In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 144, No. Suppl_1 ( 2021-11-16)
Abstract:
Introduction: Recent clinical practice guidelines emphasized the need to quantify patients’ symptoms, and health-related quality of life (HR-QoL) for patients with atrial fibrillation (AF). However, little is known about the associations between patients’ HR-QoL and subsequent clinical outcomes. Methods: We extracted data from a registry-based cohort study (KiCS-AF) designed to enroll consecutive AF patients referred to tertiary hospitals in Japan. Patients completed the Atrial Fibrillation Effects on QualiTy-of-Life (AFEQT) at referral. We investigated the association between the AFEQT-overall summary (AFEQT-OS; range 0-100, higher score indicates better HR-QoL) score and cumulative incidence of the composite of all-cause death, stroke, new-onset heart failure hospitalization, and acute coronary syndrome after 2 years of follow-up. Results: Among 3,313 AF patients (men 68.4%; age 67.8±11.6 years; 60.1% diagnosed ≤1 year before enrollment to the registry), 3,296 patients (99.4%) completed the AFEQT questionnaire at the time of registration. The mean AFEQT-OS score was 77.1±17.6, and 46.8% had AFEQT-OS 〈 80, which indicated impaired HR-QoL. Female sex, education level, higher heart rate, paroxysmal AF, history of congestive heart failure were independently associated with impaired HR-QoL at registration. After a 2-year follow-up (mean 675±143 days), the patients with impaired HR-QoL were more likely to experience the composite outcomes than those without (8.5% vs 5.8%, adjusted OR 1.32 [95%CI 1.01-1.74] P=0.040), and the differences were mainly driven by the incidence of new-onset heart failure hospitalization. Conclusion: In a Japanese, contemporary clinical practice cohort of unselected AF patients with newly diagnosis, almost half of the patients had impaired HR-QoL with worse clinical outcomes after 2-year. Factors associated with patients’ HR-QoL were multifocal and further investigations were needed to clarify the underlying mechanism.
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.144.suppl_1.9716
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2021
detail.hit.zdb_id:
1466401-X
Permalink