In:
Clinical and Experimental Neuroimmunology, Wiley, Vol. 9, No. 3 ( 2018-08), p. 182-188
Abstract:
Systemic inflammation is known to be associated with Alzheimer's disease ( AD ) advancement. The aim of the present study was to examine the relationships of cognitive function in AD patients with the presence of systemic inflammation and immunological alterations. Methods Eight patients with AD and nine elderly individuals as a control group were enrolled, none of whom had a history of autoimmune diseases or were suffering from an infection. C‐reactive protein, interleukin‐6 and tumor necrosis factor‐α levels in serum were measured, while lymphocyte subsets were also determined using a flow cytometry system. In addition, two of the AD patients received repeated cognitive function and blood testing on an outpatient basis. Results In the AD group, the percentages of CD 3 − CD 16 + CD 56 + (natural killer) and CD 4 + CCR 5 + (type 1 helper T) cells, and CD 8 + CD 11a + (cytotoxic T) lymphocytes were increased, whereas the percentages of CD 19 + (B lymphocytes) and CD 4 + CD 25 bright CD 127 dim (regulatory T) cells were decreased as compared with the controls. Systemic inflammation, represented by elevated C‐reactive protein and interleukin‐6, was shown to aggravate cognitive function in both patients who underwent follow‐up outpatient examinations. However, lymphocyte subsets did not change in parallel with cognitive function. Conclusions Inflammatory acute clinical events have the potential to reduce cognitive function in AD patients, which could be partially attributed to a decrease in regulatory T cells in the blood. Furthermore, increased numbers of natural killer cells, cytotoxic T lymphocytes and type 1 helper T cells in these patients might reflect the presence of chronic inflammation, thus forming an immunological background.
Type of Medium:
Online Resource
ISSN:
1759-1961
,
1759-1961
DOI:
10.1111/cen3.2018.9.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2508135-4
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