In:
Neuropsychobiology, S. Karger AG, Vol. 59, No. 3 ( 2009), p. 151-158
Abstract:
〈 i 〉 Background/Aims: 〈 /i 〉 An association between the 〈 i 〉 II 〈 /i 〉 genotype of the angiotensin-converting enzyme (ACE) insertion 〈 i 〉 (I) 〈 /i 〉 /deletion 〈 i 〉 (D) 〈 /i 〉 polymorphism and suicide was found among Japanese men. Our purpose was to replicate this finding in Caucasians and explore other putative genotypic associations among suicides. 〈 i 〉 Methods: 〈 /i 〉 The 〈 i 〉 ACE 〈 /i 〉 genotypes were studied by a 2-stage PCR method in 150 completed suicides and 165 age- and sex-matched controls. 〈 i 〉 Results: 〈 /i 〉 We found an increase in the frequency of the 〈 i 〉 ACE 〈 /i 〉 〈 i 〉 I 〈 /i 〉 allele among male victims of suicide compared to male controls (odds ratio, OR = 1.69, p 〈 0.006), female suicides (OR = 2.01, p = 0.006) and pooled controls (OR = 1.77, p = 0.001). Analysis of genotype distribution showed that the codominant model had the best fit (p = 0.7) whereas the recessive model could be rejected (p = 0.04). Among males we found an association between the number of the 〈 i 〉 ACE I 〈 /i 〉 allele and the method of suicide: OR = 17.98, p 〈 sub 〉 corrected 〈 /sub 〉 = 0.00003, for jumping from a height; OR = 0.36, p 〈 sub 〉 corrected 〈 /sub 〉 = 0.048, for hanging. We also observed a trend for a negative effect of the number of copies of the 〈 i 〉 ACE I 〈 /i 〉 allele on prevalence of depression (OR = 0.36, p = 0.013) and a trend for an effect on age at death (p = 0.021). 〈 i 〉 Conclusions: 〈 /i 〉 Our results suggest that low ACE activity associated with the 〈 i 〉 I 〈 /i 〉 allele is a risk factor for suicide, especially in a subset of males. This may be of concern given the widespread use of drugs lowering ACE activity.
Type of Medium:
Online Resource
ISSN:
0302-282X
,
1423-0224
Language:
English
Publisher:
S. Karger AG
Publication Date:
2009
detail.hit.zdb_id:
1483094-2
SSG:
5,2
SSG:
15,3
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