; 91.4%) and the lowest was found in abdominal paragangliomas and pheochromocytomas (40 and 42.9%, respectively). The highest 〈 sup 〉 123 〈 /sup 〉 I-mIBG sensitivity was found in pheochromocytomas (sensitivity of 100%) and the lowest in HNP (sensitivity of 3.7%). In metastatic disease, SRS was superior to mIBG (sensitivity of 95.2 vs. 23.8%, respectively). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 SRS and 〈 sup 〉 123 〈 /sup 〉 I-mIBG single photon emission computed tomography (SPECT) sensitivity in 〈 i 〉 SDHx 〈 /i 〉 patients is highly body region dependent. In malignant tumors, SRS is superior to 〈 sup 〉 123 〈 /sup 〉 I-mIBG SPECT.
Type of Medium:
Online Resource
ISSN:
0028-3835
,
1423-0194
Language:
English
Publisher:
S. Karger AG
Publication Date:
2015
detail.hit.zdb_id:
1483028-0
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