In:
Clinical and Experimental Immunology, Oxford University Press (OUP), Vol. 122, No. 2 ( 2008-10-09), p. 207-211
Abstract:
The role of interleukin (IL)-8 as mediator in the recruitment of leucocytes into the CSF was investigated during experimental pneumococcal meningitis. Rabbits were inoculated intracisternally with approximately 106 CFU Streptococcus pneumoniae, and treated (i) intravenously with 5 mg of a monoclonal antibody to IL-8 (n = 7) or 5 mg of an isotype control antibody (n = 6); (ii) intracisternally with anti-IL-8, 100 µg (n = 5), 10 µg (n = 4), 1 µg (n = 4), 0·1 µg (n = 2). Ten rabbits served as untreated control group. Intravenous treatment with anti-IL-8 attenuated the pleocytosis significantly compared to untreated rabbits (P & lt; 0·04) or rabbits treated with an isotype control antibody (P & lt; 0·02). In contrast, intracisternal treatment with anti-IL-8 failed to attenuate the pleocytosis (P & gt; 0·05). These results show, that IL-8 plays an important role in the recruitment of leucocytes during experimental pneumococcal meningitis, and that the functional activity of IL-8 in this process appears to be on the bloodstream side of the microvascular endothelium of the brain.
Type of Medium:
Online Resource
ISSN:
1365-2249
,
0009-9104
DOI:
10.1046/j.1365-2249.2000.01357.x
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2008
detail.hit.zdb_id:
2020024-9
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