In:
Science Signaling, American Association for the Advancement of Science (AAAS), Vol. 15, No. 724 ( 2022-03-08)
Abstract:
Patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) exhibit tissue edema, alveolar collapse, and respiratory failure. After sepsis, patients with ALI/ARDS exhibit immune cell infiltration in the lungs and excessive amounts of pro-inflammatory cytokines, and treatment options are limited. Noting that the protein Gas6, which is a ligand of the receptor tyrosine kinase Mer, is increased in abundance in the plasma of patients with septic ALI/ARDS, Fukatsu et al. examined the effects of the Mer inhibitor UNC2250 on disease in mice subjected to inhalation of LPS, a model of ALI. The authors found that blocking Gas6-Mer signaling resulted in less inflammation, immune cell infiltration, and lung damage in the lungs in mice, resulting in decreased mortality, as well as inhibiting immune cell proliferation in vitro. Together, these findings suggest that therapeutically targeting Mer may help to treat the inflammatory responses in ALI/ARDS.
Type of Medium:
Online Resource
ISSN:
1945-0877
,
1937-9145
DOI:
10.1126/scisignal.abd2533
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
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