In:
Angewandte Chemie, Wiley, Vol. 127, No. 8 ( 2015-02-16), p. 2550-2554
Abstract:
The first asymmetric nickel‐catalyzed intramolecular reductive cyclization of alkynones is reported. A P‐chiral monophosphine and triethylsilane were used as the ligand and the reducing reagent, respectively, to form a series of tertiary allylic alcohols bearing furan/pyran rings in excellent yields and enantioselectivities. This reaction has a broad substrate scope and enabled the efficient synthesis of dehydroxycubebin and chiral dibenzocyclooctadiene skeletons.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.201410700
Language:
English
Publisher:
Wiley
Publication Date:
2015
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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